The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine von Zenarruzabeitia, Olatz, Vitallé, Joana, Eguizabal, Cristina, Simhadri, Venkateswara R, Borrego, Francisco

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CD300c is uniquely expressed on CD56bright Natural Killer Cells and differs from CD300a upon ligand recognition von Dimitrova, Milena, Zenarruzabeitia, Olatz, Borrego, Francisco, Simhadri, Venkateswara R.

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Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity von Reiners, Katrin S., Topolar, Daniela, Henke, Alexander, Simhadri, Venkateswara R., Kessler, Jörg, Sauer, Maike, Bessler, Martina, Hansen, Hinrich P., Tawadros, Samir, Herling, Marco, Krönke, Martin, Hallek, Michael, Pogge von Strandmann, Elke

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Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells von Simhadri, Venkateswara R., Andersen, John F., Calvo, Eric, Choi, Seung-Chul, Coligan, John E., Borrego, Francisco

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A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells von Simhadri, Venkateswara R, Dimitrova, Milena, Mariano, John L, Zenarruzabeitia, Olatz, Zhong, Weimin, Ozawa, Tatsuhiko, Muraguchi, Atsushi, Kishi, Hiroyuki, Eichelberger, Maryna C, Borrego, Francisco

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Cutting edge: mouse CD300f (CMRF-35-like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis von Choi, Seung-Chul, Simhadri, Venkateswara R, Tian, Linjie, Gil-Krzewska, Aleksandra, Krzewski, Konrad, Borrego, Francisco, Coligan, John E

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The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adults von Zenarruzabeitia, Olatz, Vitallé, Joana, García-Obregón, Susana, Astigarraga, Itziar, Eguizabal, Cristina, Santos, Silvia, Simhadri, Venkateswara R., Borrego, Francisco

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CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection von Silva, Rodolfo, Moir, Susan, Kardava, Lela, Debell, Karen, Simhadri, Venkateswara R., Ferrando-Martínez, Sara, Leal, Manuel, Peña, José, Coligan, John E., Borrego, Francisco

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Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin von Narayanan, Sriram, Silva, Rodolfo, Peruzzi, Giovanna, Alvarez, Yelina, Simhadri, Venkateswara R, Debell, Karen, Coligan, John E, Borrego, Francisco

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Intact IL-12 signaling is necessary for the generation of human natural killer cells with enhanced effector function after restimulation von Simhadri, Venkateswara R., PhD, Mariano, John L., BS, Zenarruzabeitia, Olatz, PhD, Seroogy, Christine M., MD, Holland, Steven M., MD, Kuehn, Hye Sun, PhD, Rosenzweig, Sergio D., MD, PhD, Borrego, Francisco, MD, PhD

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CD300c is an Activating Receptor Expressed on Human Monocytes von Simhadri, Venkateswara R., Mariano, John L., Gil-Krzewska, Aleksandra, Zhou, Qing, Borrego, Francisco

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Heat Shock Protein 90 Inhibitor BIIB021 (CNF2024) Depletes NF-κB and Sensitizes Hodgkin's Lymphoma Cells for Natural Killer Cell–Mediated Cytotoxicity von BÖLL, Boris, ELTAIB, Farag, VON STRANDMANN, Elke Pogge, REINERS, Katrin S, VON TRESCKOW, Bastian, TAWADROS, Samir, SIMHADRI, Venkateswara R, BURROWS, Francis J, LUNDGREN, Karen, HANSEN, Hinrich P, ENGERT, Andreas

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A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells von Simhadri, Vijaya Lakshmi, Hansen, Hinrich P., Simhadri, Venkateswara R., Reiners, Katrin S., Bessler, Martina, Engert, Andreas, von Strandmann, Elke Pogge

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Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a von DeBell, Karen E, Simhadri, Venkateswara R, Mariano, John L, Borrego, Francisco

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Differential expression of CD300a/c on human TH1 and TH17 cells von Simhadri, Venkateswara R, Mariano, John L, Zhou, Qing, DeBell, Karen E, Borrego, Francisco

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A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo von von Strandmann, Elke Pogge, Hansen, Hinrich P., Reiners, Katrin S., Schnell, Roland, Borchmann, Peter, Merkert, Sabine, Simhadri, Venkateswara R., Draube, Andreas, Reiser, Marcel, Purr, Ingvill, Hallek, Michael, Engert, Andreas

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Intact IL-12 signaling is necessary for the generation of human NK cells with enhanced effector function after restimulation von Simhadri, Venkateswara R., Mariano, John L., Zenarruzabeitia, Olatz, Seroogy, Christine M., Holland, Steven M., Kuehn, Hye Sun, Rosenzweig, Sergio D., Borrego, Francisco

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A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity Cells von Simhadri, Venkateswara R, Dimitrova, Milena, Mariano, John L, Zenarruzabeitia, Olatz, Zhong, Weimin, Ozawa, Tatsuhiko, Muraguchi, Atsushi, Kishi, Hiroyuki, Eichelberger, Maryna C, Borrego, Francisco

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CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition von Dimitrova, Milena, Zenarruzabeitia, Olatz, Borrego, Francisco, Simhadri, Venkateswara R

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Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity von Böll, Boris, Eltaib, Farag, Reiners, Katrin S, von Tresckow, Bastian, Tawadros, Samir, Simhadri, Venkateswara R, Burrows, Francis J, Lundgren, Karen, Hansen, Hinrich P, Engert, Andreas, von Strandmann, Elke Pogge

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