Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds von Cruz-Migoni, Abimael, Canning, Peter, Quevedo, Camilo E., Bataille, Carole J. R., Bery, Nicolas, Miller, Ami, Russell, Angela J., Phillips, Simon E. V., Carr, Stephen B., Rabbitts, Terence H.

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Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy von Bonthron, David T, Uppal, Sandeep, Diggle, Christine P, Carr, Ian M, Fishwick, Colin W G, Ahmed, Mushtaq, Ibrahim, Gamal H, Helliwell, Philip S, Latos-Biele ska, Anna, Phillips, Simon E V, Markham, Alexander F, Bennett, Christopher P

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Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment von Quevedo, Camilo E., Cruz-Migoni, Abimael, Bery, Nicolas, Miller, Ami, Tanaka, Tomoyuki, Petch, Donna, Bataille, Carole J. R., Lee, Lydia Y. W., Fallon, Phillip S., Tulmin, Hanna, Ehebauer, Matthias T., Fernandez-Fuentes, Narcis, Russell, Angela J., Carr, Stephen B., Phillips, Simon E. V., Rabbitts, Terence H.

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Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism von Stockley, Peter G., Twarock, Reidun, Bakker, Saskia E., Barker, Amy M., Borodavka, Alexander, Dykeman, Eric, Ford, Robert J., Pearson, Arwen R., Phillips, Simon E. V., Ranson, Neil A., Tuma, Roman

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Van der Waals Interactions Dominate Ligand−Protein Association in a Protein Binding Site Occluded from Solvent Water von Barratt, Elizabeth, Bingham, Richard J, Warner, Daniel J, Laughton, Charles A, Phillips, Simon E. V, Homans, Steve W

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Reaction Mechanism of N‑Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis von Daniels, Adam D, Campeotto, Ivan, van der Kamp, Marc W, Bolt, Amanda H, Trinh, Chi H, Phillips, Simon E. V, Pearson, Arwen R, Nelson, Adam, Mulholland, Adrian J, Berry, Alan

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Rewriting nature’s assembly manual for a ssRNA virus von Patel, Nikesh, Wroblewski, Emma, Leonov, German, Phillips, Simon E. V., Tuma, Roman, Twarock, Reidun, Stockley, Peter G.

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Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging von Ptchelkine, Denis, Gillum, Ashley, Mochizuki, Tomohiro, Lucas-Staat, Soizick, Liu, Ying, Krupovic, Mart, Phillips, Simon E. V., Prangishvili, David, Huiskonen, Juha T.

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Purification, characterization, and identification of a novel bifunctional catalase-phenol oxidase from Scytalidium thermophilum von Sutay Kocabas, Didem, Bakir, Ufuk, Phillips, Simon E. V, McPherson, Michael J, Ogel, Zumrut B

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Revealing the density of encoded functions in a viral RNA von Patel, Nikesh, Dykeman, Eric C., Coutts, Robert H. A., Lomonossoff, George P., Rowlands, David J., Phillips, Simon E. V., Ranson, Neil, Twarock, Reidun, Tuma, Roman, Stockley, Peter G.

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The structural basis of Holliday junction resolution by T7 endonuclease I von HADDEN, Jonathan M, DECLAIS, Anne-Cécile, CARR, Stephen B, LILLEY, David M. J, PHILLIPS, Simon E. V

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Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase von Smith, Mark A, Pirrat, Pascale, Pearson, Arwen R, Kurtis, Christian R. P, Trinh, Chi H, Gaule, Thembaninkosi G, Knowles, Peter F, Phillips, Simon E. V, McPherson, Michael J

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Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum von Yuzugullu, Yonca, Trinh, Chi H., Smith, Mark A., Pearson, Arwen R., Phillips, Simon E. V., Sutay Kocabas, Didem, Bakir, Ufuk, Ogel, Zumrut B., McPherson, Michael J.

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Structures of replication initiation proteins from staphylococcal antibiotic resistance plasmids reveal protein asymmetry and flexibility are necessary for replication von Carr, Stephen B, Phillips, Simon E V, Thomas, Christopher D

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Importance of the Active Site “Canopy” Residues in an O2‑Tolerant [NiFe]-Hydrogenase von Brooke, Emily J, Evans, Rhiannon M, Islam, Shams T. A, Roberts, Gerri M, Wehlin, Sara A. M, Carr, Stephen B, Phillips, Simon E. V, Armstrong, Fraser A

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Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein von Bingham, Richard J., Findlay, John B. C., Hsieh, Shih-Yang, Kalverda, Arnout P., Kjellberg, Alexandra, Perazzolo, Chiara, Phillips, Simon E. V., Seshadri, Kothandaraman, Trinh, Chi H., Turnbull, W. Bruce, Bodenhausen, Geoffrey, Homans, Steve W.

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BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions von Bery, Nicolas, Cruz-Migoni, Abimael, Bataille, Carole Jr, Quevedo, Camilo E, Tulmin, Hanna, Miller, Ami, Russell, Angela, Phillips, Simon Ev, Carr, Stephen B, Rabbitts, Terence H

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Degenerate RNA Packaging Signals in the Genome of Satellite Tobacco Necrosis Virus: Implications for the Assembly of a T = 1 Capsid von Bunka, David H.J., Lane, Stephen W., Lane, Claire L., Dykeman, Eric C., Ford, Robert J., Barker, Amy M., Twarock, Reidun, Phillips, Simon E.V., Stockley, Peter G.

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The Stacking Tryptophan of Galactose Oxidase:  A Second-Coordination Sphere Residue that Has Profound Effects on Tyrosyl Radical Behavior and Enzyme Catalysis von Rogers, Melanie S, Tyler, Ejan M, Akyumani, Nana, Kurtis, Christian R, Spooner, R. Kate, Deacon, Sarah E, Tamber, Sarita, Firbank, Susan J, Mahmoud, Khaled, Knowles, Peter F, Phillips, Simon E. V, McPherson, Michael J, Dooley, David M

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2-Aminotetralones: Novel inhibitors of MurA and MurZ von Dunsmore, Colin J., Miller, Keith, Blake, Katy L., Patching, Simon G., Henderson, Peter J.F., Garnett, James A., Stubbings, William J., Phillips, Simon E.V., Palestrant, Deborah J., Angeles, Joseph De Los, Leeds, Jennifer A., Chopra, Ian, Fishwick, Colin W.G.

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