Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge von Ming, Mei, PhD, Zhao, Baozhong, PhD, Shea, Christopher R., MD, Shah, Palak, MB, Qiang, Lei, PhD, White, Steven R., MD, Sims, Diane M., BS, He, Yu-Ying, PhD

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Sestrin2 Protein Positively Regulates AKT Enzyme Signaling and Survival in Human Squamous Cell Carcinoma and Melanoma Cells von Zhao, Baozhong, Shah, Palak, Budanov, Andrei V., Qiang, Lei, Ming, Mei, Aplin, Andrew, Sims, Diane M., He, Yu-Ying

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A personal triumph von Sims, Diane

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I-123 Whole Body Scanning: Case Report and Discussion von Klein, Herbert A, DiSibio, Kenneth J, Sims, Diane, Singleton, Helen C, Worthy, Lois J

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How I Plan to Die von Sims, Diane

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How I Plan to Die: Preparing for MAID is exhausting and expensive. I’m glad I lived long enough to do it von Sims, Diane

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Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling von Eyre, Rachel, Alférez, Denis G., Santiago-Gómez, Angélica, Spence, Kath, McConnell, James C., Hart, Claire, Simões, Bruno M., Lefley, Diane, Tulotta, Claudia, Storer, Joanna, Gurney, Austin, Clarke, Noel, Brown, Mick, Howell, Sacha J., Sims, Andrew H., Farnie, Gillian, Ottewell, Penelope D., Clarke, Robert B.

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Efficacy of a Just-in-Time Adaptive Intervention to Promote HIV Risk Reduction Behaviors Among Young Adults Experiencing Homelessness: Pilot Randomized Controlled Trial von Santa Maria, Diane, Padhye, Nikhil, Businelle, Michael, Yang, Yijiong, Jones, Jennifer, Sims, Alexis, Lightfoot, Marguerita

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Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway von Lojewski, Xenia, Staropoli, John F, Biswas-Legrand, Sunita, Simas, Alexandra M, Haliw, Larissa, Selig, Martin K, Coppel, Scott H, Goss, Kendrick A, Petcherski, Anton, Chandrachud, Uma, Sheridan, Steven D, Lucente, Diane, Sims, Katherine B, Gusella, James F, Sondhi, Dolan, Crystal, Ronald G, Reinhardt, Peter, Sterneckert, Jared, Schöler, Hans, Haggarty, Stephen J, Storch, Alexander, Hermann, Andreas, Cotman, Susan L

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways von Cirulli, Elizabeth T., Lasseigne, Brittany N., Petrovski, Slavé, Sapp, Peter C., Dion, Patrick A., Leblond, Claire S., Couthouis, Julien, Lu, Yi-Fan, Wang, Quanli, Krueger, Brian J., Ren, Zhong, Keebler, Jonathan, Han, Yujun, Levy, Shawn E., Boone, Braden E., Wimbish, Jack R., Waite, Lindsay L., Jones, Angela L., Carulli, John P., Day-Williams, Aaron G., Staropoli, John F., Xin, Winnie W., Chesi, Alessandra, Raphael, Alya R., McKenna-Yasek, Diane, Cady, Janet, de Jong, J. M. B. Vianney, Kenna, Kevin P., Smith, Bradley N., Topp, Simon, Miller, Jack, Gkazi, Athina, Al-Chalabi, Ammar, van den Berg, Leonard H., Veldink, Jan, Silani, Vincenzo, Ticozzi, Nicola, Shaw, Christopher E., Baloh, Robert H., Appel, Stanley, Simpson, Ericka, Lagier-Tourenne, Clotilde, Pulst, Stefan M., Gibson, Summer, Trojanowski, John Q., Elman, Lauren, McCluskey, Leo, Grossman, Murray, Shneider, Neil A., Chung, Wendy K., Ravits, John M., Glass, Jonathan D., Sims, Katherine B., Van Deerlin, Vivianna M., Maniatis, Tom, Hayes, Sebastian D., Ordureau, Alban, Swarup, Sharan, Landers, John, Baas, Frank, Allen, Andrew S., Bedlack, Richard S., Harper, J. Wade, Gitler, Aaron D., Rouleau, Guy A., Brown, Robert, Harms, Matthew B., Cooper, Gregory M., Harris, Tim, Myers, Richard M., Goldstein, David B.

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1443-P: Natural History of Type 1 Diabetes (T1D)—Contrasting Adult vs. Pediatric At-Risk Populations von TEMPLEMAN, ERIN, FERRAT, LAURIC A., THOMAS, NICHOLAS, SPEAKE, CATE, WHERRETT, DIANE K., SHERR, JENNIFER L., REDONDO, MARIA J., EVANS-MOLINA, CARMELLA, SOSENKO, JAY, SIMS, EMILY K., ORAM, RICHARD A.

