Safety and efficacy of trastuzumab emtansine (TDM-1) in a patient on hemodialysis for renal failure von González, A. Falcón, Garcia, P. Estévez, Gastaldo, A. Sánchez, Simón, I. Sánchez, Boffil, J. Salvador, Borrego, M. Ruiz

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180P Immunotherapy as an effective therapy approach for advanced non-small cell lung cancer (NSCLC): A single institution experience in the context of clinical trials and expanded... von Pérez, J. Martínez, González, A. Falcón, Simón, I. Sánchez, Cervera, A., García, M. Alonso, Oncala, M.J. Flor, Jiménez, I. Gallego, Maíquez, P., Gonzàlez-Serna, L. Jiménez, Corral, J.

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Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease von Nalls, Mike A, Pankratz, Nathan, Lill, Christina M, Do, Chuong B, Hernandez, Dena G, Saad, Mohamad, DeStefano, Anita L, Kara, Eleanna, Bras, Jose, Sharma, Manu, Schulte, Claudia, Keller, Margaux F, Arepalli, Sampath, Letson, Christopher, Edsall, Connor, Stefansson, Hreinn, Liu, Xinmin, Pliner, Hannah, Lee, Joseph H, Cheng, Rong, Ikram, M Arfan, Ioannidis, John P A, Hadjigeorgiou, Georgios M, Bis, Joshua C, Martinez, Maria, Perlmutter, Joel S, Goate, Alison, Marder, Karen, Fiske, Brian, Sutherland, Margaret, Xiromerisiou, Georgia, Myers, Richard H, Clark, Lorraine N, Stefansson, Kari, Hardy, John A, Heutink, Peter, Chen, Honglei, Wood, Nicholas W, Houlden, Henry, Payami, Haydeh, Brice, Alexis, Scott, William K, Gasser, Thomas, Bertram, Lars, Eriksson, Nicholas, Foroud, Tatiana, Singleton, Andrew B

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Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease von Robak, Laurie A, Jansen, Iris E, van Rooij, Jeroen, Uitterlinden, André G, Kraaij, Robert, Jankovic, Joseph, Heutink, Peter, Shulman, Joshua M

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies von Nalls, Michael A, Plagnol, Vincent, Hernandez, Dena G, Sharma, Manu, Sheerin, Una-Marie, Saad, Mohamad, Simón-Sánchez, J, Schulte, Claudia, Lesage, Suzanne, Sveinbjörnsdóttir, Sigurlaug, Stefánsson, Kári, Martinez, Maria, Hardy, John, Heutink, Peter, Brice, Alexis, Gasser, Thomas, Singleton, Andrew B, Wood, Nicholas W

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Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets von Kia, Demis A, Zhang, David, Guelfi, Sebastian, Manzoni, Claudia, Hubbard, Leon, Reynolds, Regina H, Botía, Juan, Ryten, Mina, Ferrari, Raffaele, Lewis, Patrick A, Williams, Nigel, Trabzuni, Daniah, Hardy, John, Wood, Nicholas W

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Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome von Storm, Catherine S., Kia, Demis A., Almramhi, Mona M., Bandres-Ciga, Sara, Finan, Chris, Hingorani, Aroon D., Wood, Nicholas W.

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Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease von Beilina, Alexandria, Rudenko, Iakov N., Kaganovich, Alice, Civiero, Laura, Chau, Hien, Kalia, Suneil K., Kalia, Lorraine V., Lobbestael, Evy, Chia, Ruth, Ndukwe, Kelechi, Ding, Jinhui, Nalls, Mike A., Olszewski, Maciej, Hauser, David N., Kumaran, Ravindran, Lozano, Andres M., Baekelandt, Veerle, Greene, Lois E., Taymans, Jean-Marc, Greggio, Elisa, Cookson, Mark R.

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OA11.04 Lurbinectedin With Irinotecan in Relapsed Small Cell Lung Cancer. Results From the Expansion Stage of a Phase I-II Trial von Ponce-Aix, S., Coté, G., Falcón, A., Jimenez-Aguilar, E., Lin, J., Sánchez Simón, I., Flor, M.J., Nuñez, R., Jimenez, A.M., Jimenez, E., Extremera, S., Kahatt, C., Zeaiter, A., Paz-Ares, L.

