Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication von Kloss, Christopher C., Lee, Jihyun, Zhang, Aaron, Chen, Fang, Melenhorst, Jan Joseph, Lacey, Simon F., Maus, Marcela V., Fraietta, Joseph A., Zhao, Yangbing, June, Carl H.

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Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia von Mueller, Karen Thudium, Maude, Shannon L., Porter, David L., Frey, Noelle, Wood, Patricia, Han, Xia, Waldron, Edward, Chakraborty, Abhijit, Awasthi, Rakesh, Levine, Bruce L., Melenhorst, J. Joseph, Grupp, Stephan A., June, Carl H., Lacey, Simon F.

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Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies von Ruella, Marco, Barrett, David M, Kenderian, Saad S, Shestova, Olga, Hofmann, Ted J, Perazzelli, Jessica, Klichinsky, Michael, Aikawa, Vania, Nazimuddin, Farzana, Kozlowski, Miroslaw, Scholler, John, Lacey, Simon F, Melenhorst, Jan J, Morrissette, Jennifer J D, Christian, David A, Hunter, Christopher A, Kalos, Michael, Porter, David L, June, Carl H, Grupp, Stephan A, Gill, Saar

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Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas von Schuster, Stephen J, Svoboda, Jakub, Chong, Elise A, Nasta, Sunita D, Mato, Anthony R, Anak, Özlem, Brogdon, Jennifer L, Pruteanu-Malinici, Iulian, Bhoj, Vijay, Landsburg, Daniel, Wasik, Mariusz, Levine, Bruce L, Lacey, Simon F, Melenhorst, Jan J, Porter, David L, June, Carl H

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Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor von Leibman, Rachel S, Richardson, Max W, Ellebrecht, Christoph T, Maldini, Colby R, Glover, Joshua A, Secreto, Anthony J, Kulikovskaya, Irina, Lacey, Simon F, Akkina, Sarah R, Yi, Yanjie, Shaheen, Farida, Wang, Jianbin, Dufendach, Keith A, Holmes, Michael C, Collman, Ronald G, Payne, Aimee S, Riley, James L

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Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications von Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John

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PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR von Chong, Elise A., Melenhorst, J.Joseph, Lacey, Simon F., Ambrose, David E., Gonzalez, Vanessa, Levine, Bruce L., June, Carl H., Schuster, Stephen J.

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Decade-long leukaemia remissions with persistence of CD4+ CAR T cells von Melenhorst, J. Joseph, Chen, Gregory M., Wang, Meng, Porter, David L., Chen, Changya, Collins, McKensie A., Gao, Peng, Bandyopadhyay, Shovik, Sun, Hongxing, Zhao, Ziran, Lundh, Stefan, Pruteanu-Malinici, Iulian, Nobles, Christopher L., Maji, Sayantan, Frey, Noelle V., Gill, Saar I., Loren, Alison W., Tian, Lifeng, Kulikovskaya, Irina, Gupta, Minnal, Ambrose, David E., Davis, Megan M., Fraietta, Joseph A., Brogdon, Jennifer L., Young, Regina M., Chew, Anne, Levine, Bruce L., Siegel, Donald L., Alanio, Cécile, Wherry, E. John, Bushman, Frederic D., Lacey, Simon F., Tan, Kai, June, Carl H.

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B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma von Cohen, Adam D, Garfall, Alfred L, Stadtmauer, Edward A, Melenhorst, J Joseph, Lacey, Simon F, Lancaster, Eric, Vogl, Dan T, Weiss, Brendan M, Dengel, Karen, Nelson, Annemarie, Plesa, Gabriela, Chen, Fang, Davis, Megan M, Hwang, Wei-Ting, Young, Regina M, Brogdon, Jennifer L, Isaacs, Randi, Pruteanu-Malinici, Iulian, Siegel, Don L, Levine, Bruce L, June, Carl H, Milone, Michael C

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Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy von Sotillo, Elena, Barrett, David M, Black, Kathryn L, Bagashev, Asen, Oldridge, Derek, Wu, Glendon, Sussman, Robyn, Lanauze, Claudia, Ruella, Marco, Gazzara, Matthew R, Martinez, Nicole M, Harrington, Colleen T, Chung, Elaine Y, Perazzelli, Jessica, Hofmann, Ted J, Maude, Shannon L, Raman, Pichai, Barrera, Alejandro, Gill, Saar, Lacey, Simon F, Melenhorst, Jan J, Allman, David, Jacoby, Elad, Fry, Terry, Mackall, Crystal, Barash, Yoseph, Lynch, Kristen W, Maris, John M, Grupp, Stephan A, Thomas-Tikhonenko, Andrei

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CRISPR-engineered T cells in patients with refractory cancer von Stadtmauer, Edward A, Fraietta, Joseph A, Davis, Megan M, Cohen, Adam D, Weber, Kristy L, Lancaster, Eric, Mangan, Patricia A, Kulikovskaya, Irina, Gupta, Minnal, Chen, Fang, Tian, Lifeng, Gonzalez, Vanessa E, Xu, Jun, Jung, In-Young, Melenhorst, J Joseph, Plesa, Gabriela, Shea, Joanne, Matlawski, Tina, Cervini, Amanda, Gaymon, Avery L, Desjardins, Stephanie, Lamontagne, Anne, Salas-Mckee, January, Fesnak, Andrew, Siegel, Donald L, Levine, Bruce L, Jadlowsky, Julie K, Young, Regina M, Chew, Anne, Hwang, Wei-Ting, Hexner, Elizabeth O, Carreno, Beatriz M, Nobles, Christopher L, Bushman, Frederic D, Parker, Kevin R, Qi, Yanyan, Satpathy, Ansuman T, Chang, Howard Y, Zhao, Yangbing, Lacey, Simon F, June, Carl H

