A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection von Shapira, Sagi D., Gat-Viks, Irit, Shum, Bennett O.V., Dricot, Amelie, de Grace, Marciela M., Wu, Liguo, Gupta, Piyush B., Hao, Tong, Silver, Serena J., Root, David E., Hill, David E., Regev, Aviv, Hacohen, Nir

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Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy von Sander, Chris, Meyerson, Matthew, Singer, Samuel, Barretina, Jordi, Taylor, Barry S, Banerji, Shantanu, Ramos, Alexis H, Lagos-Quintana, Mariana, DeCarolis, Penelope L, Shah, Kinjal, Socci, Nicholas D, Weir, Barbara A, Ho, Alan, Chiang, Derek Y, Reva, Boris, Mermel, Craig H, Getz, Gad, Antipin, Yevgenyi, Beroukhim, Rameen, Major, John E, Hatton, Charles, Nicoletti, Richard, Hanna, Megan, Sharpe, Ted, Fennell, Tim J, Cibulskis, Kristian, Onofrio, Robert C, Saito, Tsuyoshi, Shukla, Neerav, Lau, Christopher, Nelander, Sven, Silver, Serena J, Sougnez, Carrie, Viale, Agnes, Winckler, Wendy, Maki, Robert G, Garraway, Levi A, Lash, Alex, Greulich, Heidi, Root, David E, Sellers, William R, Schwartz, Gary K, Antonescu, Cristina R, Lander, Eric S, Varmus, Harold E, Ladanyi, Marc

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Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells von Scholl, Claudia, Fröhling, Stefan, Dunn, Ian F., Schinzel, Anna C., Barbie, David A., Kim, So Young, Silver, Serena J., Tamayo, Pablo, Wadlow, Raymond C., Ramaswamy, Sridhar, Döhner, Konstanze, Bullinger, Lars, Sandy, Peter, Boehm, Jesse S., Root, David E., Jacks, Tyler, Hahn, William C., Gilliland, D. Gary

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Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning von Jones, Thouis R, Carpenter, Anne E, Lamprecht, Michael R, Moffat, Jason, Silver, Serena J, Grenier, Jennifer K, Castoreno, Adam B, Eggert, Ulrike S, Root, David E, Golland, Polina, Sabatini, David M

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Signaling circuitries in development: insights from the retinal determination gene network von Silver, Serena J, Rebay, Ilaria

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Proteomic and Genetic Approaches Identify Syk as an AML Target von Hahn, Cynthia K., Berchuck, Jacob E., Ross, Kenneth N., Kakoza, Rose M., Clauser, Karl, Schinzel, Anna C., Ross, Linda, Galinsky, Ilene, Davis, Tina N., Silver, Serena J., Root, David E., Stone, Richard M., DeAngelo, Daniel J., Carroll, Martin, Hahn, William C., Carr, Steven A., Golub, Todd R., Kung, Andrew L., Stegmaier, Kimberly

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Functional screening identifies miR-315 as a potent activator of Wingless signaling von Silver, Serena J, Hagen, Joshua W, Okamura, Katsutomo, Perrimon, Norbert, Lai, Eric C