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Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption von Cornelis, M C, Byrne, E M, Esko, T, Nalls, M A, Paynter, N, Monda, K L, Amin, N, Renstrom, F, Cavadino, A, Nolte, I M, Teumer, A, Yu, K, Manichaikul, A, Wojczynski, M K, Vink, J M, Zhao, J H, Burlutsky, G, Lahti, J, Lemaitre, R N, Eriksson, J, Musani, S K, Tanaka, T, Luan, J, Hui, J, Ho, W-K, Magnusson, P K E, Pedersen, N L, Couper, D, Oostra, B A, Tiemeier, H W, Uitterlinden, A G, Barroso, I, Xue, L, Kaakinen, M, Milani, L, Power, C, Baumeister, S E, Biffar, R, Kutalik, Z, Jacobs, D R, Lind, L, Jensen, M, Luben, R N, Wang, J J, Männistö, S, Lehtimäki, T, Viikari, J, Mozaffarian, D, Mukamal, K, Döring, A, Montgomery, G W, Dahmen, N, Tucker, K L, Ferrucci, L, Treur, J L, Mellström, D, Hottenga, J J, Tönjes, A, Deloukas, P, Kanoni, S, Lorentzon, M, Houston, D K, Liu, Y, Mason, M A, Zonderman, A B, Franke, L, Kristal, B S, Karjalainen, J, Reed, D R, Westra, H-J, Evans, M K, Dedoussis, G, Stumvoll, M, Bandinelli, S, Ordovas, J M, Chan, A T, Ohlsson, C, Gieger, C, Martin, N G, Siscovick, D S, Raitakari, O, Eriksson, J G, Mitchell, P, Hunter, D J, Rimm, E B, Borecki, I B, Vollenweider, P, Grabe, H J, Neuhouser, M L, Wolffenbuttel, B H R, Hyppönen, E, Cupples, L A, Franks, P W, van Duijn, C M, Heiss, G, Metspalu, A, North, K E, Ingelsson, E, Nettleton, J A, van Dam, R M

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471PLurbinectedin (LUR) in combination with irinotecan (IRI) in patients (pts) with advanced solid tumours von Aix, S Ponce, Flor, M J, Falcón, A, Simón, I Sánchez, Jimenez, E, Coté, G, Nuñez, R, Siguero, M, Insa, M, Cullell-Young, M, Kahatt, C, Zeaiter, A, Paz-Ares, L

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471P - Lurbinectedin (LUR) in combination with irinotecan (IRI) in patients (pts) with advanced solid tumours von Aix, S Ponce, Flor, M.J., Falcón, A., Simón, I Sánchez, Jimenez, E., Coté, G., Nuñez, R., Siguero, M., Insa, M., Cullell-Young, M., Kahatt, C., Zeaiter, A., Paz-Ares, L.

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Lurbinectedin (LUR) in combination with irinotecan (IRI) in patients (pts) with advanced solid tumours von Aix, S Ponce, Flor, M.J., Falcón, A., Simón, I Sánchez, Jimenez, E., Coté, G., Nuñez, R., Siguero, M., Insa, M., Cullell-Young, M., Kahatt, C., Zeaiter, A., Paz-Ares, L.

