Genome-wide association study to identify genetic determinants of severe asthma von Wan, Y I, Shrine, N R G, Soler Artigas, M, Wain, L V, Blakey, J D, Moffatt, M F, Bush, A, Chung, K F, Cookson, W O C M, Strachan, D P, Heaney, L, Al-Momani, B A H, Mansur, A H, Manney, S, Thomson, N C, Chaudhuri, R, Brightling, C E, Bafadhel, M, Singapuri, A, Niven, R, Simpson, A, Holloway, J W, Howarth, P H, Hui, J, Musk, A W, James, A L, Brown, M A, Baltic, S, Ferreira, M A R, Thompson, P J, Tobin, M D, Sayers, I, Hall, I P

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A microbiome assessment of medical marijuana von Thompson, G.R., Tuscano, J.M., Dennis, M., Singapuri, A., Libertini, S., Gaudino, R., Torres, A., Delisle, J.M.P., Gillece, J.D., Schupp, J.M., Engelthaler, D.M.

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Clinical significance of small airway obstruction markers in patients with asthma von Gonem, S., Natarajan, S., Desai, D., Corkill, S., Singapuri, A., Bradding, P., Gustafsson, P., Costanza, R., Kajekar, R., Parmar, H., Brightling, C. E., Siddiqui, S.

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Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study von Fuld, J, Jenkins, R G, Man, W D-C, Openshaw, P J M, Scott, J T, Quint, J, Thorpe, M, Poinasamy, K, Harrison, E M, Ainsworth, M, Amoils, S, Armstrong, L, Atkin, C, Bain, S, Bates, A, Beckett, P, Bennett, K, Betts, S, Bhui, K, Brown, V, Buckley, P, Carr, C, Childs, C, Choudhury, N, Clohisey, S, Coakley, G, Cosier, T, Cuthbertson, D, Daly, P, Davies, G A, Davies, K, Dowling, R, Drury, K, Dunleavy, A, Evans, H, Evans, R, Finch, J, Fletcher, S, Francis, S, Frankel, A, Fu, X, Gooptu, B, Gregory, R, Hadley, K, Hall, L, Hanley, N A, Hazeldine, J, Heeley, C, Hiwot, T, Ismail, K, James, W Y, Jones, G, Kanellakis, N, Kelly, S, Kemp, G, Knight, S, Laing, C, Lea, A, Lingford-Hughes, A, Lota, H, Lye, A, Majeed, N, Mariveles, M, McArdle, A, McGarvey, L, McGinness, J, McGuinness, H, Monteiro, W, Needham, R, Neill, P, Newton-Cox, A, Noonan, M J, Norman, C, Nyaboko, J, O'Brien, L, Ostermann, M, Papineni, P, Patel, M, Powell, N, Price, L, Propescu, J, Rangeley, J, Redwood, D, Ross, A, Rossdale, J, Rowland, J, Sharma, M, Shaw, A, Shaw, K, Singh, S, Smith, D, Sykes, R, Thompson, A A R, Tomlinson, J, Tripp, K A, Ventura, M, Wight, A, Wilkinson, D, Willicombe, M, Young, S

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S80 Localisation of the site of fixed airflow obstruction in moderate to severe asthma using hyperpolarised helium-3 MRI von Gonem, S, Ball, I, Corkill, S, Desai, D, Singapuri, A, Gustafsson, P, Owers-Bradley, J, Brightling, C, Siddiqui, S

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S83 Repeatability and inter-relationships of small airway biomarkers von Gonem, S, Ball, I, Corkill, S, Desai, D, Singapuri, A, Gustafsson, P, Owers-Bradley, J, Brightling, C, Siddiqui, S

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P123 Impulse oscillometry (IOS) indices in severe asthma and healthy controls after deep breath manoeuvres and bronchodilator administration von Umar, I, Desai, D, Corkill, S, Shelley, M, Singapuri, A, Brightling, C, Siddiqui, S

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P122 The use of impulse oscillometry (IOS) to study fractal scaling and sample entropy in airway resistance time series in severe asthma von Umar, I, Desai, D, Corkill, S, Shelley, M, Singapuri, A, Brightling, C, Siddiqui, S

