HIF-1 as a target for drug development von Johnson, Randall S, Giaccia, Amato, Siim, Bronwyn G

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Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) von SIIM, Bronwyn G, LEE, Alan E, SHALAL-ZWAIN, Sahar, PRUIJN, Frederik B, MCKEAGE, Mark J, WILSON, William R

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Unsymmetrical DNA Cross-Linking Agents:  Combination of the CBI and PBD Pharmacophores von Tercel, Moana, Stribbling, Stephen M, Sheppard, Hilary, Siim, Bronwyn G, Wu, Kent, Pullen, Susan M, Botting, K. Jane, Wilson, William R, Denny, William A

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Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid von Wilson, WilliamR, Li, AlanE, Cowan, DavidS.M, Siim, BronwynG

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Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317 von SIIM, Bronwyn G, PRUIJN, Frederik B, STURMAN, Joanna R, HOGG, Alison, HAY, Michael P, BROWN, J. Martin, WILSON, William R

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Oxygen Dependence of the Metabolic Activation and Cytotoxicity of Tirapazamine: Implications for Extravascular Transport and Activity in Tumors von Hicks, Kevin O., Siim, Bronwyn G., Pruijn, Frederik B., Wilson, William R.

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Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model von Hicks, Kevin O, Fleming, Yvette, Siim, Bronwyn G, Koch, Cameron J, Wilson, William R

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Hypoxia-Selective Antitumor Agents. 16. Nitroarylmethyl Quaternary Salts as Bioreductive Prodrugs of the Alkylating Agent Mechlorethamine von Tercel, Moana, Lee, Alan E, Hogg, Alison, Anderson, Robert F, Lee, Ho H, Siim, Bronwyn G, Denny, William A, Wilson, William R

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Scintigraphic imaging of the hypoxia marker (99m)technetium-labeled 2,2'-(1,4-diaminobutane)bis(2-methyl-3-butanone) dioxime (99mTc-labeled HL-91; prognox): noninvasive detection o... von Siim, B G, Laux, W T, Rutland, M D, Palmer, B N, Wilson, W R

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Hypoxia-specific cytotoxins in cancer therapy von Brown, J. Martin, Siim, Bronwyn G.

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Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors : Relationship to tumor hypoxia von SIIM, B. G, MENKE, D. R, DORIE, M. J, BROWN, J. M

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Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs : Cytotoxicity, DNA binding, cellular uptake, and metabolism von Siim, Bronwyn G, Hicks, Kevin O, Pullen, Susan M, van Zijl, Pierre L, Denny, William A, Wilson, William R

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Adaptation of human tumor cells to tirapazamine under aerobic conditions: Implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity von Elwell, James H., Siim, Bronwyn G., Evans, James W., Brown, J.Martin

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Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro von Siim, BG, van Zijl, PL, Brown, JM

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Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5-[N, N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide (SN 23862) and the corresponding aziridine (CB 1954)... von KESTELL, Philip, PRUIJN, Frederik B, SIIM, Bronwyn G, PALMER, Brian D, WILSON, William R

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Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs von Siim, BG, Atwell, GJ, Wilson, WR

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Hypoxia-Selective Antitumor Agents. 15. Modification of Rate of Nitroreduction and Extent of Lysosomal Uptake by Polysubstitution of 4-(Alkylamino)-5-nitroquinoline Bioreductive Dr... von Siim, Bronwyn G, Atwell, Graham J, Anderson, Robert F, Wardman, Peter, Pullen, Susan M, Wilson, William R, Denny, William A

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Efficient redox cycling of nitroquinoline bioreductive drugs due to aerobic nitroreduction in Chinese hamster cells von Siim, Bronwyn G., Wilson, William R.

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Metabolic and radiolytic reduction of 4-alkylamino-5-nitroquinoline bioreductive drugs: Relationship to hypoxia-selective cytotoxicity von Siim, Bronwyn G., Atwell, Graham J., Wilson, William R.

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Does DNA targeting affect the cytotoxicity and cell uptake of basic nitroquinoline bioreductive drugs? von Slim, Bronwyn G., Denny, William A., Wilson, William R.

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