Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models von Singh Mali, Raghuveer, Zhang, Qi, DeFilippis, Rosa Anna, Cavazos, Antonio, Kuruvilla, Vinitha Mary, Raman, Jayant, Mody, Vidhi, Choo, Edna F, Dail, Monique, Shah, Neil P, Konopleva, Marina, Sampath, Deepak, Lasater, Elisabeth A

Volltext

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL von Mali, Raghuveer Singh, Ramdas, Baskar, Ma, Peilin, Shi, Jianjian, Munugalavadla, Veerendra, Sims, Emily, Wei, Lei, Vemula, Sasidhar, Nabinger, Sarah C., Goodwin, Charles B., Chan, Rebecca J., Traina, Fabiola, Visconte, Valeria, Tiu, Ramon V., Lewis, Timothy A., Stern, Andrew M., Wen, Qiang, Crispino, John D., Boswell, H. Scott, Kapur, Reuben

Volltext

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis von Chatterjee, Anindya, Ghosh, Joydeep, Ramdas, Baskar, Mali, Raghuveer Singh, Martin, Holly, Kobayashi, Michihiro, Vemula, Sasidhar, Canela, Victor H., Waskow, Emily R., Visconte, Valeria, Tiu, Ramon V., Smith, Catherine C., Shah, Neil, Bunting, Kevin D., Boswell, H. Scott, Liu, Yan, Chan, Rebecca J., Kapur, Reuben

Volltext

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT von Mali, Raghuveer Singh, Ma, Peilin, Zeng, Li-Fan, Martin, Holly, Ramdas, Baskar, He, Yantao, Sims, Emily, Nabinger, Sarah, Ghosh, Joydeep, Sharma, Namit, Munugalavadla, Veerendra, Chatterjee, Anindya, Li, Shuo, Sandusky, George, Craig, Andrew W., Bunting, Kevin D., Feng, Gen-Sheng, Chan, Rebecca J., Zhang, Zhong-Yin, Kapur, Reuben

Volltext

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis von Cai, Zhigang, Kotzin, Jonathan J., Ramdas, Baskar, Chen, Sisi, Nelanuthala, Sai, Palam, Lakshmi Reddy, Pandey, Ruchi, Mali, Raghuveer Singh, Liu, Yan, Kelley, Mark R., Sandusky, George, Mohseni, Morvarid, Williams, Adam, Henao-Mejia, Jorge, Kapur, Reuben

Volltext

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor von Ma, Peilin, Mali, Raghuveer Singh, Munugalavadla, Veerendra, Krishnan, Subha, Ramdas, Baskar, Sims, Emily, Martin, Holly, Ghosh, Joydeep, Li, Shuo, Chan, Rebecca J., Krystal, Gerald, Craig, Andrew W., Takemoto, Clifford, Kapur, Reuben

Volltext

Targeting MCL‐1 and BCL‐2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non‐Hodgkin lymphoma: Results from preclinical models and a Phase Ib study... von Lasater, Elisabeth A., Amin, Dhara N., Bannerji, Rajat, Mali, Raghuveer Singh, Barrett, Kathy, Rys, Ryan N., Oeh, Jason, Lin, Eva, Sterne‐Weiler, Tim, Ingalla, Ellen Rei, Go, MaryAnn, Yu, Shang‐Fan, Krem, Maxwell M., Arthur, Chris, Hahn, Uwe, Johnston, Anna, Karur, Vinit, Khan, Nadia, Marlton, Paula, Phillips, Tycel, Gritti, Giuseppe, Seymour, John F., Tani, Monica, Yuen, Sam, Martin, Scott, Chang, Matthew T., Rose, Christopher M., Pham, Victoria C., Polson, Andrew G., Chang, YiMeng, Wever, Claudia, Johnson, Nathalie A., Jiang, Yanwen, Hirata, Jamie, Sampath, Deepak, Musick, Lisa, Flowers, Christopher R., Wertz, Ingrid E.

