Signature program: a platform of basket trials von Slosberg, Eric D, Kang, Barinder P, Peguero, Julio, Taylor, Matthew, Bauer, Todd M, Berry, Donald A, Braiteh, Fadi, Spira, Alexander, Meric-Bernstam, Funda, Stein, Steven, Piha-Paul, Sarina A, Salvado, August

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Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β1-dependent pathway von JIANG, Xiao-Hua, LAM, Shiu-Kum, LIN, Marie C. M, JIANG, Shi-Hu, KUNG, Hsiang-Fu, SLOSBERG, Eric D, JAE WON SOH, WEINSTEIN, I. Bernard, WONG, Benjamin Chun-Yu

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Treatment of Type 2 Diabetes by Adenoviral-Mediated Overexpression of the Glucokinase Regulatory Protein von SLOSBERG, Eric D, DESAI, Urvi J, FANELLI, Barbara, DENNY, Irene St, CONNELLY, Sheila, KALEKO, Michael, BOETTCHER, Brian R, CAPLAN, Shari L

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Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis von Quintavalla, Joseph, Kumar, Chandrika, Daouti, Sherif, Slosberg, Eric, Uziel-Fusi, Susan

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Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice von YAO YAO, SLOSBERG, E. D, LEI WANG, HIBSHOOSH, H, ZHANG, Y.-J, XING, W.-Q, SANTELLA, R. M, WEINSTEIN, I. B

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Phenotypic Correction of Diabetic Mice by Adenovirus-Mediated Glucokinase Expression von DESAI, Urvi J, SLOSBERG, Eric D, BOETTCHER, Brian R, CAPLAN, Shari L, FANELLI, Barbara, STEPHAN, Zouhair, GUNTHER, Vicky J, KALEKO, Michael, CONNELLY, Sheila

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Inhibition of EZH1 and EZH2 Restores Chemosensitivity of Leukemia Stem Cells in Acute Myeloid Leukemia By Recruitment of Quiescent AML Stem/Progenitor Cells von Chang, Kyung Hee, Alaniz, Zoe, Nishida, Yuki, Dos Santos, Cedric E., Slosberg, Eric, Daver, Naval, Andreeff, Michael

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Abstract 6320: CUSP06/AMT-707, a new CDH6-targeting antibody-drug conjugate, demonstrates potent antitumor activity in preclinical models von Lu, Wei, Shi, Jing, Liu, Shu-Hui, Covino, Nicole, Meng, Xun, Slosberg, Eric D.

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Abstract LB-264: Autophagy modulates intracellular dynamics of [fam-] trastuzumab deruxtecan (DS-8201a), a novel HER2 antibody-drug conjugate (HER2-ADC) von Abe, Manabu, Nagata, Motoko, Koyama, Kumiko, Yasuda, Satoru, Hirata, Tsuyoshi, Kuwahara, Yusuke, Inaki, Koichiro, Kasanuki, Naomi, Minami, Megumi, Hagihara, Katsunobu, Wakita, Kenichi, Slosberg, Eric, Murakami, Masato

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Abstract B22: Outcomes and genomic mutational profiling results in patients with cancers of the head and neck treated with dovitinib in the Signature Program von Piha-Paul, Sarina A., Knost, James A., Raez, Luis E., Cohn, Allen L., Tawbi, Hussein A., Parasuraman, Sudha, Kang, Barinder P., Matys, Renata M., Slosberg, Eric D.

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Abstract A53: Outcomes and genomic mutation profiling results in a subset of patients with gynecologic cancers treated with buparlisib in the Signature Program von Piha-Paul, Sarina A., Spitz, Daniel L., Beck, J. Thaddeus, Braiteh, Fadi S., Buscema, Joseph, Frank, Richard, Parasuraman, Sudha, Kang, Barinder P., Matys, Renata M., Slosberg, Eric D.

