Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes von Augeri, David J, Robl, Jeffrey A, Betebenner, David A, Magnin, David R, Khanna, Ashish, Robertson, James G, Wang, Aiying, Simpkins, Ligaya M, Taunk, Prakash, Huang, Qi, Han, Song-Ping, Abboa-Offei, Benoni, Cap, Michael, Xin, Li, Tao, Li, Tozzo, Effie, Welzel, Gustav E, Egan, Donald M, Marcinkeviciene, Jovita, Chang, Shu Y, Biller, Scott A, Kirby, Mark S, Parker, Rex A, Hamann, Lawrence G

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Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP) von Sulsky, Richard, Magnin, David R., Huang, Yanting, Simpkins, Ligaya, Taunk, Prakash, Patel, Manorama, Zhu, Yeheng, Stouch, Terry R., Bassolino-Klimas, Donna, Parker, Rex, Harrity, Thomas, Stoffel, Robert, Taylor, David S., Lavoie, Thomas B., Kish, Kevin, Jacobson, Bruce L., Sheriff, Steven, Adam, Leonard P., Ewing, William R., Robl, Jeffrey A.

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Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors von O’Connor, Stephen P., Wang, Ying, Simpkins, Ligaya M., Brigance, Robert P., Meng, Wei, Wang, Aiying, Kirby, Mark S., Weigelt, Carolyn A., Hamann, Lawrence G.

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Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability:  Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Gro... von Magnin, David R, Robl, Jeffrey A, Sulsky, Richard B, Augeri, David J, Huang, Yanting, Simpkins, Ligaya M, Taunk, Prakash C, Betebenner, David A, Robertson, James G, Abboa-Offei, Benoni E, Wang, Aiying, Cap, Michael, Xin, Li, Tao, Li, Sitkoff, Doree F, Malley, Mary F, Gougoutas, Jack Z, Khanna, Ashish, Huang, Qi, Han, Song-Ping, Parker, Rex A, Hamann, Lawrence G

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N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation von Nirschl, Alexandra A, Zou, Yan, Krystek, Stanley R, Sutton, James C, Simpkins, Ligaya M, Lupisella, John A, Kuhns, Joyce E, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Beehler, Blake C, Grover, Gary J, Egan, Donald, Fura, Aberra, Vyas, Viral P, Li, Yi-Xin, Sack, John S, Kish, Kevin F, An, Yongmi, Bryson, James A, Gougoutas, Jack Z, DiMarco, John, Zahler, Robert, Ostrowski, Jacek, Hamann, Lawrence G

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Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors von Simpkins, Ligaya M., Bolton, Scott, Pi, Zulan, Sutton, James C., Kwon, Chet, Zhao, Guohua, Magnin, David R., Augeri, David J., Gungor, Timur, Rotella, David P., Sun, Zhong, Liu, Yajun, Slusarchyk, William S., Marcinkeviciene, Jovita, Robertson, James G., Wang, Aiying, Robl, Jeffrey A., Atwal, Karnail S., Zahler, Robert L., Parker, Rex A., Kirby, Mark S., Hamann, Lawrence G.

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Pyridine amides as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 von Wang, Haixia, Ruan, Zheming, Li, James J., Simpkins, Ligaya M., Smirk, Rebecca A., Wu, Shung C., Hutchins, Robert D., Nirschl, David S., Van Kirk, Katy, Cooper, Christopher B., Sutton, James C., Ma, Zhengping, Golla, Rajasree, Seethala, Ramakrishna, Salyan, Mary Ellen K., Nayeem, Akbar, Krystek, Stanley R., Sheriff, Steven, Camac, Daniel M., Morin, Paul E., Carpenter, Brian, Robl, Jeffrey A., Zahler, Robert, Gordon, David A., Hamann, Lawrence G.

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Dual Metalloprotease Inhibitors:  Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase von Robl, Jeffrey A, Sun, Chong-Qing, Stevenson, Jay, Ryono, Denis E, Simpkins, Ligaya M, Cimarusti, Maria P, Dejneka, Tamara, Slusarchyk, William A, Chao, Sam, Stratton, Leslie, Misra, Raj N, Bednarz, Mark S, Asaad, Magdi M, Cheung, Hong Son, Abboa-Offei, Benoni E, Smith, Patricia L, Mathers, Parker D, Fox, Maxine, Schaeffer, Thomas R, Seymour, Andrea A, Trippodo, Nick C

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A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors von Robl, Jeffrey A, Sulsky, Richard, Sun, Chong-Qing, Simpkins, Ligaya M, Wang, Tammy, Dickson, John K, Chen, Ying, Magnin, David R, Taunk, Prakash, Slusarchyk, William A, Biller, Scott A, Lan, Shih-Jung, Connolly, Fergal, Kunselman, Lori K, Sabrah, Talal, Jamil, Haris, Gordon, David, Harrity, Thomas W, Wetterau, John R

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Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors von Zhao, Guohua, Taunk, Prakash C., Magnin, David R., Simpkins, Ligaya M., Robl, Jeffrey A., Wang, Aiying, Robertson, James G., Marcinkeviciene, Jovita, Sitkoff, Doree F., Parker, Rex A., Kirby, Mark S., Hamann, Lawrence G.