Volltext

Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis von Traina, Fabiola, Visconte, Valeria, Jankowska, Anna M, Makishima, Hideki, O'Keefe, Christine L, Elson, Paul, Han, Yingchun, Hsieh, Fred H, Sekeres, Mikkael A, Mali, Raghuveer Singh, Kalaycio, Matt, Lichtin, Alan E, Advani, Anjali S, Duong, Hien K, Copelan, Edward, Kapur, Reuben, Olalla Saad, Sara T, Maciejewski, Jaroslaw P, Tiu, Ramon V

Volltext

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms von Martin, Holly, Mali, Raghuveer Singh, Ma, Peilin, Chatterjee, Anindya, Ramdas, Baskar, Sims, Emily, Munugalavadla, Veerendra, Ghosh, Joydeep, Mattingly, Ray R, Visconte, Valeria, Tiu, Ramon V, Vlaar, Cornelis P, Dharmawardhane, Suranganie, Kapur, Reuben

Volltext

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53 von Vemula, Sasidhar, Shi, Jianjian, Mali, Raghuveer Singh, Ma, Peilin, Liu, Yan, Hanneman, Philip, Koehler, Karl R., Hashino, Eri, Wei, Lei, Kapur, Reuben

Volltext

Combined heterozygosity of FLT3ITD, TET2, and DNMT3A results in aggressive leukemia von Baskar Ramdas, Palam Lakshmi Reddy, Raghuveer Singh Mali, Santhosh Kumar Pasupuleti, Ji Zhang, Mark R. Kelley, Sophie Paczesny, Chi Zhang, Reuben Kapur

Volltext

SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice von Sharma, Namit, Kumar, Vijay, Everingham, Stephanie, Mali, Raghuveer Singh, Kapur, Reuben, Zeng, Li-Fan, Zhang, Zhong-Yin, Feng, Gen-Sheng, Hartmann, Karin, Roers, Axel, Craig, Andrew W. B.

Volltext

p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis von Krishnan, Subha, Mali, Raghuveer Singh, Ramdas, Baskar, Sims, Emily, Ma, Peilin, Ghosh, Joydeep, Munugalavadla, Veerendra, Hanneman, Philip, Beane, Joal D., Kapur, Reuben

Volltext

The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells von Ruschmann, Jens, Antignano, Frann, Lam, Vivian, Snyder, Kim, Kim, Connie, Essak, Martha, Zhang, Angela, Lin, Ann Hsu-An, Mali, Raghuveer Singh, Kapur, Reuben, Krystal, Gerald

Volltext

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway von Palam, Lakshmi Reddy, Mali, Raghuveer Singh, Ramdas, Baskar, Srivatsan, Sridhar Nonavinkere, Visconte, Valeria, Tiu, Ramon V, Vanhaesebroeck, Bart, Roers, Axel, Gerbaulet, Alexander, Xu, Mingjiang, Janga, Sarath Chandra, Takemoto, Clifford M, Paczesny, Sophie, Kapur, Reuben

Volltext

Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes von Krishnan, Subha, Mali, Raghuveer Singh, Koehler, Karl R, Vemula, Sasidhar, Chatterjee, Anindya, Ghosh, Joydeep, Ramdas, Baskar, Ma, Peilin, Hashino, Eri, Kapur, Reuben

Volltext

Class IA PI3Kinase Regulatory Subunit, p85α, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes von Krishnan, Subha, Mali, Raghuveer Singh, Koehler, Karl R., Vemula, Sasidhar, Chatterjee, Anindya, Ghosh, Joydeep, Ramdas, Baskar, Ma, Peilin, Hashino, Eri, Kapur, Reuben

Volltext

Balanced Interactions between Lyn, the p85α Regulatory Subunit of Class IA Phosphatidylinositol-3-Kinase, and SHIP Are Essential for Mast Cell Growth and Maturation von Ma, Peilin, Vemula, Sasidhar, Munugalavadla, Veerendra, Chen, Jinbiao, Sims, Emily, Borneo, Jovencio, Kondo, Takako, Ramdas, Baskar, Mali, Raghuveer Singh, Li, Shuo, Hashino, Eri, Takemoto, Clifford, Kapur, Reuben

Volltext

Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibito... von Ramdas, Baskar, Palam, Lakshmi Reddy, Mali, Raghuveer Singh, Cai, Zhigang, Pandey, Ruchi, Kapur, Reuben

Volltext

Role of Rho kinases in abnormal and normal hematopoiesis von Mali, Raghuveer Singh, Kapur, Simryn, Kapur, Reuben

Volltext