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Phase I study of INC280 plus erlotinib in patients with MET expressing adenocarcinoma of the lung von McCoach, Caroline Elizabeth, Yu, Aiming, Gandara, David R., Riess, Jonathan, Li, Tianhong, Lara, Primo, Mack, Philip C., Beckett, Laurel, Slosberg, Eric Daniel, Kelly, Karen

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Genomic mutation profiling (GMP) and clinical outcome in patients (pts) treated with ribociclib (CDK4/6 inhibitor) in the Signature program von Peguero, Julio Antonio, O'Neil, Bert H., Sohal, Davendra, Bauer, Todd Michael, Subbiah, Vivek, Kelly, Karen, Grilley-Olson, Juneko E., Nadauld, Lincoln, Safran, Howard, Slosberg, Eric Daniel, Sidhu, Rajinder, Stealey, Erica, Parasuraman, Sudha, Kang, Barinder, Eder, Joseph Paul

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Response of tumor-induced osteomalacia (TIO) to the FGFR inhibitor BGJ398 von Miller, Carole Brennan, Bergwitz, Clemens, Blau, Jenny, Boyce, Alison, Gafni, Rachel I, Guthrie, Lori, Papadakis, Georgios Z, Miranda, Flora, Slosberg, Eric Daniel, Graus-Porter, Diana, Hopmann, Christine, Glass, Erica, Isaacs, Randi, Collins, Michael T.

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Colorectal cancer (CRC) cohort analysis of patients treated with buparlisib in a distinctive tissue-agnostic trial model for molecularly preselected tumors von Piha-Paul, Sarina Anne, Knost, James A., Nikolinakos, Petros, Schwartzberg, Lee Steven, Yardley, Denise A., Slosberg, Eric Daniel, Kang, Barinder, White, Theresa, Lebedinsky, Claudia

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The Signature Program, a Distinctive Tissue Agnostic Trial Model for Molecularly Pre-Selected Hematological and Solid Tumor Patients von Giles, Frank, Piha-Paul, Sarina A., Spira, Alexander I., Braiteh, Fadi, Peguero, Julio Antonio, Spitz, Daniel L., Knost, James A., Schwartzberg, Lee, Stein, Steven, Salvado, August J., Lebedinsky, Claudia, Kang, Barinder, Slosberg, Eric

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The signature program, a series of tissue-agnostic, mutation-specific signal finding trials von Slosberg, Eric Daniel, Kang, Barinder, Beck, J. Thaddeus, Piha-Paul, Sarina Anne, Green, Robert J., Richards, Donald A., Corless, Christopher L., Berry, Donald A., Stein, Steven H., Salvado, August J.

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Successful implementation of a novel trial model: The Signature program von Peguero, Julio Antonio, Knost, James A., Bauer, Todd Michael, Taylor, Matthew Hiram, Braiteh, Fadi S., Eder, Joseph Paul, Safran, Howard, O'Neil, Bert H., Alva, Ajjai Shivaram, Nadauld, Lincoln, Joshi, Prashant, Miranda, Flora, Sidhu, Rajinder, Ero, Joy, Slosberg, Eric Daniel, Lebedinsky, Claudia, Kang, Barinder, Parasuraman, Sudha, Piha-Paul, Sarina Anne

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Overexpression of protein kinase C-β1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells von Zhu, Geng Hui, Wong, Benjamin Chun Yu, Slosberg ‡, Eric D., Eggo §, Margaret C., Ching, Chi Kong, Yuen ∥, Siu Tsan, Lai, Kam Chuen, Soh ‡, Jae Won, Weinstein ‡, I.Bernard, Lam, Shiu Kum

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Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-beta(1)-dependent pathway von Jiang, Xiao-Hua, Lam, Shiu-Kum, Lin, Marie C M, Jiang, Shi-Hu, Kung, Hsiang-Fu, Slosberg, Eric D, Soh, Jae Won, Weinstein, I Bernard, Wong, Benjamin Chun-Yu

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