The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future von Mennen, Steven M, Alhambra, Carolina, Allen, C. Liana, Barberis, Mario, Berritt, Simon, Brandt, Thomas A, Campbell, Andrew D, Castañón, Jesús, Cherney, Alan H, Christensen, Melodie, Damon, David B, Eugenio de Diego, J, García-Cerrada, Susana, García-Losada, Pablo, Haro, Rubén, Janey, Jacob, Leitch, David C, Li, Ling, Liu, Fangfang, Lobben, Paul C, MacMillan, David W. C, Magano, Javier, McInturff, Emma, Monfette, Sebastien, Post, Ronald J, Schultz, Danielle, Sitter, Barbara J, Stevens, Jason M, Strambeanu, Iulia I, Twilton, Jack, Wang, Ke, Zajac, Matthew A

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Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib von Connor, Christina G, DeForest, Jacob C, Dietrich, Phil, Do, Nga M, Doyle, Kevin M, Eisenbeis, Shane, Greenberg, Elizabeth, Griffin, Sarah H, Jones, Brian P, Jones, Kris N, Karmilowicz, Michael, Kumar, Rajesh, Lewis, Chad A, McInturff, Emma L, McWilliams, J. Christopher, Mehta, Ruchi, Nguyen, Bao D, Rane, Anil M, Samas, Brian, Sitter, Barbara J, Ward, Howard W, Webster, Mark E

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Enabled Process To Synthesize Monobactam 1 for Early Development von Tao, Yong, Lall, Manjinder S, Boyles, David C, Lilley, Susan C, Pattavina, Sebastian D, Rafka, Robert J, Sitter, Barbara J, Stewart, Andrew Morgan, Szeliga, Jan, Weisenburger, Gerald A

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Construction of the (1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane Ring System von Braish, Tamim F., Castaldi, Michael, Chan, Samantha, Fox, Darrell E., Keltonic, Tom, McGarry, James, Hawkins, Joel M., Norris, Timothy, Rose, Peter R., Sieser, Janice E., Sitter, Barbara J., Watson, Harry

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A PRACTICAL SYNTHESIS OF 4-BROMO-2-CYANO-3-METHYL-2-BUTENENITRILE von Newton, Linda S., Chan, Samantha, Sitter, Barbara J., Brenek, Steven J., Raggon, Jeffery W., Braish, Tamim F.

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The German Chronic Kidney Disease (GCKD) study: design and methods von ECKARDT, Kai-Uwe, BÄRTHLEIN, Barbara, HILGE, Robert, HILGERS, Karl F, KIELSTEIN, Jan T, KRANE, Vera, KÖTTGEN, Anna, KRONENBERG, Florian, OEFNER, Peter, PROKOSCH, Hans-Ulrich, REIS, Andre, SCHMID, Matthias, BAID-AGRAWAL, Seema, SCHAEFFNER, Elke, SCHULTHEISS, Ulla T, SEUCHTER, Susanne A, SITTER, Thomas, SOMMERER, Claudia, WALZ, Gerd, WANNER, Christoph, WOLF, Gunter, ZEIER, Martin, TITZE, Stephanie, BECK, Andreas, BUSCH, Martin, EITNER, Frank, EKICI, Arif B, FLOEGE, Jürgen, GEFELLER, Olaf, HALLER, Hermann

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Disease burden and risk profile in referred patients with moderate chronic kidney disease: composition of the German Chronic Kidney Disease (GCKD) cohort von Titze, Stephanie, Schmid, Matthias, Köttgen, Anna, Busch, Martin, Floege, Jürgen, Wanner, Christoph, Kronenberg, Florian, Eckardt, Kai-Uwe

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Mitochondrial DNA copy number is associated with mortality and infections in a large cohort of patients with chronic kidney disease von Fazzini, Federica, Lamina, Claudia, Fendt, Liane, Schultheiss, Ulla T., Kotsis, Fruzsina, Hicks, Andrew A., Meiselbach, Heike, Weissensteiner, Hansi, Forer, Lukas, Krane, Vera, Eckardt, Kai-Uwe, Köttgen, Anna, Kronenberg, Florian, Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus, Dienemann, Thomas, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Ganslandt, Thomas, Reis, André, Ekici, Arif B., Avendaño, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Zitzmann, Rita, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla, Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Schlieper, Georg, Saritas, Turgay, Ernst, Sabine, Beaujean, Nicole, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Woitke, Rebecca, Wolf, Gunter, Busch, Martin, Fuß, Rainer, Sitter, Thomas, Blank, Claudia, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, Schmid, Matthias, Nadal, Jennifer