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Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score von Iwaki, Hirotaka, Makarious, Mary B., Bandrés‐Ciga, Sara, Leonard, Hampton L., Gibbs, J. Raphael, Singleton, Andrew B., Middlehurst, Ben, Kia, Demis A, Houlden, Henry, Morris, Huw R, Plun‐Favreau, Helene, Quinn, John, Mok, Kin Y, Kinghorn, Kerri J., Wood, Nicholas W, Lewis, Patrick, Lovering, Ruth, Rizig, Mie, Ryten, Mina, Guelfi, Sebastian, Escott‐Price, Valentina, Chelban, Viorica, Foltynie, Thomas, Williams, Nigel, Morrison, Karen E., Clarke, Carl, Brice, Alexis, Danjou, Fabrice, Lesage, Suzanne, Martinez, Maria, Simón‐Sánchez, Javier, Heutink, Peter, Rizzu, Patrizia, Sharma, Manu, Gasser, Thomas, Bandres‐Ciga, Sara, Blauwendraat, Cornelis, Craig, David W., Billingsley, Kimberley, Narendra, Derek, Raphael Gibbs, J, Shulman, Joshua M., Iwaki, Hirotaka, Leonard, Hampton L., Nalls, Mike A., Finkbeiner, Steven, Lungu, Codrin, Singleton, Andrew B, Gan‐Or, Ziv, Rouleau, Guy A., Krohn, Lynne, Aguilar, Miquel, Alvarez, Ignacio, Alvarez, Victoria, Barrero, Francisco Javier, Yarza, Jesús Alberto Bergareche, Bonilla‐Toribio, Marta, Boungiorno, María Teresa, Buiza‐Rueda, Dolores, Cámara, Ana, Carrillo, Fátima, Carrión‐Claro, Mario, Cerdan, Debora, Diez‐Fairen, Monica, Dols‐Icardo, Oriol, Duarte, Jacinto, Duran, Raquel, Escamilla‐Sevilla, Francisco, Feliz, Cici, Fernández, Manel, Gonzalez‐Aramburu, Isabel, Pagola, Ana Gorostidi, Hoenicka, Janet, Infante, Jon, Jesús, Silvia, Jimenez‐Escrig, Adriano, Kulisevsky, Jaime, Labrador‐Espinosa, Miguel A., Lopez‐Sendon, Jose Luis, Torres, Irene Martínez, Mir, Pablo, Rezola, Elisabet Mondragon, Periñán‐Tocino, Teresa, Ruiz‐Martínez, Javier, Ruz, Clara, Rodriguez, Antonio Sanchez, Tabernero, Cesar, Tartari, Juan Pablo, Tolosa, Eduard, Valldeoriola, Francesc, Vela, Lydia, Vives, Francisco, Zimprich, Alexander, Koks, Sulev, Siitonen, Ari, Kaiyrzhanov, Coordinator ‐ Rauan, Zharkinbekova, Nazira, Aitkulova, Akbota, Kaishybayeva, Gulnaz, Karimova, Altynay

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The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population‐Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight von Ahmed, Sarah, Jesús, Silvia, Méndez‐del‐Barrio, Carlota, Vargas‐González, Laura, Tartari, Juan Pablo, Mondragon, Elisabet, Vinagre‐Aragon, Ana, Dols‐Icardo, Oriol, Pascual‐Sedano, Berta, Ezquerra, Mario, Cámara, Ana, Compta, Yaroslau, Fernández, Manel, Sierra, María, Menéndez‐González, Manuel, García‐Ruiz, Pedro, Vela‐Desojo, Lydia, Barrero, Francisco Javier, Mínguez‐Castellanos, Adolfo, Cerdan, Debora, Gomez Heredia, Maria Jose, Feliz, Cici, Lopez‐Sendon, Jose Luis, Martínez Torres, Irene, Kim, Jonggeol Jeffrey, Botia, Juan A., Morrison, Karen E., Morris, Huw, Edsall, Connor, Vives, Francisco, Duran, Raquel, Hoenicka, Janet, Alvarez, Victoria, Marti, Maria José, Singleton, Andrew, Noyce, Alastair J, Holmans, Peter, Trabzuni, Daniah, Bras, Jose, Wood, Nicholas W, Guerreiro, Rita, Guelfi, Sebastian, Chelban, Viorica, Foltynie, Thomas, Morrison, Karen E., Brockmann, Kathrin, Gasser, Thomas, Cookson, Mark R, Blauwendraat, Cornelis, Craig, David W., Faghri, Faraz, Gibbs, J Raphael, Shulman, Joshua M., Leonard, Hampton L., Nalls, Mike A., Robak, Laurie, Lubbe, Steven, Mencacci, Niccolo E., Alcalay, Roy N., Krohn, Lynne, Aguilar, Miquel, Alvarez, Ignacio, Yarza, Jesús Alberto Bergareche, Blazquez, Marta, Botía, Juan A., Boungiorno, María Teresa, Buiza-Rueda, Dolores, Clarimón, Jordi, Casa, Beatríz, Diez-Fairen, Monica, Dols-Icardo, Oriol, Duarte, Jacinto, Fernández, Manel, Heredia, Maria Jose Gomez, Hoenicka, Janet, Infante, Jon, Jesús, Silvia, Jimenez-Escrig, Adriano, Arregui, Adolfo López de Munain, Marín, Juan, Mata, Marina, Mínguez, Adolfo, Mir, Pablo, Pascual-Sedano, Berta, Pastor, Pau, Errazquin, Francisco Perez, Ruiz-Martínez, Javier, Rodriguez, Antonio Sanchez, Sierra, María, Suarez-Sanmartin, Esther, Tolosa, Eduard, Valldeoriola, Francesc, Vargas-González, Laura, Zimprich, Alexander, Taba, Pille, Dalgard, Clifton L., Adeleye, Adelani, Soltis, Anthony R., Bacikova, Dagmar, Wilkerson, Matthew D.