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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening von McDonald, E. Robert, de Weck, Antoine, Schlabach, Michael R., Billy, Eric, Mavrakis, Konstantinos J., Hoffman, Gregory R., Belur, Dhiren, Castelletti, Deborah, Frias, Elizabeth, Gampa, Kalyani, Golji, Javad, Kao, Iris, Li, Li, Megel, Philippe, Perkins, Thomas A., Ramadan, Nadire, Ruddy, David A., Silver, Serena J., Sovath, Sosathya, Stump, Mark, Weber, Odile, Widmer, Roland, Yu, Jianjun, Yu, Kristine, Yue, Yingzi, Abramowski, Dorothee, Ackley, Elizabeth, Barrett, Rosemary, Berger, Joel, Bernard, Julie L., Billig, Rebecca, Brachmann, Saskia M., Buxton, Frank, Caothien, Roger, Caushi, Justina X., Chung, Franklin S., Cortés-Cros, Marta, deBeaumont, Rosalie S., Delaunay, Clara, Desplat, Aurore, Duong, William, Dwoske, Donald A., Eldridge, Richard S., Farsidjani, Ali, Feng, Fei, Feng, JiaJia, Flemming, Daisy, Forrester, William, Galli, Giorgio G., Gao, Zhenhai, Gauter, François, Gibaja, Veronica, Haas, Kristy, Hattenberger, Marc, Hood, Tami, Hurov, Kristen E., Jagani, Zainab, Jenal, Mathias, Johnson, Jennifer A., Jones, Michael D., Kapoor, Avnish, Korn, Joshua, Liu, Jilin, Liu, Qiumei, Liu, Shumei, Liu, Yue, Loo, Alice T., Macchi, Kaitlin J., Martin, Typhaine, McAllister, Gregory, Meyer, Amandine, Mollé, Sandra, Pagliarini, Raymond A., Phadke, Tanushree, Repko, Brian, Schouwey, Tanja, Shanahan, Frances, Shen, Qiong, Stamm, Christelle, Stephan, Christine, Stucke, Volker M., Tiedt, Ralph, Varadarajan, Malini, Venkatesan, Kavitha, Vitari, Alberto C., Wallroth, Marco, Weiler, Jan, Zhang, Jing, Mickanin, Craig, Myer, Vic E., Porter, Jeffery A., Lai, Albert, Bitter, Hans, Lees, Emma, Keen, Nicholas, Kauffmann, Audrey, Stegmeier, Frank, Hofmann, Francesco, Schmelzle, Tobias, Sellers, William R.

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The transcription factor Eyes absent is a protein tyrosine phosphatase von Rebay, Ilaria, Tootle, Tina L, Silver, Serena J, Davies, Erin L, Newman, Victoria, Latek, Robert R, Mills, Ishara A, Selengut, Jeremy D, Parlikar, Beth E. W

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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia von Knoechel, Birgit, Roderick, Justine E, Williamson, Kaylyn E, Zhu, Jiang, Lohr, Jens G, Cotton, Matthew J, Gillespie, Shawn M, Fernandez, Daniel, Ku, Manching, Wang, Hongfang, Piccioni, Federica, Silver, Serena J, Jain, Mohit, Pearson, Daniel, Kluk, Michael J, Ott, Christopher J, Shultz, Leonard D, Brehm, Michael A, Greiner, Dale L, Gutierrez, Alejandro, Stegmaier, Kimberly, Kung, Andrew L, Root, David E, Bradner, James E, Aster, Jon C, Kelliher, Michelle A, Bernstein, Bradley E

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A public genome-scale lentiviral expression library of human ORFs von Yang, Xiaoping, Boehm, Jesse S, Yang, Xinping, Salehi-Ashtiani, Kourosh, Hao, Tong, Shen, Yun, Lubonja, Rakela, Thomas, Sapana R, Alkan, Ozan, Bhimdi, Tashfeen, Green, Thomas M, Johannessen, Cory M, Silver, Serena J, Nguyen, Cindy, Murray, Ryan R, Hieronymus, Haley, Balcha, Dawit, Fan, Changyu, Lin, Chenwei, Ghamsari, Lila, Vidal, Marc, Hahn, William C, Hill, David E, Root, David E

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The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors von Marotta, Lauren L C, Almendro, Vanessa, Marusyk, Andriy, Shipitsin, Michail, Schemme, Janina, Walker, Sarah R, Bloushtain-Qimron, Noga, Kim, Jessica J, Choudhury, Sibgat A, Maruyama, Reo, Wu, Zhenhua, Gönen, Mithat, Mulvey, Laura A, Bessarabova, Marina O, Huh, Sung Jin, Silver, Serena J, Kim, So Young, Park, So Yeon, Lee, Hee Eun, Anderson, Karen S, Richardson, Andrea L, Nikolskaya, Tatiana, Nikolsky, Yuri, Liu, X Shirley, Root, David E, Hahn, William C, Frank, David A, Polyak, Kornelia