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Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study von Steinbrenner, Inga, Schultheiss, Ulla T., Kotsis, Fruzsina, Schlosser, Pascal, Stockmann, Helena, Mohney, Robert P., Schmid, Matthias, Oefner, Peter J., Eckardt, Kai-Uwe, Köttgen, Anna, Sekula, Peggy, Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer

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Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: the German Chronic Kidney Disease (GCKD) study von Jing, Jiaojiao, Kielstein, Jan T, Schultheiss, Ulla T, Sitter, Thomas, Titze, Stephanie I, Schaeffner, Elke S, McAdams-DeMarco, Mara, Kronenberg, Florian, Eckardt, Kai-Uwe, Köttgen, Anna

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Self-Reported Medication Use and Urinary Drug Metabolites in the German Chronic Kidney Disease (GCKD) Study von Kotsis, Fruzsina, Schultheiss, Ulla T, Wuttke, Matthias, Schlosser, Pascal, Mielke, Johanna, Becker, Michael S, Oefner, Peter J, Karoly, Edward D, Mohney, Robert P, Eckardt, Kai-Uwe, Sekula, Peggy, Köttgen, Anna

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Early Process Development of an Irreversible Epidermal Growth Factor Receptor (EGFR) T790 M Inhibitor von Tao, Yong, Keene, Nandell F, Wiglesworth, Kristin E, Sitter, Barbara, McWilliams, J. Christopher

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Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block von Goetz, Adam E, Becirovic, Husein, Blasberg, Florian, Chen, Bo, Clarke, Hugh J, Colombo, Matteo, Daddario, Pedro, Damon, David B, Depretz, Christelle, Dumond, Yves R, Grilli, Maria D, Han, Lu, Houck, Tim L, Johnson, Amber M, Jones, Kris N, Jung, Jörg, Leeman, Michel, Liu, Fangfang, Lu, Cuong V, Mangual, Emilio J, Nelson, Jade D, Puchlopek-Dermenci, Angela L. A, Ruggeri, Sally Gut, Simonds, Paul A, Sitter, Barbara, Virtue, Daniel E, Wang, Shuguang, Yu, Lixin, Yu, Tao

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Long-term outcomes of patients with IgA nephropathy in the German CKD cohort von Stamellou, Eleni, Nadal, Jennifer, Hendry, Bruce, Mercer, Alex, Seikrit, Claudia, Bechtel-Walz, Wibke, Schmid, Matthias, Moeller, Marcus J, Schiffer, Mario, Eckardt, Kai-Uwe, Kramann, Rafael, Floege, Jürgen

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Long-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort von Stamellou, Eleni, Nadal, Jennifer, Hendry, Bruce, Mercer, Alex, Bechtel-Walz, Wibke, Schiffer, Mario, Eckardt, Kai-Uwe, Kramann, Rafael, Moeller, Marcus J, Floege, Jürgen

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Associations of Urine and Plasma Metabolites with Kidney Failure and Death in a CKD Cohort von Steinbrenner, Inga, Schultheiss, Ulla T, Bächle, Helena, Cheng, Yurong, Behning, Charlotte, Schmid, Matthias, Yeo, Wan-Jin, Yu, Bing, Grams, Morgan E, Schlosser, Pascal, Stockmann, Helena, Gronwald, Wolfram, Oefner, Peter J, Schaeffner, Elke, Eckardt, Kai-Uwe, Köttgen, Anna, Sekula, Peggy

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Evaluation of Kilogram-Scale Sonagashira, Suzuki, and Heck Coupling Routes to Oncology Candidate CP-724,714 von Ripin, David H. Brown, Bourassa, Dennis E, Brandt, Thomas, Castaldi, Michael J, Frost, Heather N, Hawkins, Joel, Johnson, Phillip J, Massett, Stephen S, Neumann, Karin, Phillips, James, Raggon, Jeffery W, Rose, Peter R, Rutherford, Jennifer L, Sitter, Barbara, Stewart, A. Morgan, Vetelino, Michael G, Wei, Lulin

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