Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options von Skowron, Margaretha A, Kotthoff, Mara, Bremmer, Felix, Ruhnke, Katja, Parmaksiz, Fatma, Richter, Annika, Küffer, Stefan, Reuter-Jessen, Kirsten, Pauls, Stella, Stefanski, Anja, Ströbel, Philipp, Stühler, Kai, Nettersheim, Daniel

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Prodigiosin Sensitizes Sensitive and Resistant Urothelial Carcinoma Cells to Cisplatin Treatment von Berning, Lena, Schlütermann, David, Friedrich, Annabelle, Berleth, Niklas, Sun, Yadong, Wu, Wenxian, Mendiburo, María José, Deitersen, Jana, Brass, Hannah U C, Skowron, Margaretha A, Hoffmann, Michèle J, Niegisch, Günter, Pietruszka, Jörg, Stork, Björn

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Molecular and epigenetic pathogenesis of germ cell tumors von Müller, Melanie R., Skowron, Margaretha A., Albers, Peter, Nettersheim, Daniel

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Profiling the 3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level von Skowron, Margaretha A., Eul, Katharina, Stephan, Alexa, Ludwig, Gillian F., Wakileh, Gamal A., Bister, Arthur, Söhngen, Christian, Raba, Katharina, Petzsch, Patrick, Poschmann, Gereon, Kuffour, Edmund Osei, Degrandi, Daniel, Ali, Shafaqat, Wiek, Constanze, Hanenberg, Helmut, Münk, Carsten, Stühler, Kai, Köhrer, Karl, Mass, Elvira, Nettersheim, Daniel

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The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas von Skowron, Margaretha A., Becker, Teresa K., Kurz, Lukas, Jostes, Sina, Bremmer, Felix, Fronhoffs, Florian, Funke, Kai, Wakileh, Gamal A., Müller, Melanie R., Burmeister, Aaron, Lenz, Thomas, Stefanski, Anja, Stühler, Kai, Petzsch, Patrick, Köhrer, Karl, Altevogt, Peter, Albers, Peter, Kristiansen, Glen, Schorle, Hubert, Nettersheim, Daniel

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ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 while ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibit... von Kurz, Lukas, Miklyaeva, Alissa, Skowron, Margaretha A, Overbeck, Nina, Poschmann, Gereon, Becker, Teresa, Eul, Katharina, Kurz, Thomas, Schönberger, Stefan, Calaminus, Gabriele, Stühler, Kai, Dykhuizen, Emily, Albers, Peter, Nettersheim, Daniel

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Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates von Wakileh, Gamal A., Bierholz, Philipp, Kotthoff, Mara, Skowron, Margaretha A., Bremmer, Felix, Stephan, Alexa, Anbuhl, Stephanie M., Heukers, Raimond, Smit, Martine J., Ströbel, Philipp, Nettersheim, Daniel

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Applying the chicken embryo chorioallantoic membrane assay to study treatment approaches in urothelial carcinoma von Skowron, Margaretha A., M.Sc, Sathe, Anuja, M.D., Ph.D, Romano, Andrea, Ph.D, Hoffmann, Michèle J., Ph.D, Schulz, Wolfgang A., Ph.D, van Koeveringe, Gommert A., M.D, Albers, Peter, M.D, Nawroth, Roman, Ph.D, Niegisch, Günter, M.D

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Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2 von Schmitt, Laura, Lechtenberg, Ilka, Drießen, Daniel, Flores-Romero, Hector, Skowron, Margaretha A., Sekeres, Marlena, Hoppe, Julia, Krings, Karina S., Llewellyn, Tanya R., Peter, Christoph, Stork, Björn, Qin, Nan, Bhatia, Sanil, Nettersheim, Daniel, Fritz, Gerhard, García-Sáez, Ana J., Müller, Thomas J. J., Wesselborg, Sebastian

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The New Immortalized Uroepithelial Cell Line HBLAK Contains Defined Genetic Aberrations Typical of Early Stage Urothelial Tumors von Hoffmann, Michèle J., Koutsogiannouli, Evangelia, Skowron, Margaretha A., Pinkerneil, Maria, Niegisch, Günter, Brandt, Artur, Stepanow, Stefanie, Rieder, Harald, Schulz, Wolfgang A.

