PINK1/Parkin Pathway Activation for Mitochondrial Quality Control – Which Is the Best Molecular Target for Therapy? von Silvian, Laura F.

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Activation of parkin by a molecular glue von Sauvé, Véronique, Stefan, Eric, Croteau, Nathalie, Goiran, Thomas, Fakih, Rayan, Bansal, Nupur, Hadzipasic, Adelajda, Fang, Jing, Murugan, Paramasivam, Chen, Shimin, Fon, Edward A., Hirst, Warren D., Silvian, Laura F., Trempe, Jean-François, Gehring, Kalle

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ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis von Ma, Bin, Marcotte, Doug, Paramasivam, Murugan, Michelsen, Klaus, Wang, Ti, Bertolotti-Ciarlet, Andrea, Jones, John Howard, Moree, Ben, Butko, Margaret, Salafsky, Joshua, Sun, Xin, McKee, Timothy, Silvian, Laura F

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Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase von Shlevkov, Evgeny, Murugan, Paramasivam, Montagna, Dan, Stefan, Eric, Hadzipasic, Adelajda, Harvey, James S., Kumar, P. Rajesh, Entova, Sonya, Bansal, Nupur, Bickford, Shari, Wong, Lai-Yee, Hirst, Warren D., Weihofen, Andreas, Silvian, Laura F.

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Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model von Vandeveer, George H., Arduini, Robert M., Baker, Darren P., Barry, Kevin, Bohnert, Tonika, Bowden-Verhoek, Jon K., Conlon, Patrick, Cullen, Patrick F., Guan, Bing, Jenkins, Tracy J., Liao, Shu-Yu, Lin, Lin, Liu, Yu-Ting, Marcotte, Douglas, Mertsching, Elisabeth, Metrick, Claire M., Negrou, Ella, Powell, Noel, Scott, Daniel, Silvian, Laura F., Hopkins, Brian T.

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Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases von Marcotte, Douglas J., Liu, Yu‐Ting, Arduini, Robert M., Hession, Catherine A., Miatkowski, Konrad, Wildes, Craig P., Cullen, Patrick F., Hong, Victor, Hopkins, Brian T., Mertsching, Elisabeth, Jenkins, Tracy J., Romanowski, Michael J., Baker, Darren P., Silvian, Laura F.

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Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure von Marcotte, Douglas J., Hus, Jean‐Christophe, Banos, Charles C., Wildes, Craig, Arduini, Robert, Bergeron, Chris, Hession, Catherine A., Baker, Darren P., Lin, Edward, Guckian, Kevin M., Dunah, Anthone W., Silvian, Laura F.

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Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction von Lin, Edward Y. S., Silvian, Laura F., Marcotte, Douglas J., Banos, Charles C., Jow, Flora, Chan, Timothy R., Arduini, Robert M., Qian, Fang, Baker, Darren P., Bergeron, Chris, Hession, Catherine A., Huganir, Richard L., Borenstein, Cassandra F., Enyedy, Istvan, Zou, Jinming, Rohde, Ellen, Wittmann, Marion, Kumaravel, Gnanasambandam, Rhodes, Kenneth J., Scannevin, Robert H., Dunah, Anthone W., Guckian, Kevin M.

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Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand von Marcotte, Douglas J, Liu, YuTing, Little, Kevin, Jones, John H, Powell, Noel A, Wildes, Craig P, Silvian, Laura F, Chodaparambil, Jayanth V

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Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension von Marcotte, Douglas, Rushe, Mia, M. Arduini, Robert, Lukacs, Christine, Atkins, Kateri, Sun, Xin, Little, Kevin, Cullivan, Michael, Paramasivam, Murugan, Patterson, Thomas A., Hesson, Thomas, D. McKee, Timothy, May‐Dracka, Tricia L., Xin, Zhili, Bertolotti‐Ciarlet, Andrea, Bhisetti, Govinda R., Lyssikatos, Joseph P., Silvian, Laura F.

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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus von Ellenberger, Tom, Silvian, Laura F, Toth, Eric A, Pham, Phuong, Goodman, Myron F

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Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism von Silvian, Laura F, Friedman, Jessica E, Strauch, Kathy, Cachero, Teresa G, Day, Eric S, Qian, Fang, Cunningham, Brian, Fung, Amy, Sun, Lihong, Su, Lihe, Zheng, Zhongli, Kumaravel, Gnanasambandam, Whitty, Adrian

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How glutaminyl-tRNA synthetase selects glutamine von Rath, Virginia L, Silvian, Laura F, Beijer, Barbro, Sproat, Brian S, Steitz, Thomas A

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Correction to Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism von Silvian, Laura F, Friedman, Jessica E, Strauch, Kathy, Cachero, Teresa G, Day, Eric S, Qian, Fang, Cunningham, Brian, Fung, Amy, Sun, Lihong, Shipps, Gerald W, Su, Lihe, Zheng, Zhongli, Kumaravel, Gnanasambandam, Whitty, Adrian

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Insights into Editing from an Ile-tRNA Synthetase Structure with tRNA$^{Ile}$ and Mupirocin von Silvian, Laura F., Wang, Jimin, Steitz, Thomas A.

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Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension: GLK Co-crystal Structure with Aminopyrrolopyrimidine Inhibitor von Marcotte, Douglas, Rushe, Mia, M. Arduini, Robert, Lukacs, Christine, Atkins, Kateri, Sun, Xin, Little, Kevin, Cullivan, Michael, Paramasivam, Murugan, Patterson, Thomas A., Hesson, Thomas, D. McKee, Timothy, May-Dracka, Tricia L., Xin, Zhili, Bertolotti-Ciarlet, Andrea, Bhisetti, Govinda R., Lyssikatos, Joseph P., Silvian, Laura F.

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The anatomy of infidelity von Ellenberger, Tom, Silvian, Laura F

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Insights into Editing from an Ile-tRNA Synthetase Structure with [tRNA.sup.Ile] and Mupirocin von Silvian, Laura F, Wang, Jimin, Steitz, Thomas A

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Insights into Editing from an Ile-tRNA Synthetase Structure with tRNA Ile and Mupirocin von Silvian, Laura F., Wang, Jimin, Steitz, Thomas A.

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Insights into editing from an Ile-tRNA synthetase structure with tRNAIle and Mupirocin von SILVIAN, L. F, JIMIN WANG, STEITZ, T. A

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