Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential von Meyer, Bjoern, Chiaravalli, Jeanne, Gellenoncourt, Stacy, Brownridge, Philip, Bryne, Dominic P., Daly, Leonard A., Grauslys, Arturas, Walter, Marius, Agou, Fabrice, Chakrabarti, Lisa A., Craik, Charles S., Eyers, Claire E., Eyers, Patrick A., Gambin, Yann, Jones, Andrew R., Sierecki, Emma, Verdin, Eric, Vignuzzi, Marco, Emmott, Edward

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MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography von Clabbers, Max T. B., Holmes, Susannah, Muusse, Timothy W., Vajjhala, Parimala R., Thygesen, Sara J., Malde, Alpeshkumar K., Hunter, Dominic J. B., Croll, Tristan I., Flueckiger, Leonie, Nanson, Jeffrey D., Rahaman, Md. Habibur, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Yoon, Chun Hong, Zhao, Jingjing, Zatsepin, Nadia A., Abbey, Brian, Sierecki, Emma, Gambin, Yann, Stacey, Katryn J., Darmanin, Connie, Kobe, Bostjan, Xu, Hongyi, Ve, Thomas

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A Novel Split Reporter Uncages New Possibilities von Sierecki, Emma

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SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species von Moustaqil, Mehdi, Ollivier, Emma, Chiu, Hsin-Ping, Van Tol, Sarah, Rudolffi-Soto, Paulina, Stevens, Christian, Bhumkar, Akshay, Hunter, Dominic J. B., Freiberg, Alexander N., Jacques, David, Lee, Benhur, Sierecki, Emma, Gambin, Yann

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PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms von Brognard, John, Sierecki, Emma, Gao, Tianyan, Newton, Alexandra C.

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Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling von Ve, Thomas, Vajjhala, Parimala R, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P, Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J, Stacey, Katryn J, Egelman, Edward H, Kobe, Bostjan

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Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor von Brooks, Andrew J., Dai, Wei, O'Mara, Megan L., Abankwa, Daniel, Chhabra, Yash, Pelekanos, Rebecca A., Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Alexandrov, Kirill, Wilson, Ian A., Doxastakis, Manolis, Mark, Alan E., Waters, Michael J.

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Single-molecule detection on a portable 3D-printed microscope von Brown, James W. P., Bauer, Arnaud, Polinkovsky, Mark E, Bhumkar, Akshay, Hunter, Dominic J. B., Gaus, Katharina, Sierecki, Emma, Gambin, Yann

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R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma von Overman, Jeroen, Fontaine, Frank, Wylie-Sears, Jill, Moustaqil, Mehdi, Huang, Lan, Meurer, Marie, Chiang, Ivy Kim, Lesieur, Emmanuelle, Patel, Jatin, Zuegg, Johannes, Pasquier, Eddy, Sierecki, Emma, Gambin, Yann, Hamdan, Mohamed, Khosrotehrani, Kiarash, Andelfinger, Gregor, Bischoff, Joyce, Francois, Mathias

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Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis von McMahon, Kerrie-Ann, Wu, Yeping, Gambin, Yann, Sierecki, Emma, Tillu, Vikas A., Hall, Thomas, Martel, Nick, Okano, Satomi, Moradi, Shayli Varasteh, Ruelcke, Jayde E., Ferguson, Charles, Yap, Alpha S., Alexandrov, Kirill, Hill, Michelle M., Parton, Robert G.

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The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 von Pang, Siew Siew, Bayly-Jones, Charles, Radjainia, Mazdak, Spicer, Bradley A., Law, Ruby H. P., Hodel, Adrian W., Parsons, Edward S., Ekkel, Susan M., Conroy, Paul J., Ramm, Georg, Venugopal, Hariprasad, Bird, Phillip I., Hoogenboom, Bart W., Voskoboinik, Ilia, Gambin, Yann, Sierecki, Emma, Dunstone, Michelle A., Whisstock, James C.

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Ultrastructural localisation of protein interactions using conditionally stable nanobodies von Ariotti, Nicholas, Rae, James, Giles, Nichole, Martel, Nick, Sierecki, Emma, Gambin, Yann, Hall, Thomas E, Parton, Robert G

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The Mediator complex and the role of protein-protein interactions in the gene regulation machinery von Sierecki, Emma

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Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae von Gambin, Yann, Ariotti, Nicholas, McMahon, Kerrie-Ann, Bastiani, Michele, Sierecki, Emma, Kovtun, Oleksiy, Polinkovsky, Mark E, Magenau, Astrid, Jung, Wooram, Okano, Satomi, Zhou, Yong, Leneva, Natalya, Mureev, Sergey, Johnston, Wayne, Gaus, Katharina, Hancock, John F, Collins, Brett M, Alexandrov, Kirill, Parton, Robert G

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Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death von Steain, Megan, Baker, Max O. D. G, Pham, Chi L. L, Shanmugam, Nirukshan, Gambin, Yann, Sierecki, Emma, McSharry, Brian P, Avdic, Selmir, Slobedman, Barry, Sunde, Margaret, Abendroth, Allison, Gao, Shou-Jiang, Mocarski, Edward

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Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice von Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A B, Holmes, Kelly, Salim, Angela A, Mamidyala, Sreeman, Butler, Mark S, Robinson, Ashley S, Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L, Hogan, Benjamin M, De Val, Sarah, Capon, Robert J, Carroll, Jason S, Bailey, Timothy L, Koopman, Peter, Jauch, Ralf, Cooper, Matthew A, Gambin, Yann, Francois, Mathias

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Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein von Leitão, André D. G., Rudolffi-Soto, Paulina, Chappard, Alexandre, Bhumkar, Akshay, Lau, Derrick, Hunter, Dominic J. B., Gambin, Yann, Sierecki, Emma

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Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice von Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A B, Holmes, Kelly, Salim, Angela A, Mamidyala, Sreeman, Butler, Mark S, Robinson, Ashley S, Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L, Hogan, Benjamin M, De Val, Sarah, Capon, Robert J, Carroll, Jason S, Bailey, Timothy L, Koopman, Peter, Jauch, Ralf, Cooper, Matthew A, Gambin, Yann, Francois, Mathias

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The RHIM of the Immune Adaptor Protein TRIF Forms Hybrid Amyloids with Other Necroptosis-Associated Proteins von Baker, Max O D G, Shanmugam, Nirukshan, Pham, Chi L L, Ball, Sarah R, Sierecki, Emma, Gambin, Yann, Steain, Megan, Sunde, Margaret

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Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response von McMahon, Kerrie-Ann, Stroud, David A, Gambin, Yann, Tillu, Vikas, Bastiani, Michele, Sierecki, Emma, Polinkovsky, Mark E, Hall, Thomas E, Gomez, Guillermo A, Wu, Yeping, Parat, Marie-Odile, Martel, Nick, Lo, Harriet P, Khanna, Kum Kum, Alexandrov, Kirill, Daly, Roger, Yap, Alpha, Ryan, Michael T, Parton, Robert G

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