Trim21 deficiency in mice increases HCC carcinogenesis in a NASH context and is associated with immune checkpoint upregulation von Kara‐Ali, Ghania Hounana, Cano, Luis, Dion, Sarah, Imerzoukene, Ghiles, Hamon, Annaig, Simoes Eugénio, Mélanie, Piquet‐Pellorce, Claire, Ghukasyan, Gevorg, Samson, Michel, Le Seyec, Jacques, Dimanche‐Boitrel, Marie‐Thérèse

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Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitis von Farooq, Muhammad, Filliol, Aveline, Simoes Eugénio, Mélanie, Piquet-Pellorce, Claire, Dion, Sarah, Raguenes-Nicol, Céline, Jan, Aurélien, Dimanche-Boitrel, Marie-Thérèse, Le Seyec, Jacques, Samson, Michel

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A Transversal Approach Combining In Silico, In Vitro and In Vivo Models to Describe the Metabolism of the Receptor Interacting Protein 1 Kinase Inhibitor Sibiriline von Pelletier, Romain, Gicquel, Thomas, Simoes Eugenio, Mélanie, Ferron, Pierre-Jean, Morel, Isabelle, Delehouzé, Claire, Dimanche-Boitrel, Marie-Thérèse, Rousselot, Morgane, Le Daré, Brendan

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TRIM21, a New Component of the TRAIL-Induced Endogenous Necrosome Complex von Simoes Eugenio, Melanie, Faurez, Florence, Kara-Ali, Ghania H., Lagarrigue, Melanie, Uhart, Perrine, Bonnet, Marion C., Gallais, Isabelle, Com, Emmanuelle, Pineau, Charles, Samson, Michel, Le Seyec, Jacques, Dimanche-Boitrel, Marie-Therese

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Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor von Ahmadu, Augustine A., Delehouze, Claire, Haruna, Anas, Mustapha, Lukman, Lawal, Bilqis A., Udobre, Aniefiok, Baratte, Blandine, Triscornia, Camilla, Autret, Axelle, Robert, Thomas, Bulinski, Jeannette Chloe, Rousselot, Morgane, Eugenio, Melanie Simoes, Dimanche-Boitrel, Marie-Therese, Petzer, Jacobus P., Legoabe, Lesetja J., Bach, Stephane

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Hepatocellular Carcinoma Emergence in Diabetic Mice with Non-Alcoholic Steatohepatitis Depends on Diet and Is Delayed in Liver Exhibiting an Active Immune Response von Eugenio, Melanie Simoes, Farooq, Muhammad, Dion, Sarah, Devisme, Christelle, Raguenes-Nicol, Celine, Piquet-Pellorce, Claire, Samson, Michel, Dimanche-Boitrel, Marie-Therese, Le Seyec, Jacques

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WED-178 Enhanced liver phenotyping in unexplained chronic liver disease: the LIPHE algorithm von Sessa, Anna, Reizine, Edouard, Amaddeo, Giuliana, Simoes, Mélanie, Augustin, Jeremy, Caruso, Stefano, Calderaro, Julien, Luciani, Alain, Leroy, Vincent

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FRI-425 Hepatitis B core-related antigen (HBcrAg) in a prospective French hospital database on chronic hepatitis B (HBVbiomark) von Quang, Erwan Vo, Chevaliez, Stéphane, Giovanna, Scoazec, Anne, Varaut, Amaddeo, Giuliana, Boukraa, Amal, Simoes, Mélanie, Mazialivoua, Anne Laure, Soulier, Alexandre, Ortonne, Valérie, Garrigou, Olivia, Pawlotsky, Jean-Michel, Leroy, Vincent, Ingiliz, Patrick

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FRI-333 Sibiriline, an inhibitor of regulated necrosis, protects mice against Acetaminophen-induced liver injury, alone or in combination with N-acetyl-cysteine von Eugenio, Mélanie Simoes, Imerzoukene, Ghiles, Hamon, Annaïg, Piquet-Pellorce, Claire, Rapin, Alison, Delehouze, Claire, Belal, Sophie, Autret, Axelle, Akakpo, Jeph, Jaeschke, Hartmut, Bach, Stephane, Samson, Michel, Seyec, Jacques Le, Dimanche-Boitrel, Marie-Thérèse, Rousselot, Morgane