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A two-stage meta-analysis identifies several new loci for Parkinson's disease

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Identification of sixteen novel candidate genes for late onset Parkinson's disease von Gialluisi, Alessandro, Reccia, Mafalda Giovanna, Modugno, Nicola, Nutile, Teresa, Lombardi, Alessia, Di Giovannantonio, Luca Giovanni, Pietracupa, Sara, Ruggiero, Daniela, Scala, Simona, Gambardella, Stefano, Iacoviello, Licia, Gianfrancesco, Fernando, Acampora, Dario, D'Esposito, Maurizio, Simeone, Antonio, Ciullo, Marina, Esposito, Teresa

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Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease von KELLER, Margaux F, SAAD, Mohamad, SCHULTE, Claudia, MOSKVINA, Valentina, DURR, Alexandra, HOLMANS, Peter, KILARSKI, Laura L, GUERREIRO, Rita, HERNANDEZ, Dena G, BRICE, Alexis, YLIKOTILA, Pauli, STEFANSSON, Hreinn, BRAS, Jose, MAJAMAA, Kari, MORRIS, Huw R, WILLIAMS, Nigel, GASSER, Thomas, HEUTINK, Peter, WOOD, Nicholas W, HARDY, John, MARTINEZ, Maria, SINGLETON, Andrew B, NALLS, Michael A, BETTELLA, Francesco, NICOLAOU, Nayia, SIMON-SANCHEZ, Javier, MITTAG, Florian, BÜCHEL, Finja, SHARMA, Manu, RAPHAEL GIBBS, J

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Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study von Pichler, Irene, Del Greco M, Fabiola, Gögele, Martin, Lill, Christina M, Bertram, Lars, Do, Chuong B, Eriksson, Nicholas, Foroud, Tatiana, Myers, Richard H, Nalls, Michael, Keller, Margaux F, Benyamin, Beben, Whitfield, John B, Pramstaller, Peter P, Hicks, Andrew A, Thompson, John R, Minelli, Cosetta

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NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases von Nalls, Mike A, Bras, Jose, Hernandez, Dena G, Keller, Margaux F, Majounie, Elisa, Renton, Alan E, Saad, Mohamad, Jansen, Iris, Guerreiro, Rita, Lubbe, Steven, Plagnol, Vincent, Gibbs, J. Raphael, Schulte, Claudia, Pankratz, Nathan, Sutherland, Margaret, Bertram, Lars, Lill, Christina M, DeStefano, Anita L, Faroud, Tatiana, Eriksson, Nicholas, Tung, Joyce Y, Edsall, Connor, Nichols, Noah, Brooks, Janet, Arepalli, Sampath, Pliner, Hannah, Letson, Chris, Heutink, Peter, Martinez, Maria, Gasser, Thomas, Traynor, Bryan J, Wood, Nick, Hardy, John, Singleton, Andrew B

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