A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization von Arras, Paul, Yoo, Han Byul, Pekar, Lukas, Schröter, Christian, Clarke, Thomas, Krah, Simon, Klewinghaus, Daniel, Siegmund, Vanessa, Evers, Andreas, Zielonka, Stefan

Volltext

A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody-Drug Conjugates von Barron, Nadine, Dickgiesser, Stephan, Fleischer, Markus, Bachmann, Angelika-Nicole, Klewinghaus, Daniel, Hannewald, Jens, Ciesielski, Elke, Kusters, Ilja, Hammann, Til, Krause, Volker, Fuchs, Sebastian Winfried, Siegmund, Vanessa, Gross, Alec W, Mueller-Pompalla, Dirk, Krah, Simon, Zielonka, Stefan, Doerner, Achim

Volltext

Cattle-derived knob paratopes grafted onto peripheral loops of the IgG1 Fc region enable the generation of a novel symmetric bispecific antibody format von Yanakieva, Desislava, Vollmer, Lena, Evers, Andreas, Siegmund, Vanessa, Arras, Paul, Pekar, Lukas, Doerner, Achim, Valldorf, Bernhard, Kolmar, Harald, Zielonka, Stefan, Krah, Simon

Volltext

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition von Lipinski, Britta, Unmuth, Laura, Arras, Paul, Becker, Stefan, Bauer, Christina, Toleikis, Lars, Krah, Simon, Doerner, Achim, Yanakieva, Desislava, Boje, Ammelie Svea, Klausz, Katja, Peipp, Matthias, Siegmund, Vanessa, Evers, Andreas, Kolmar, Harald, Pekar, Lukas, Zielonka, Stefan

Volltext

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a pr... von Arras, Paul, Yoo, Han Byul, Pekar, Lukas, Clarke, Thomas, Friedrich, Lukas, Schröter, Christian, Schanz, Jennifer, Tonillo, Jason, Siegmund, Vanessa, Doerner, Achim, Krah, Simon, Guarnera, Enrico, Zielonka, Stefan, Evers, Andreas

Volltext

The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates von Santner, Tobias, Siegmund, Vanessa, Marx, Andreas, Micura, Ronald

Volltext

Enzymatic synthesis of 2′-methylseleno-modified RNA von Siegmund, Vanessa, Santner, Tobias, Micura, Ronald, Marx, Andreas

Volltext

Systematic mutational analysis reveals an essential role of N275 in IgE stability von Kumari, Shikha, Ghosh, Sanjay, Joshi, Saurabh, Guenther, Ralf, Siegmund, Vanessa, Doerner, Achim

Volltext

NKp46‐specific single domain antibodies enable facile engineering of various potent NK cell engager formats von Lipinski, Britta, Arras, Paul, Pekar, Lukas, Klewinghaus, Daniel, Boje, Ammelie Svea, Krah, Simon, Zimmermann, Jasmin, Klausz, Katja, Peipp, Matthias, Siegmund, Vanessa, Evers, Andreas, Zielonka, Stefan

Volltext

SpyLigase-Catalyzed Modification of Antibodies von Siegmund, Vanessa, Piater, Birgit, Fischer, Frank, Kolmar, Harald

Volltext

Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features... von Arras, Paul, Zimmermann, Jasmin, Lipinski, Britta, Valldorf, Bernhard, Evers, Andreas, Elter, Desislava, Krah, Simon, Doerner, Achim, Guarnera, Enrico, Siegmund, Vanessa, Kolmar, Harald, Pekar, Lukas, Zielonka, Stefan

Volltext

Screening mutant libraries of T7 RNA polymerase for candidates with increased acceptance of 2'-modified nucleotides von Siegmund, Vanessa, Santner, Tobias, Micura, Ronald, Marx, Andreas

Volltext

Enzymatic synthesis of 8-vinyl- and 8-styryl-2′-deoxyguanosine modified DNA—novel fluorescent molecular probes von Holzberger, Bastian, Strohmeier, Julian, Siegmund, Vanessa, Diederichsen, Ulf, Marx, Andreas

Volltext

Spontaneous Isopeptide Bond Formation as a Powerful Tool for Engineering Site-Specific Antibody-Drug Conjugates von Siegmund, Vanessa, Piater, Birgit, Zakeri, Bijan, Eichhorn, Thomas, Fischer, Frank, Deutsch, Carl, Becker, Stefan, Toleikis, Lars, Hock, Björn, Betz, Ulrich A. K., Kolmar, Harald

Volltext

Locked by Design: A Conformationally Constrained Transglutaminase Tag Enables Efficient Site-Specific Conjugation von Siegmund, Vanessa, Schmelz, Stefan, Dickgiesser, Stephan, Beck, Jan, Ebenig, Aileen, Fittler, Heiko, Frauendorf, Holm, Piater, Birgit, Betz, Ulrich A. K., Avrutina, Olga, Scrima, Andrea, Fuchsbauer, Hans-Lothar, Kolmar, Harald

Volltext

Screening mutant libraries of T7 RNA polymerase for candidates with increased acceptance of 2-modified nucleotidesElectronic supplementary information (ESI) available. See DOI: 10.... von Siegmund, Vanessa, Santner, Tobias, Micura, Ronald, Marx, Andreas

Volltext

Solution Structure and Conformational Dynamics of Deoxyxylonucleic Acids (dXNA): An Orthogonal Nucleic Acid Candidate von Maiti, Mohitosh, Siegmund, Vanessa, Abramov, Mikhail, Lescrinier, Eveline, Rosemeyer, Helmut, Froeyen, Mathy, Ramaswamy, Amutha, Ceulemans, Arnout, Marx, Andreas, Herdewijn, Piet

Volltext

Solution structure and conformational dynamics of deoxyxylonucleic acids (dXNA): An orthogonal nucleic acid candidate von Maiti, Mohitosh, Siegmund, Vanessa, Abramov, Mikhail, Lescrinier, Eveline, Rosemeyer, Helmut, Froeyen, Mathy, Ramaswamy, Amutha, Ceulemans, Arnout, Marx, Andreas, Herdewijn, Piet

Volltext

Durch Design verbrückt: ein konformativ eingeschränkter Transglutaminase‐Marker ermöglicht effiziente ortsspezifische Konjugation von Siegmund, Vanessa, Schmelz, Stefan, Dickgiesser, Stephan, Beck, Jan, Ebenig, Aileen, Fittler, Heiko, Frauendorf, Holm, Piater, Birgit, Betz, Ulrich A. K., Avrutina, Olga, Scrima, Andrea, Fuchsbauer, Hans‐Lothar, Kolmar, Harald

Volltext

A transglutamine tag for efficient site-specific bioconjugation von PIATER Birgit, BETZ Ulrich, KOLMAR Harald, SIEGMUND Vanessa

Volltext bestellen