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Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study von Baillie, J K, Jones, S, Young, Susan, Jarrold, I, Manisty, Charlotte, Brown, V, Southern, David, Roberts, K, Whitehead, Victoria, Regan, Karen, Ribeiro, Carla, Cruz, Isabel, Paradowski, Kerry, Broad, Lauren, Knibbs, Lucy, Rees, Meryl, Keenan, Natalie, Hazelton, Tracy, Wilson, Ann, Arbane, Gill, Solano, Teresa S, Ellis, Y, Sykes, D L, Wolf-Roberts, Rebecca, King, Clara, Nunag, Jose Lloyd, Evison, Lynsey, Yasmin, Najira, Wilkins, M, Ismail, K, Greenwood, John P, Murira, Jennifer, Dalton, Matthhew, Allt, Ann Marie, Malein, Flora, Melling, Lucy, Greenhalf, William, Faluyi, David, Choudhury, N, Stockdale, Sue, Paddick, S, Burn, D, Price, D, Davies, Gareth, Hughes, Joan, Thomas, S, Dougherty, Andrew, Morrow, A, Barrett, Fiona, Rowland, J, Francis, Susan, Hosseini, A, Pavlides, M, Jezzard, Peter, Barker, R E, Kon, S, Singh, Suver, Paques, K, Chan, Flora, Foot, H, Birchall, K, Steele, N, Holbourn, Ailsa, Zawia, Amira, Thamu, B, Foote, David, Stephens, G, Wade, Phillip, Rowland-Jones, Sarah L, Painter, Sharon, Aul, Raminder, Rees, Tabitha, Savill, Heather, Aslani, S, Plant, Hannah, Porter, Joanna C, Roy, K, Yip, K P, Ventura, M, Holden, S, Harvey, M, Fletcher, S, Steeds, Rick, Prickett, A, Mills, G, Soares, M, Allan, L, Cavanagh, J, Sattar, N, Guillen Guio, Beatriz, Sargant, J, Novotny, Petr, Baguley, D, Johnson, S, Menke, Ricarda, Miller, Karla, Daines, L, Reddington, A, Brookes, C, Ionita, D

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Long COVID research: an update from the PHOSP-COVID Scientific Summit von Brightling, Christopher E, Evans, Rachael A, Singapuri, Amisha, Smith, Nikki, Wain, Louise V

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S121 Mediator profiling of severe asthma phenotypes von Desai, D, Newby, C J, Haldar, P, Shah, S, Gupta, S, Bafadhel, M, Singapuri, A, Siddiqui, S, Woods, J, Herath, A, Anderson, I K, Bradding, P, Green, R H, Wardlaw, A J, Pavord, I D, May, R D, Brightling, C E

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P17 Self-reported physical activity levels and attitudes towards a structured exercise programme in adults with difficult asthma von Singapuri, A, Singh, SJ, Hargadon, B, Shelley, M, Desai, D, Carter, R, Brightling, CE, Pavord, ID, Bradding, P, Wardlaw, AJ, Green, RH

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Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study von Houchen-Wolloff, Linzy, Jolley, Caroline J, Leavy, Olivia C, Piper-Hanley, Karen, Saunders, Ruth M, Cunningham, P S, Chalder, T, Donaldson, G, Edwardson, C L, Greening, N J, Jolley, C J, McAuley, H J C, Thorpe, M, Amoils, S, Aslani, S, Avram, C, Bailey, L, Barrett, F, Basire, D, Beggs, M, Bourne, C, Brown, A, Channon, K M, Charalambou, A, Chilvers, E R, Chong-James, K, Chrystal, M, Cooper, B, Cooper, J, Cooper, S, Craig, T, Cruz, I, Dempsey, K, Djukanovic, R, Evans, J, Finch, J, Francis, S, Frankel, A, French, N, Hardy, E, Hardy, T, Hockridge, J, Howard, K, Hufton, E, Hussell, T, Ilyas, F, Ingham, J, Jones, H, Kirk, J, Langenberg, C, Mariveles, M, Maskell, N, McArdle, A, McCormick, J, McCourt, P, McGinness, J, McNarry, M, Mehta, P, Menzies, D, Moss, P, Needham, R, Neill, P, Neubauer, S, Novotny, P, Openshaw, P J M, Owen, J, Price, D, Propescu, J, Qureshi, I N, Rees, M, Regan, K, Ribeiro, C, Ross, G, Sabit, R, Samakomva, T, Samuel, R, Sapey, E, Selby, N, Semple, M G, Short, J, Smith, L, Stringer, E, Summersgill, C, Tench, H, Thomas-Woods, T, Tomlinson, J, Tripp, K A, Turner, S, Turney, S, Wallis, T, Weir McCall, J, Whitehead, V, Whittaker, S, Williams, J, Williams-Howard, S A, Wood, C, Wraith, D, Xu, M, Zhao, B, Zheng, B

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Calmodulin concentrates at the apex of growing hyphae and localizes to the Spitzenkörper in Aspergillus nidulans von Wang, G, Lu, L, Zhang, C.-Y, Singapuri, A, Yuan, S