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Vasopeptidase Inhibitors:  Incorporation of Geminal and Spirocyclic Substituted Azepinones in Mercaptoacyl Dipeptides von Robl, Jeffrey A, Sulsky, Richard, Sieber-McMaster, Ellen, Ryono, Denis E, Cimarusti, Maria P, Simpkins, Ligaya M, Karanewsky, Donald S, Chao, Sam, Asaad, Magdi M, Seymour, Andrea A, Fox, Maxine, Smith, Patricia L, Trippodo, Nick C

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Dual Metalloprotease Inhibitors. 6. Incorporation of Bicyclic and Substituted Monocyclic Azepinones as Dipeptide Surrogates in Angiotensin-Converting Enzyme/Neutral Endopeptidase I... von Robl, Jeffrey A, Cimarusti, Maria P, Simpkins, Ligaya M, Brown, Baerbel, Ryono, Denis E, Bird, J. Eileen, Asaad, Magdi M, Schaeffer, Thomas R, Trippodo, Nick C

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Peptidomimetic Synthesis: A Novel, Highly Stereoselective Route to Substituted Freidinger Lactams von Robl, Jeffrey A, Cimarusti, Maria P, Simpkins, Ligaya M, Weller, Harold N, Pan, Yolanda Y, Malley, Mary, DiMarco, John D

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Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) von Wang, Haixia, Robl, Jeffrey A., Hamann, Lawrence G., Simpkins, Ligaya, Golla, Rajasree, Li, Yi-Xin, Seethala, Ramakrishna, Zvyaga, Tatyana, Gordon, David A., Li, James J.

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An MTP Inhibitor that Normalizes Atherogenic Lipoprotein Levels in WHHL Rabbits von Wetterau, John R., Gregg, Richard E., Harrity, Thomas W., Arbeeny, Cynthia, Cap, Michael, Connolly, Fergal, Chu, Ching-Hsuen, George, Rocco J., Gordon, David A., Jamil, Haris, Jolibois, Kern G., Kunselman, Lori K., Lan, Shih-Jung, Maccagnan, Thomas J., Ricci, Beverly, Yan, Mujing, Young, Douglas, Chen, Ying, Fryszman, Olga M., Janette V. H. Logan, Musial, Christa L., Poss, Michael A., Robl, Jeffrey A., Simpkins, Ligaya M., Slusarchyk, William A., Sulsky, Richard, Taunk, Prakash, Magnin, David R., Tino, Joseph A., Lawrence, R. Michael, Dickson, John K., Biller, Scott A.

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N-formyl hydroxylamine containing dipeptides : Generation of a new class of vasopeptidase inhibitors von ROBL, J. A, SIMPKINS, L. M, ASAAD, M. M

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Phosphorus-containing inhibitors of HMG-CoA reductase. I. 4-[(2-Arylethyl)hydroxyphosphinyl]-3-hydroxybutanoic acids: a new class of cell selective inhibitors of cholesterol biosyn... von Karanewsky, Donald S, Badia, Michael C, Ciosek, Carl P, Robl, Jeffrey A, Sofia, Michael J, Simpkins, Ligaya M, DeLange, Barbara, Harrity, Thomas W, Biller, Scott A, Gordon, Eric M

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1-Acyltriazoles as antiinflammatory agents von Wade, Peter C, Vogt, B. Richard, Kissick, Thomas P, Simpkins, Ligaya M, Palmer, Douglas M, Millonig, Robert C

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Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 von Wang, Haixia, Ruan, Zheming, Li, James J, Simpkins, Ligaya M, Smirk, Rebecca A, Wu, Shung C, Hutchins, Robert D, Nirschl, David S, Van Kirk, Katy, Cooper, Christopher B, Sutton, James C, Ma, Zhengping, Golla, Rajasree, Seethala, Ramakrishna, Salyan, Mary Ellen K, Nayeem, Akbar, Krystek, Jr, Stanley R, Sheriff, Steven, Camac, Daniel M, Morin, Paul E, Carpenter, Brian, Robl, Jeffrey A, Zahler, Robert, Gordon, David A, Hamann, Lawrence G

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Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptides von Robl, Jeffrey A., Simpkins, Ligaya M., Stevenson, Jay, Sun, Chong-Qing, Murugesan, Natesan, Barrish, Joel C., Asaad, Magdi M., Bird, J.Eileen, Schaeffer, Thomas R., Trippodo, Nick C., Petrillo, Edward W., Karanewsky, Donald S.

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