A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity von Kostadinova, Radina, Boess, Franziska, Applegate, Dawn, Suter, Laura, Weiser, Thomas, Singer, Thomas, Naughton, Brian, Roth, Adrian

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The Immunogenicity of Antibody Aggregates in a Novel Transgenic Mouse Model von Bessa, Juliana, Boeckle, Sabine, Beck, Hermann, Buckel, Thomas, Schlicht, Sonja, Ebeling, Martin, Kiialainen, Anna, Koulov, Atanas, Boll, Björn, Weiser, Thomas, Singer, Thomas, Rolink, Antonius G., Iglesias, Antonio

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Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro von Nguyen, Deborah G, Funk, Juergen, Robbins, Justin B, Crogan-Grundy, Candace, Presnell, Sharon C, Singer, Thomas, Roth, Adrian B

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Scales of Lewis Basicities toward C‑Centered Lewis Acids (Carbocations) von Mayr, Herbert, Ammer, Johannes, Baidya, Mahiuddin, Maji, Biplab, Nigst, Tobias A, Ofial, Armin R, Singer, Thomas

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Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment von Ebeling, Martin, Küng, Erich, See, Angela, Broger, Clemens, Steiner, Guido, Berrera, Marco, Heckel, Tobias, Iniguez, Leonardo, Albert, Thomas, Schmucki, Roland, Biller, Hermann, Singer, Thomas, Certa, Ulrich

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Brain Shuttle Antibody for Alzheimer’s Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode von Weber, Felix, Bohrmann, Bernd, Niewoehner, Jens, Fischer, Jens A.A., Rueger, Petra, Tiefenthaler, Georg, Moelleken, Joerg, Bujotzek, Alexander, Brady, Kevin, Singer, Thomas, Ebeling, Martin, Iglesias, Antonio, Freskgård, Per-Ola

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A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides von Dieckmann, Andreas, Hagedorn, Peter H., Burki, Yvonne, Brügmann, Christine, Berrera, Marco, Ebeling, Martin, Singer, Thomas, Schuler, Franz

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Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia von Sewing, Sabine, Roth, Adrian B, Winter, Michael, Dieckmann, Andreas, Bertinetti-Lapatki, Cristina, Tessier, Yann, McGinnis, Claudia, Huber, Sylwia, Koller, Erich, Ploix, Corinne, Reed, John C, Singer, Thomas, Rothfuss, Andreas

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Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies von Kerns, S. Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B., Hamilton, Geraldine A., Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane

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Nucleophilicities and Carbon Basicities of Pyridines von Brotzel, Frank, Kempf, Bernhard, Singer, Thomas, Zipse, Hendrik, Mayr, Herbert

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Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs von Sewing, Sabine, Boess, Franziska, Moisan, Annie, Bertinetti-Lapatki, Cristina, Minz, Tanja, Hedtjaern, Maj, Tessier, Yann, Schuler, Franz, Singer, Thomas, Roth, Adrian B

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Culture and Drug Profiling of Patient Derived Malignant Pleural Effusions for Personalized Cancer Medicine von Ruiz, Christian, Kustermann, Stefan, Pietilae, Elina, Vlajnic, Tatjana, Baschiera, Betty, Arabi, Leila, Lorber, Thomas, Oeggerli, Martin, Savic, Spasenija, Obermann, Ellen, Singer, Thomas, Rothschild, Sacha I, Zippelius, Alfred, Roth, Adrian B, Bubendorf, Lukas

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Application of Imaging Techniques to Cases of Drug-Induced Crystal Nephropathy in Preclinical Studies von Lenz, Barbara, Brink, Andreas, Siam, Monira, De Paepe, Anne, Bassett, Simon, Eichinger-Chapelon, Anne, Maliver, Pierre, Neff, Rachel, Niederhauser, Urs, Steinhuber, Bernd, Zurbach, Raphael, Singer, Thomas, Funk, Christoph, Schuler, Franz, Albassam, Mudher, Schadt, Simone

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The application of 3D cell models to support drug safety assessment: Opportunities & challenges von Roth, Adrian, Singer, Thomas

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EMS in Viracept—The course of events in 2007 and 2008 from the non-clinical safety point of view von Müller, Lutz, Singer, Thomas

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In Silico Assay for Assessing Phospholipidosis Potential of Small Druglike Molecules: Training, Validation, and Refinement Using Several Data Sets von Fischer, Holger, Atzpodien, Elke-Astrid, Csato, Miklos, Doessegger, Lucette, Lenz, Barbara, Schmitt, Georg, Singer, Thomas

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Local boundedness of weak solutions to the Diffusive Wave Approximation of the Shallow Water equations von Singer, Thomas, Vestberg, Matias

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The Meshugana Complex: Notes from a Big Galoot Galut von Singer, Thomas

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Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration von Zheng, Yanan, Tesar, Devin B., Benincosa, Lisa, Birnböck, Herbert, Boswell, C. Andrew, Bumbaca, Daniela, Cowan, Kyra J, Danilenko, Dimitry M., Daugherty, Ann L., Fielder, Paul J., Grimm, Hans Peter, Joshi, Amita, Justies, Nicole, Kolaitis, Gerry, Lewin-Koh, Nicholas, Li, Jing, McVay, Sami, O'Mahony, Jennifer, Otteneder, Michael, Pantze, Michael, Putnam, Wendy S., Qiu, Zhihua J., Ruppel, Jane, Singer, Thomas, Stauch, Oliver, Theil, Frank-Peter, Visich, Jennifer, Yang, Jihong, Ying, Yong, Khawli, Leslie A., Richter, Wolfgang F.

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Existence of weak solutions of parabolic systems with p, q-growth von Singer, Thomas

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