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Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding von Bai, Hongjun, Lewitus, Eric, Li, Yifan, Thomas, Paul V., Zemil, Michelle, Merbah, Mélanie, Peterson, Caroline E., Thuraisamy, Thujitha, Rees, Phyllis A., Hajduczki, Agnes, Dussupt, Vincent, Slike, Bonnie, Mendez-Rivera, Letzibeth, Schmid, Annika, Kavusak, Erin, Rao, Mekhala, Smith, Gabriel, Frey, Jessica, Sims, Alicea, Wieczorek, Lindsay, Polonis, Victoria, Krebs, Shelly J., Ake, Julie A., Vasan, Sandhya, Bolton, Diane L., Joyce, M. Gordon, Townsley, Samantha, Rolland, Morgane

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Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention von Sims, Emily K, Geyer, Susan, Johnson, Suzanne Bennett, Libman, Ingrid, Jacobsen, Laura M, Boulware, David, Rafkin, Lisa E, Matheson, Della, Atkinson, Mark A, Rodriguez, Henry, Spall, Maria, Elding Larsson, Helena, Wherrett, Diane K, Greenbaum, Carla J, Krischer, Jeffrey, DiMeglio, Linda A

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Early Metabolic Endpoints Identify Persistent Treatment Efficacy in Recent-Onset Type 1 Diabetes Immunotherapy Trials von Jacobsen, Laura M, Cuthbertson, David, Bundy, Brian N, Atkinson, Mark A, Moore, Wayne, Haller, Michael J, Russell, William E, Gitelman, Stephen E, Herold, Kevan C, Redondo, Maria J, Sims, Emily K, Wherrett, Diane K, Moran, Antoinette, Pugliese, Alberto, Gottlieb, Peter A, Sosenko, Jay M, Ismail, Heba M

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Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes von Sims, Emily K, Bahnson, Henry T, Nyalwidhe, Julius, Haataja, Leena, Davis, Asa K, Speake, Cate, DiMeglio, Linda A, Blum, Janice, Morris, Margaret A, Mirmira, Raghavendra G, Nadler, Jerry, Mastracci, Teresa L, Marcovina, Santica, Qian, Wei-Jun, Yi, Lian, Swensen, Adam C, Yip-Schneider, Michele, Schmidt, C Max, Considine, Robert V, Arvan, Peter, Greenbaum, Carla J, Evans-Molina, Carmella

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825-P: Composite Glucose and C-Peptide Endpoints Show Early Efficacy in Recent-Onset Type 1 Diabetes (T1D) Clinical Trials von JACOBSEN, LAURA M., CUTHBERTSON, DAVID D., HALLER, MICHAEL J., ISMAIL, HEBA M., SIMS, EMILY K., GITELMAN, STEPHEN E., WHERRETT, DIANE K., MORAN, ANTOINETTE, ATKINSON, MARK A., PUGLIESE, ALBERTO, GOTTLIEB, PETER, SOSENKO, JAY

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Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer von Bishop, Ryan T., Marino, Silvia, de Ridder, Daniëlle, Allen, Richard J., Lefley, Diane V., Sims, Andrew H., Wang, Ning, Ottewell, Penelope D., Idris, Aymen I.

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Connexin43 regulates joint location in zebrafish fins von Sims, Kenneth, Eble, Diane M., Iovine, M. Kathryn

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Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche von Perry, John R. B., Ferreira, Teresa, Chasman, Daniel I., Esko, Tõnu, Thorleifsson, Gudmar, Albrecht, Eva, Ang, Wei Q., Corre, Tanguy, Cousminer, Diana L., Franceschini, Nora, Ganna, Andrea, Johnson, Andrew D., Kjellqvist, Sanela, Lunetta, Kathryn L., Porcu, Eleonora, Teumer, Alexander, Tikkanen, Emmi, Hottenga, Jouke-Jan, Pers, Tune H., Yerges-Armstrong, Laura M., Hua Zhao, Jing, Andrulis, Irene L., Anton-Culver, Hoda, Benitez, Javier, Blomqvist, Carl, Bolla, Manjeet K., Brenner, Hermann, Chang-Claude, Jenny, Chanock, Stephen, Chen, Jinhui, Chenevix-Trench, Georgia, Collée, J. Margriet, Davey Smith, George, Demerath, Ellen W., Dieffenbach, Aida K., Eriksson, Johan G., Flyger, Henrik, Franke, Lude, Gudbjartsson, Daniel F., Gudnason, Vilmundur, Guénel, Pascal, Guo, Suiqun, Hall, Per, Hartman, Catharina A., Heath, Andrew C., Hofman, Albert, Hooning, Maartje J., Hu, Frank B., Karasik, David, Kiel, Douglas P., Knight, Julia A., Kutalik, Zoltan, Lambrechts, Diether, Lindblom, Annika, Mägi, Reedik, Mannermaa, Arto, Martin, Nicholas G., Masson, Gisli, McArdle, Patrick F., Mihailov, Evelin, Nohr, Ellen A., Oostra, Ben A., Peacock, Munro, Peterlongo, Paolo, Peto, Julian, Postma, Dirkje S., Radice, Paolo, Rivadeneira, Fernando, Rose, Lynda M., Rudolph, Anja, Schlessinger, David, Sovio, Ulla, Tyrer, Jonathan, Vollenweider, Peter, Winqvist, Robert, Wolffenbuttel, Bruce H. R., Wright, Margaret J., Econs, Michael J., Loos, Ruth J. F., McCarthy, Mark I., Montgomery, Grant W., Rice, John P., Thorsteinsdottir, Unnur, van Duijn, Cornelia M., Alizadeh, Behrooz Z., Bergmann, Sven, Boerwinkle, Eric, Crisponi, Laura, Gasparini, Paolo, Gieger, Christian, Järvelin, Marjo-Riitta, Kraft, Peter, Ridker, Paul M., Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Uitterlinden, André G., Zygmunt, Marek, Murray, Anna, Ong, Ken K.

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction von Fitzgerald, Katherine A., Palsson-McDermott, Eva M., Bowie, Andrew G., Jefferies, Caroline A., Mansell, Ashley S., Brady, Gareth, Brint, Elizabeth, Dunne, Aisling, Gray, Pearl, Harte, Mary T., McMurray, Diane, Smith, Dirk E., Sims, John E., Bird, Timothy A., O'Neill, Luke A. J.

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