Mast cell signal transduction from the high-affinity IgE receptor von Siraganian, Reuben P

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Monomeric IgE Stimulates Signaling Pathways in Mast Cells that Lead to Cytokine Production and Cell Survival von Kalesnikoff, Janet, Huber, Michael, Lam, Vivian, Damen, Jacqueline E, Zhang, Juan, Siraganian, Reuben P, Krystal, Gerald

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Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor von Kihara, H, Siraganian, R P

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Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells von Zhang, J, Berenstein, E H, Evans, R L, Siraganian, R P

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Adrenomedullin Is a Cross-Talk Molecule that Regulates Tumor and Mast Cell Function during Human Carcinogenesis von Zudaire, Enrique, Martínez, Alfredo, Garayoa, Mercedes, Pío, Rubén, Kaur, Gurmeet, Woolhiser, Michael R., Metcalfe, Dean D., Hook, William A., Siraganian, Reuben P., Guise, Theresa A., Chirgwin, John M., Cuttitta, Frank

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Phosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibody von Zhang, J, Billingsley, M L, Kincaid, R L, Siraganian, R P

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Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases von Field, K A, Apgar, J R, Hong-Geller, E, Siraganian, R P, Baird, B, Holowka, D

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Point Mutation of a Tyrosine in the Linker Region of Syk Results in a Gain of Function von Sada, Kiyonao, Zhang, Juan, Siraganian, Reuben P

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Protein tyrosine kinase Syk in mast cell signaling von Siraganian, Reuben P, Zhang, Juan, Suzuki, Katsuhiro, Sada, Kiyonao

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The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE recepto... von Kimura, T, Sakamoto, H, Appella, E, Siraganian, R P

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Regulation of Protein Kinase Cβ I by Two Protein-Tyrosine Kinases, Btk and Syk von Kawakami, Yuko, Kitaura, Jiro, Hartman, Stephen E., Lowell, Clifford A., Siraganian, Reuben P., Kawakami, Toshiaki

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High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations von BENHAMOU, M, STEPHAN, V, ROBBINS, K. C, SIRAGANIAN, R. P

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The adapter molecule Gab2 regulates Fc epsilon RI-mediated signal transduction in mast cells von Xie, Zhi-Hui, Ambudkar, Indu, Siraganian, Reuben P

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Adherence of rat basophilic leukemia (RBL-2H3) cells to fibronectin- coated surfaces enhances secretion von Hamawy, MM, Oliver, C, Mergenhagen, SE, Siraganian, RP

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Tyrosine Phosphorylation Coupled to IgE Receptor-Mediated Signal Transduction and Histamine Release von Benhamou, Marc, Gutkind, J. Silvio, Robbins, Keith C., Siraganian, Reuben P.

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The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31) von Sagawa, Kenji, Kimura, Teruaki, Swieter, Mark, Siraganian, Reuben P.

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Mutations in the Activation Loop Tyrosines of Protein Tyrosine Kinase Syk Abrogate Intracellular Signaling But Not Kinase Activity von Zhang, Juan, Kimura, Teruaki, Siraganian, Reuben P

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Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens von Kashiwakura, Jun-Ichi, Okayama, Yoshimichi, Furue, Masutaka, Kabashima, Kenji, Shimada, Shinji, Ra, Chisei, Siraganian, Reuben P, Kawakami, Yuko, Kawakami, Toshiaki

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Dual role of the CD44 molecule in T cell adhesion and activation von Shimizu, Y, Van Seventer, GA, Siraganian, R, Wahl, L, Shaw, S

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Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells von Xie, Z H, Zhang, J, Siraganian, R P

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