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The developmental origin of cancers defines basic principles of cisplatin resistance von Skowron, Margaretha A., Oing, Christoph, Bremmer, Felix, Ströbel, Philipp, Murray, Matthew J., Coleman, Nicholas, Amatruda, James F., Honecker, Friedemann, Bokemeyer, Carsten, Albers, Peter, Nettersheim, Daniel

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Three-Dimensional Cultivation of Germ Cell Cancer Cell Lines as Hanging Drops von Skowron, Margaretha A., Watolla, Meike M., Nettersheim, Daniel

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CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms von Skowron, Margaretha A., Vermeulen, Marieke, Winkelhausen, Anna, Becker, Teresa K., Bremmer, Felix, Petzsch, Patrick, Schönberger, Stefan, Calaminus, Gabriele, Köhrer, Karl, Albers, Peter, Nettersheim, Daniel

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The pioneer and differentiation factor FOXA2 is a key driver of yolk‐sac tumour formation and a new biomarker for paediatric and adult yolk‐sac tumours von Wruck, Wasco, Bremmer, Felix, Kotthoff, Mara, Fichtner, Alexander, Skowron, Margaretha A., Schönberger, Stefan, Calaminus, Gabriele, Vokuhl, Christian, Pfister, David, Heidenreich, Axel, Albers, Peter, Adjaye, James, Nettersheim, Daniel

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CD24 targeting with NK-CAR immunotherapy in testis, prostate, renal and (luminal-type) bladder cancer and identification of direct CD24 interaction partners von Söhngen, Christian, Thomas, David J, Skowron, Margaretha A, Bremmer, Felix, Eckstein, Markus, Stefanski, Anja, Driessen, Marc D, Wakileh, Gamal A, Stühler, Kai, Altevogt, Peter, Theodorescu, Dan, Klapdor, Rüdiger, Schambach, Axel, Nettersheim, Daniel

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Assessing the risk to develop a growing teratoma syndrome based on molecular and epigenetic subtyping as well as novel secreted biomarkers von Pongratanakul, Pailin, Bremmer, Felix, Pauls, Stella, Poschmann, Gereon, Kresbach, Catena, Parmaksiz, Fatma, Skowron, Margaretha A., Fuß, Janina, Stephan, Alexa, Paffenholz, Pia, Stühler, Kai, Schüller, Ulrich, Ströbel, Philipp, Heidenreich, Axel, Che, Yue, Albers, Peter, Nettersheim, Daniel

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Characterization of the dehydrogenase-reductase DHRS2 and its involvement in histone deacetylase inhibition in urological malignancies von Müller, Melanie R., Burmeister, Aaron, Skowron, Margaretha A., Stephan, Alexa, Söhngen, Christian, Wollnitzke, Philipp, Petzsch, Patrick, Alves Avelar, Leandro A., Kurz, Thomas, Köhrer, Karl, Levkau, Bodo, Nettersheim, Daniel

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Establishment and Evaluation of Dual HDAC/BET Inhibitors as Therapeutic Options for Germ Cell Tumors and Other Urological Malignancies von Burmeister, Aaron, Stephan, Alexa, Alves Avelar, Leandro A, Müller, Melanie R, Seiwert, Andrea, Höfmann, Stefan, Fischer, Fabian, Torres-Gomez, Hector, Hoffmann, Michèle J, Niegisch, Guenter, Bremmer, Felix, Petzsch, Patrick, Köhrer, Karl, Albers, Peter, Kurz, Thomas, Skowron, Margaretha A, Nettersheim, Daniel

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Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophages von Stephan, Alexa, Suhrmann, Jan-Henrik, Skowron, Margaretha A., Che, Yue, Poschmann, Gereon, Petzsch, Patrick, Kresbach, Catena, Wruck, Wasco, Pongratanakul, Pailin, Adjaye, James, Stühler, Kai, Köhrer, Karl, Schüller, Ulrich, Nettersheim, Daniel

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Evaluation of Chemotherapeutic Drugs for Treatment of (Cisplatin-Resistant) Germ Cell Cancer Cell Lines von Skowron, Margaretha A., Hoffmann, Michèle J., Watolla, Meike M., Nettersheim, Daniel

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