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Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial von Beatty, Gregory L., O’Hara, Mark H., Lacey, Simon F., Torigian, Drew A., Nazimuddin, Farzana, Chen, Fang, Kulikovskaya, Irina M., Soulen, Michael C., McGarvey, Maureen, Nelson, Anne Marie, Gladney, Whitney L., Levine, Bruce L., Melenhorst, J. Joseph, Plesa, Gabriela, June, Carl H.

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Pembrolizumab for B-cell lymphomas relapsing after or refractory to CD19-directed CAR T-cell therapy von Chong, Elise A., Alanio, Cécile, Svoboda, Jakub, Nasta, Sunita D., Landsburg, Daniel J., Lacey, Simon F., Ruella, Marco, Bhattacharyya, Siddharth, Wherry, E. John, Schuster, Stephen J.

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Neural Stem Cell-Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients von Portnow, Jana, Synold, Timothy W, Badie, Behnam, Tirughana, Revathiswari, Lacey, Simon F, D'Apuzzo, Massimo, Metz, Marianne Z, Najbauer, Joseph, Bedell, Victoria, Vo, Tien, Gutova, Margarita, Frankel, Paul, Chen, Mike, Aboody, Karen S

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PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial von Narayan, Vivek, Barber-Rotenberg, Julie S., Jung, In-Young, Lacey, Simon F., Rech, Andrew J., Davis, Megan M., Hwang, Wei-Ting, Lal, Priti, Carpenter, Erica L., Maude, Shannon L., Plesa, Gabriela, Vapiwala, Neha, Chew, Anne, Moniak, Michael, Sebro, Ronnie A., Farwell, Michael D., Marshall, Amy, Gilmore, Joan, Lledo, Lester, Dengel, Karen, Church, Sarah E., Hether, Tyler D., Xu, Jun, Gohil, Mercy, Buckingham, Thomas H., Yee, Stephanie S., Gonzalez, Vanessa E., Kulikovskaya, Irina, Chen, Fang, Tian, Lifeng, Tien, Kyle, Gladney, Whitney, Nobles, Christopher L., Raymond, Hayley E., Hexner, Elizabeth O., Siegel, Donald L., Bushman, Frederic D., June, Carl H., Fraietta, Joseph A., Haas, Naomi B.

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Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia von Maude, Shannon L, Frey, Noelle, Shaw, Pamela A, Aplenc, Richard, Barrett, David M, Bunin, Nancy J, Chew, Anne, Gonzalez, Vanessa E, Zheng, Zhaohui, Lacey, Simon F, Mahnke, Yolanda D, Melenhorst, Jan J, Rheingold, Susan R, Shen, Angela, Teachey, David T, Levine, Bruce L, June, Carl H, Porter, David L, Grupp, Stephan A

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Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia von Fitzgerald, Julie C., Weiss, Scott L., Maude, Shannon L., Barrett, David M., Lacey, Simon F., Melenhorst, J. Joseph, Shaw, Pamela, Berg, Robert A., June, Carl H., Porter, David L., Frey, Noelle V., Grupp, Stephan A., Teachey, David T.

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An NK-like CAR T cell transition in CAR T cell dysfunction von Good, Charly R., Aznar, M. Angela, Kuramitsu, Shunichiro, Samareh, Parisa, Agarwal, Sangya, Donahue, Greg, Ishiyama, Kenichi, Wellhausen, Nils, Rennels, Austin K., Ma, Yujie, Tian, Lifeng, Guedan, Sonia, Alexander, Katherine A., Zhang, Zhen, Rommel, Philipp C., Singh, Nathan, Glastad, Karl M., Richardson, Max W., Watanabe, Keisuke, Tanyi, Janos L., O’Hara, Mark H., Ruella, Marco, Lacey, Simon F., Moon, Edmund K., Schuster, Stephen J., Albelda, Steven M., Lanier, Lewis L., Young, Regina M., Berger, Shelley L., June, Carl H.

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Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells von Fraietta, Joseph A., Nobles, Christopher L., Sammons, Morgan A., Lundh, Stefan, Carty, Shannon A., Reich, Tyler J., Cogdill, Alexandria P., Morrissette, Jennifer J. D., DeNizio, Jamie E., Reddy, Shantan, Hwang, Young, Gohil, Mercy, Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Chen, Fang, Everett, John K., Alexander, Katherine A., Lin-Shiao, Enrique, Gee, Marvin H., Liu, Xiaojun, Young, Regina M., Ambrose, David, Wang, Yan, Xu, Jun, Jordan, Martha S., Marcucci, Katherine T., Levine, Bruce L., Garcia, K. Christopher, Zhao, Yangbing, Kalos, Michael, Porter, David L., Kohli, Rahul M., Lacey, Simon F., Berger, Shelley L., Bushman, Frederic D., June, Carl H., Melenhorst, J. Joseph

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First Trial of CRISPR-Edited T cells in Lung Cancer von Lacey, Simon F., Fraietta, Joseph A.

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