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Receptor-interacting protein kinase-1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms von Farooq, Muhammad, Simoes Eugénio, Mélanie, Piquet-Pellorce, Claire, Dion, Sarah, Raguenes-Nicol, Céline, Santamaria, Kathleen, Kara-Ali, Ghania Hounana, Larcher, Thibaut, Dimanche-Boitrel, Marie-Thérèse, Samson, Michel, Le Seyec, Jacques

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Hepatocyte SLAMF3 reduced specifically the multi-drugs resistance protein MRP-1 and increases HCC cells sensitization to anti-cancer drugs von Fouquet, Gregory, Debuysscher, Véronique, Ouled-Haddou, Hakim, Eugenio, Melanie Simoes, Demey, Baptiste, Singh, Amrathlal Rabbind, Ossart, Christele, Al Bagami, Mohammed, Regimbeau, Jean-Marc, Nguyen-Khac, Eric, Naassïla, Mickaël, Marcq, Ingrid, Bouhlal, Hicham

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RB/PLK1-dependent induced pathway by SLAMF3 expression inhibits mitosis and control hepatocarcinoma cell proliferation von Bouhlal, Hicham, Ouled-Haddou, Hakim, Debuysscher, Véronique, Singh, Amrathlal Rabbind, Ossart, Christèle, Reignier, Aline, Hocini, Hakim, Fouquet, Gregory, Al Baghami, Mohammed, Eugenio, Mélanie Simoes, Nguyen-Khac, Eric, Regimbeau, Jean-Marc, Marcq, Ingrid

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Socioeconomic Deprivation Weighs Heavily on Liver Fibrosis and Mortality After Hepatitis C Cure (ANRS CO22 Hepather) von Barré, Tangui, Parlati, Lucia, Bourlière, Marc, Marcellin, Fabienne, Di Beo, Vincent, Moins, Cécile, Zucman‐Rossi, Jessica, Larrey, Dominique, Carrat, Fabrice, Carrieri, Patrizia, Alric, Laurent, Payssan‐Sicart, Virginie, Pomes, Chloe, Bai, Roxane, Bailly, François, Raffi, François, Billaud, Eric, Boutoille, David, Lefebvre, Maeva, Hubert, Isabelle, Lannes, Adrien, Lunel, Françoise, Boursier, Jérôme, Giuily, Nathalie, Scoazec, Giovanna, Pol, Stanislas, Vallet‐Pichard, Anaïs, Foucher, Juliette, M’Bouyou, Jancell, Irlès‐Depé, Marie, Ahmed, Si Nafa Si, Tran, Albert, Thabut, Dominique, Moussali, Joseph, Labarrière, Damien, Nahon, Pierre, Jezequel, Caroline, Habersetzer, François, Doffoel, Michel, Simo‐Noumbissie, Pauline, Barraud, Hélène, Nani, Abdelbasset, Bernard, Marie‐Albertine, Pageaux, Georges‐Philippe, Bureau, Christophe, Morales, Thibault, Hilleret, Marie‐Noelle, Goria, Odile, Paris, Fatima, Montialoux, Hélène, Amaddeo, Giuliana, Varaut, Anne, Simoes, Mélanie, Chazouillières, Olivier, Chevance, Azeline, Serfaty, Lawrence, Coilly, Audrey, Tateo, Mariagrazia, Benjamin, Buchard, Geist, Claire, Conroy, Guillaume, Barrault, Camille, Costes, Laurent, Hagège, Hervé, Loustaud‐Ratti, Véronique, Mathurin, Philippe, Lassailly, Guillaume, Dharancy, Sébastien, Louvet, Alexandre, Latournerie, Marianne, D’Alteroche, Louis, Nicolas, Charlotte, Jaillais, Anaïs, Gournay, Jérôme, Chevalier, Caroline, Habes, Sarah, Portal, Isabelle, Saillard, Eric, Lusivika‐Nzinga, Clovis, Chane‐Teng, Jessica, Pannetier, Grégory, Sebal, Florian, Bekhti, Rafika, Boston, Anaïs, Nailler, Laura, Diallo, Alpha, Bourlière, Marc, Boursier, Jérôme, Carrat, Fabrice, Delarocque‐Astagneau, Elisabeth, Dorival, Céline, Fontaine, Hélène, Fourati, Slim, Larrey, Dominique, Petrov‐Sanchez, Ventzislava, Pol, Stanislas, Wittkop, Linda, Zoulim, Fabien, L’hennaff, Marianne, Cagnot, Carole