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A Large-Scale, Consortium-Based Genomewide Association Study of Asthma von Moffatt, Miriam F, Gut, Ivo G, Demenais, Florence, Strachan, David P, Bouzigon, Emmanuelle, Heath, Simon, von Mutius, Erika, Farrall, Martin, Lathrop, Mark, Cookson, William O.C.M

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Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury von Taquet, Maxime, Skorniewska, Zuzanna, Zetterberg, Henrik, Geddes, John R, Mummery, Catherine J, Chalmers, James D, Ho, Ling-Pei, Horsley, Alex, Marks, Michael, Poinasamy, Krisnah, Raman, Betty, Leavy, Olivia C, Richardson, Matthew, Elneima, Omer, McAuley, Hamish J C, Shikotra, Aarti, Singapuri, Amisha, Sereno, Marco, Saunders, Ruth M, Harris, Victoria Claire, Houchen-Wolloff, Linzy, Mansoori, Parisa, Greening, Neil J, Harrison, Ewen M, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Greenhalf, William, Wain, Louise V, Brightling, Christopher E, Evans, Rachael E, Harrison, Paul J, Koychev, Ivan

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P185 Urine biomarker profiles associated with copd exacerbations von Yousuf, A, Parekh, G, Watson, L, George, L, Singapuri, A, Mistry, V, Davis, P, Brightling, C

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Large scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease von Efstathiou, C, Liew, F, Fontanella, S, Richardson, M, Saunders, R, Swieboda, D, Sidhu, J, Ascough, S, Moore, S, Mohamed, N, Nunag, J, King, C, Leavy, O, Elneima, O, McAuley, H, Shikotra, A, Singapuri, A, Sereno, M, Harris, V, Houchen-Wolloff, L, Greening, N, Lone, N, Thorpe, M, Thompson, AAR, Rowland-Jones, S, Docherty, A, Chalmers, J, Ho, L-P, Horsley, A, Ramam, B, Poinasamy, K, Marks, M, Kon, OM, Howard, L, Wootton, D, Quint, J, De Silva, T, Ho, A, Chiu, C, Harrision, E, Greenhalf, W, Baillie, JK, Semple, M, Turtle, L, Evans, R, Wain, L, Brightling, C, Thwaites, R, Openshaw, P

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Visualization of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness von Ibrahim, W, Wilde, MJ, Cordell, RL, Richardson, M, Salman, D, Free, RC, Zhao, B, Singapuri, A, Hargadon, B, Gaillard, EA, Suzuki, T, Ng, LL, Coats, T, Thomas, P, Monks, PS, Brightling, CE, Greening, NJ, Siddiqui, S, EMBER, C

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Long COVID and cardiovascular disease: a prospective cohort study von Berry, Colin, McAuley, Hamish JC, Shikotra, Aarti, Horsley, Alex, McShane, H, Parkes, M, Ashworth, M, Daines, L, Lone, N I, Wild, J M, Miller, C A, O’Brien, C, Steeds, R, Webster, M, Jenkins, R G, Shaw, T, Adeloye, D, Burn, D, Cavanagh, J, Clark, D, Evans, J, Hosseini, A, Mills, N L, Sudlow, C L, Efstathiou, C M, Klenerman, P, Lord, J M, Summers, C, Fabbri, L, Smith, D, Thickett, D, Atkins, H, Bain, S, Dennis, J, Shah, K, Gardiner, L, Shenton, L, Willis, G, Bolger, A, Saralaya, D, Elmer, A, Taylor, J, Sabit, R, Evans, T, Williams, J, Bradley-Potts, J, Cosier, T, Hazelton, T, Aguilar Jimenez, LA, Kaltsakas, G, Wright, C, Coetzee, S, Davies, K, Phipps, J, Haq, S, Moriera, S, Nunag, J, Nwanguma, U, Reddy, R, Warwick, K, Jolley, C J, Whittam, B, Woods, J, Richardson, E, Papineni, P, Barran, P, Odell, N, Burns, G, Hughes, J, Jones, G, Thomas, S, Anderson, D, Brown, A, Fallon, K, Bell, D, Quigley, J, Newby, D E, Sutherland, D, Morley, A, Light, T, Rahman, N M, Ainsworth, M, Man, WDC, Shah, P, Brill, S, Olaosebikan, O, Oxton, J, Lee, E, Lee, J-H, Stimpson, R, Wade, P, Sissons, D, Vickers, C, Wainwright, T, McCormick, J, Ugoji, J, Hillman, T, Neal, A, Charalambou, A, Diver, S

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