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Systematic RNA interference reveals that oncogenic KRAS -driven cancers require TBK1 von Kim, So Young, Sabatini, David M, Michel, Kathrin, Tamayo, Pablo, Weir, Barbara A, Le, Hanh, Mermel, Craig, Gupta, Piyush B, Meyerson, Matthew, Hahn, William C, Schinzel, Anna C, Hoersch, Sebastian, Lander, Eric S, Sandy, Peter, Mesirov, Jill P, Sheng, Qing, Boehm, Jesse S, Meylan, Etienne, Gilliland, D. Gary, Barbie, David A, Sos, Martin L, Fröhling, Stefan, Chan, Edmond M, Wittner, Ben S, Ramaswamy, Sridhar, Livingston, David M, Root, David E, Reiling, Jan H, Wadlow, Raymond C, Dunn, Ian F, Thomas, Roman K, Scholl, Claudia, Moody, Susan E, Silver, Serena J, Jacks, Tyler

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Functional Dissection of Eyes absent Reveals New Modes of Regulation within the Retinal Determination Gene Network von Silver, Serena J., Davies, Erin L., Doyon, Laura, Rebay, Ilaria

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CDK8 is a colorectal cancer oncogene that regulates β-catenin activity von Firestein, Ron, Bass, Adam J., Kim, So Young, Dunn, Ian F., Silver, Serena J., Guney, Isil, Freed, Ellen, Ligon, Azra H., Vena, Natalie, Ogino, Shuji, Chheda, Milan G., Tamayo, Pablo, Finn, Stephen, Shrestha, Yashaswi, Boehm, Jesse S., Jain, Supriya, Bojarski, Emeric, Mermel, Craig, Barretina, Jordi, Chan, Jennifer A., Baselga, Jose, Tabernero, Josep, Root, David E., Fuchs, Charles S., Loda, Massimo, Shivdasani, Ramesh A., Meyerson, Matthew, Hahn, William C.

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Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays von Kulkarni, Meghana M, Booker, Matthew, Silver, Serena J, Friedman, Adam, Hong, Pengyu, Perrimon, Norbert, Mathey-Prevot, Bernard

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CK1epsilon is required for breast cancers dependent on beta-catenin activity von Kim, So Young, Dunn, Ian F, Firestein, Ron, Gupta, Piyush, Wardwell, Leslie, Repich, Kara, Schinzel, Anna C, Wittner, Ben, Silver, Serena J, Root, David E, Boehm, Jesse S, Ramaswamy, Sridhar, Lander, Eric S, Hahn, William C

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Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers von Hao, Huai-Xiang, Wang, Hongyun, Liu, Chen, Kovats, Steven, Velazquez, Roberto, Lu, Hengyu, Pant, Bhavesh, Shirley, Matthew, Meyer, Matthew J, Pu, Minying, Lim, Joanne, Fleming, Michael, Alexander, LeighAnn, Farsidjani, Ali, LaMarche, Matthew J, Moody, Susan, Silver, Serena J, Caponigro, Giordano, Stuart, Darrin D, Abrams, Tinya J, Hammerman, Peter S, Williams, Juliet, Engelman, Jeffrey A, Goldoni, Silvia, Mohseni, Morvarid

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Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening von Griner, Lesley Mathews, Gampa, Kalyani, Do, Toan, Nguyen, Huyen, Farley, David, Hogan, Christopher J, Auld, Douglas S, Silver, Serena J

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CK1ε Is Required for Breast Cancers Dependent on β-Catenin Activity von Kim, So Young, Dunn, Ian F., Firestein, Ron, Gupta, Piyush, Wardwell, Leslie, Repich, Kara, Schinzel, Anna C., Wittner, Ben, Silver, Serena J., Root, David E., Boehm, Jesse S., Ramaswamy, Sridhar, Lander, Eric S., Hahn, William C.

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