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Impaired health-related quality of life in the HCV cure era: who is concerned? (ANRS CO22 HEPATHER French cohort) von Carrieri, Patrizia, Bourlière, Marc, Di Beo, Vincent, Lusivika-Nzinga, Clovis, Ramier, Clémence, Antwerpes, Saskia, Protopopescu, Camelia, Lacombe, Jean-Marc, Pol, Stanislas, Fontaine, Hélène, Mourad, Abbas, Carrat, Fabrice, Duracinsky, Martin, Marcellin, Fabienne

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Hepatocyte SLAMF3 reduced specifically the multidrugs resistance protein MRP-1 and increases HCC cells sensitization to anti-cancer drugs von Fouquet, Grégory, Debuysscher, Véronique, Ouled-Haddou, Hakim, Eugenio, Mélanie Simoes, Demey, Baptiste, Singh, Amrathlal Rabbind, Ossart, Christèle, Al Bagami, Mohammed, Regimbeau, Jean-Marc, Nguyen-Khac, Eric, Naassila, Mickael, Marcq, Ingrid, Bouhlal, Hicham

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Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort von Barré, Tangui, Carrat, Fabrice, Ramier, Clémence, Fontaine, Hélène, Di Beo, Vincent, Bureau, Morgane, Dorival, Céline, Larrey, Dominique, Delarocque-Astagneau, Elisabeth, Mathurin, Philippe, Marcellin, Fabienne, Petrov-Sanchez, Ventzislava, Cagnot, Carole, Carrieri, Patrizia, Pol, Stanislas, Protopopescu, Camelia

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Receptor-interacting protein kinase-1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms von Farooq, Muhammad, Eugenio, Melanie Simoes, Piquet-Pellorce, Claire, Dion, Sarah, Raguenes-Nicol, Celine, Santamaria, Kathleen, Kara-Ali, Ghania Hounana, Larcher, Thibaut, Dimanche-Boitrel, Marie-Therese, Samson, Michel, Le Seyec, Jacques

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THE E3-UBIQUITIN LIGASE TRIM21 ACTS AS A BRAKE ON HEPATOCELLULAR CARCINOMA DEVELOPMENT IN HYPOINSULINEMIC MICE WITH NON-ALCOHOLIC STEATOHEPATITIS von Kara-Ali, Ghania, Imerzoukene, Ghiles, Eugenio, Melanie Simoes, Cano, Luis, Hamon, Annaïg, Hameed, Huma, Piquet-Pellorce, Claire, Dion, Sarah, Raguénès-Nicol, Céline, Zucman-Rossi, Jessica, Samson, Michel, Le Seyec, Jacques, Dimanche-Boitrel, Marie-Thérèse

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Mise en place et étude de modèles de progression de la NASH jusqu’au développement du CHC : effet du régime hyperlipidique sur l’environnement hépatique von Simoes Eugenio, Mélanie

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SYNERGISTIC COMBINATIONS OF REGULATED NECROSIS INHIBITORS WITH N-ACETYLCYSTEINE von DIMANCHE-BOITREL, Marie-Thérèse, ROUSSELOT, Morgane, SIMOES EUGENIO, Mélanie, BELAL, Sophie

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