WS09.4 Novel disease models to capture pathological complexity of Pseudomonas aeruginosa respiratory infection von Lorè, N.I, Sipione, B, Mott, R, Iraqi, F, Bragonzi, A

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165 Modeling polymicrobial infections in the pathogenesis of cystic fibrosis lung disease von Cigana, C, Bianconi, I, De Simone, M, Riva, C, Baldan, R, Sipione, B, Cirillo, D.M, Bragonzi, A

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WS10.5 Pseudomonas aeruginosa adaptation as a potential risk factor to the progression of cystic fibrosis airway disease in mice and humans von Cigana, C, Lorè, N.I, Riva, C, De Fino, I, Cariani, L, Spagnuolo, L, Sipione, B, Rossi, G, Colombo, C, Bragonzi, A

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586 ΔF508–cystic fibrosis transmembrane conductance regulator mutation in C57BL/6 and Collaborative Cross mice to unravel the contribution of genetic background in the cystic fibro... von Neri, A., Gianferro, F., Cigana, C., Tascini, A., Sipione, B., Lore, N., Rossi, G., Sanvito, F., Bragonzi, A.

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WS07.3 Phenotypic and genotypic characterisation of a novel mouse model of F508del-CFTR in genetically diverse collaborative cross von Sipione, B., Lorè, N.I., Rossi, G., Sanvito, F., D'Aurora, M., Bragonzi, A.

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674: ΔF508-CFTR mutation in genetically diverse collaborative cross mice expands CF disease-relevant phenotypes von Sipione, B., Lorè, N., Rossi, G., Sanvito, F., D’Aurora, M., Neri, A., Gianferro, F., Cigana, C., Bragonzi, A.

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P187 Unravelling the contribution to the pro-inflammatory burden caused by the persistence of nontypeable haemophilus influenzae in cystic fibrosis von Saliu, F., Rizzo, G., Sipione, B., Rizzetto, S., Cariani, L., Cirillo, D.M., Bragonzi, A., Cigana, C., Lore’, N.I.

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WS04.1 Targeting IL-17-producing T-cells attenuates the severity of Pseudomonas aeruginosa lung infection von Lorè, N.I., Sipione, B., Melessike, M., Mertz, J.A., Kolls, J.K., Bragonzi, A., Cigana, C.

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Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease von Lorè, NI, Sipione, B, He, G, Strug, LJ, Atamni, HJ, Dorman, A, Mott, R, Iraqi, FA, Bragonzi, A

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Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease von Zuccato, Chiara, Ciammola, Andrea, Rigamonti, Dorotea, Leavitt, Blair R., Goffredo, Donato, Conti, Luciano, MacDonald, Marcy E., Friedlander, Robert M., Silani, Vincenzo, Hayden, Michael R., Timmusk, Tõnis, Sipione, Simonetta, Cattaneo, Elena

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Disease‐modifying effects of ganglioside GM1 in Huntington's disease models von Alpaugh, Melanie, Galleguillos, Danny, Forero, Juan, Morales, Luis Carlos, Lackey, Sebastian W, Kar, Preeti, Di Pardo, Alba, Holt, Andrew, Kerr, Bradley J, Todd, Kathryn G, Baker, Glen B, Fouad, Karim, Sipione, Simonetta

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Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease von Valenza, Marta, Rigamonti, Dorotea, Goffredo, Donato, Zuccato, Chiara, Fenu, Simone, Jamot, Laure, Strand, Andrew, Tarditi, Alessia, Woodman, Ben, Racchi, Marco, Mariotti, Caterina, Di Donato, Stefano, Corsini, Alberto, Bates, Gillian, Pruss, Rebecca, Olson, James M, Sipione, Simonetta, Tartari, Marzia, Cattaneo, Elena

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Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease von Lore, Nicola Ivan, Sipione, Barbara, He, Gengming, Strug, Lisa J., Atamni, Hanifa J., Dorman, Alexandra, Mott, Richard, Iraqi, Fuad A., Bragonzi, Alessandra

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Intrinsically Self-renewing Neuroprogenitors From the A/J Mouse Spiral Ganglion as Virtually Unlimited Source of Mature Auditory Neurons von Rousset, Francis, Kokje, Vivianne B. C., Sipione, Rebecca, Schmidbauer, Dominik, Nacher-Soler, German, Ilmjaerv, Sten, Coelho, Marta, Fink, Stefan, Voruz, Francois, El Chemaly, Antoun, Marteyn, Antoine, Loewenheim, Hubert, Krause, Karl-Heinz, Mueller, Marcus, Glueckert, Rudolf, Senn, Pascal

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Shc signaling in differentiating neural progenitor cells von Cattaneo, Elena, Conti, Luciano, Sipione, Simonetta, Magrassi, Lorenzo, Bonfanti, Luca, Rigamonti, Dorotea, Pettirossi, Valentina, Peschanski, Marc, Haddad, Bassam, Pelicci, PierGiuseppe, Milanesi, Gabriele, Pelicci, Giuliana

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ST14A Cells Have Properties of a Medium-Size Spiny Neuron von Ehrlich, Michelle E., Conti, Luciano, Toselli, Mauro, Taglietti, Luca, Fiorillo, Edgardo, Taglietti, Vanni, Ivkovic, Sanja, Guinea, Barbara, Tranberg, Anna, Sipione, Simonetta, Rigamonti, Dorotea, Cattaneo, Elena

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A19 Early defect of transforming growth factor [beta]1 formation in Huntington's disease von Squitieri, F, Battaglia, G, Cannella, M, Riozzi, B, Orobello, S, Maat-Schieman, M L, Aronica, E, Busceti, C L, Ciarmiello, A, Alberti, S, Sassone, J, Sipione, S, Bruno, V, Frati, L, Nicoletti, F

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A19 Early defect of transforming growth factor β1 formation in Huntington's disease von Squitieri, F, Battaglia, G, Cannella, M, Riozzi, B, Orobello, S, Maat-Schieman, M L, Aronica, E, Busceti, C L, Ciarmiello, A, Alberti, S, Sassone, J, Sipione, S, Bruno, V, Frati, L, Nicoletti, F

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Platform presentation—Early Defect of Transforming Growth Factor β1 Formation in Huntington's Disease von Battaglia, G., Cannella, M., Riozzi, B., Orobello, S., Maat-Schieman, M.L., Aronica, E., Busceti, C. Letizia, Ciarmiello, A., Alberti, S., Sassone, J., Sipione, S., Bruno, V., Frati, L., Nicoletti, F., Squitieri, F.

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Poster 7: Early Defect of Transforming Growth Factor β1 Formation in Huntington's Disease von Battaglia, G., Cannella, M., Riozzi, B., Orobello, S., Maat-Schieman, M.L., Aronica, E., Busceti, C. Letizia, Ciarmiello, A., Alberti, S., Sassone, J., Sipione, S., Bruno, V., Frati, L., Nicoletti, F., Squitieri, F.

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