The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America von Grimm, Scott W., Einolf, Heidi J., Hall, Steven D., He, Kan, Lim, Heng-Keang, Ling, Kah-Hiing John, Lu, Chuang, Nomeir, Amin A., Seibert, Eleanore, Skordos, Konstantine W., Tonn, George R., Van Horn, Robert, Wang, Regina W., Wong, Y. Nancy, Yang, Tian J., Obach, R. Scott

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Utilizing Drug-Drug Interaction Prediction Tools during Drug Development: Enhanced Decision Making Based on Clinical Risk von Shardlow, Carole E., Generaux, Grant T., MacLauchlin, Christopher C., Pons, Nicoletta, Skordos, Konstantine W., Bloomer, Jackie C.

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The metabolic drug-drug interaction profile of Dabrafenib: in vitro investigations and quantitative extrapolation of the P450-mediated DDI risk von Lawrence, Sarah K, Nguyen, Dung, Bowen, Chet, Richards-Peterson, Lauren, Skordos, Konstantine W

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Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain von Qian, Yongzhen, Hua, Emily, Bisht, Kheem, Woditschka, Stephan, Skordos, Konstantine W., Liewehr, David J., Steinberg, Seth M., Brogi, Edi, Akram, Muzaffar M., Killian, J. Keith, Edelman, Daniel C., Pineda, Marbin, Scurci, Stephanie, Degenhardt, Yan Y., Laquerre, Sylvie, Lampkin, Thomas A., Meltzer, Paul S., Camphausen, Kevin, Steeg, Patricia S., Palmieri, Diane

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Single Mutations Change CYP2F3 From a Dehydrogenase of 3-Methylindole to an Oxygenase von Kartha, Jaya S, Skordos, Konstantine W, Sun, Hao, Hall, Clifton, Easterwood, LaHoma M, Reilly, Christopher A, Johnson, Eric F, Yost, Garold S

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Identification of Phase I Metabolites of 3-Methylindole Produced by Pig Liver Microsomes von Diaz, Gonzalo J., Skordos, Konstantine W., Yost, Garold S., Squires, E. James

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Evidence Supporting the Formation of 2,3-Epoxy-3-methylindoline:  A Reactive Intermediate of the Pneumotoxin 3-Methylindole von Skordos, Konstantine W, Skiles, Gary L, Laycock, John D, Lanza, Diane L, Yost, Garold S

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Thioether Adducts of a New Imine Reactive Intermediate of the Pneumotoxin 3-Methylindole von Skordos, Konstantine W, Laycock, John D, Yost, Garold S

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Abstract 1752: A phase I/IIa, first time in human, open-label dose-escalation study of GSK2636771 in subjects with advanced solid tumors with PTEN deficiency von Blackman, Samuel C., Gainer, Shelby D., Suttle, Benjamin B., Skordos, Konstantine W., Greshock, Joel D., Motwani, Monica, Roadcap, Lori T., Hardwicke, Mary Ann A., Wooster, Richard F.

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3-Methylindole-Induced Toxicity to Human Bronchial Epithelial Cell Lines von Nichols, William K., Mehta, Rashmi, Skordos, Konstantine, Macé, Katherine, Pfeifer, Andrea M. A., Carr, Brian A., Minko, Tamara, Burchiel, Scott W., Yost, Garold S.

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