The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression von Niknafs, Yashar S., Han, Sumin, Ma, Teng, Speers, Corey, Zhang, Chao, Wilder-Romans, Kari, Iyer, Matthew K., Pitchiaya, Sethuramasundaram, Malik, Rohit, Hosono, Yasuyuki, Prensner, John R., Poliakov, Anton, Singhal, Udit, Xiao, Lanbo, Kregel, Steven, Siebenaler, Ronald F., Zhao, Shuang G., Uhl, Michael, Gawronski, Alexander, Hayes, Daniel F., Pierce, Lori J., Cao, Xuhong, Collins, Colin, Backofen, Rolf, Sahinalp, Cenk S., Rae, James M., Chinnaiyan, Arul M., Feng, Felix Y.

Volltext

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development von Shankar, Sunita, Tien, Jean Ching-Yi, Siebenaler, Ronald F., Chugh, Seema, Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Wang, Xiao-Ming, Apel, Ingrid J., Waninger, Jessica, Eyunni, Sanjana, Xu, Alice, Mody, Malay, Goodrum, Andrew, Zhang, Yuping, Tesmer, John J., Mannan, Rahul, Cao, Xuhong, Vats, Pankaj, Pitchiaya, Sethuramasundaram, Ellison, Stephanie J., Shi, Jiaqi, Kumar-Sinha, Chandan, Crawford, Howard C., Chinnaiyan, Arul M.

Volltext

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias von Zorko, Nicholas A., Bernot, Kelsie M., Whitman, Susan P., Siebenaler, Ronald F., Ahmed, Elshafa H., Marcucci, Gabriele G., Yanes, Daniel A., McConnell, Kathleen K., Mao, Charlene, Kalu, Chidimma, Zhang, Xiaoli, Jarjoura, David, Dorrance, Adrienne M., Heerema, Nyla A., Lee, Benjamin H., Huang, Gang, Marcucci, Guido, Caligiuri, Michael A.

Volltext

Biochemical characterization of the interaction between KRAS and Argonaute 2 von Waninger, Jessica J., Beyett, Tyler S., Gadkari, Varun V., Siebenaler, Ronald F., Kenum, Carson, Shankar, Sunita, Ruotolo, Brandon T., Chinnaiyan, Arul M., Tesmer, John J.G.

Volltext

Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease von Bernot, Kelsie M, Nemer, John S, Santhanam, Ramasamy, Liu, Shujun, Zorko, Nicholas A, Whitman, Susan P, Dickerson, Kathryn E, Zhang, Mengzi, Yang, Xiaojuan, McConnell, Kathleen K, Ahmed, Elshafa H, Muñoz, Maura R, Siebenaler, Ronald F, Marcucci, Gabriel G, Mundy-Bosse, Bethany L, Brook, Daniel L, Garman, Sabrina, Dorrance, Adrienne M, Zhang, Xiaoli, Zhang, Jianying, Lee, Robert J, Blum, William, Caligiuri, Michael A, Marcucci, Guido

Volltext

Argonaute 2 modulates EGFR-RAS signaling to promote mutant HRAS and NRAS- driven malignancies von Siebenaler, Ronald F, Chugh, Seema, Waninger, Jessica J, Dommeti, Vijaya L, Kenum, Carson, Mody, Malay, Gautam, Anudeeta, Patel, Nidhi, Chu, Alec, Bawa, Pushpinder, Hon, Jennifer, Smith, Richard D, Carlson, Heather, Cao, Xuhong, Tesmer, John J G, Shankar, Sunita, Chinnaiyan, Arul M

Volltext

Structural Characterization of KRAS with a Novel Interactor, Argonaute 2 von Waninger, Jessica, Shankar, Sunita, Siebenaler, Ronald F., Beyett, Tyler S., Tesmer, John J., Chinnaiyan, Arul M.

Volltext

Abstract 1362: Argonaute 2 controls RAS activation in mouse embryonic fibroblasts von Siebenaler, Ronald F., Shankar, Sunita, Dommeti, Vijaya L., Mody, Malay, Chinnaiyan, Arul

Volltext

Abstract 4370: Regulation of AGO2-KRAS interaction through epidermal growth factor receptor von Siebenaler, Ronald F., Shankar, Sunita, Tien, Jean C., Dommeti, Vijaya L., Mody, Malay, Kumar-Sinha, Chandan, Chinnaiyan, Arul M.

Volltext

Abstract A21: Loss of Argonaute 2 leads to oncogene-induced senescence in mutant RAS-driven cancer von Siebenaler, Ronald F., Shankar, Sunita, Tien, Jean C., Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Waninger, Jessica, Mody, Malay, Chugh, Seema, Kumar-Sinha, Chandan, Chinnaiyan, Arul M.

Volltext

Abstract 94: Role of Argonaute 2 in oncogene induced senescence in a pancreatic cancer mouse model von Chugh, Seema, Tien, Jean C., Siebenaler, Ronald F., Dommeti, Vijaya L., Wang, Sylvia Z., Eyunni, Sanjana, Juckette, Kristin M., Wang, Lisha, Shankar, Sunita, Chinnaiyan, Arul M.

Volltext

Abstract 2578: An essential role for Argonaute 2 in HRAS and NRAS driven oncogenesis von Siebenaler, Ronald F., Waninger, Jessica, Shankar, Sunita, Chugh, Seema, Chu, Shih-Chun, Tien, Jean, Dommeti, Vijaya L., Mody, Malay, Gautam, Anudeeta, Kenum, Carson, Kumar-Sinha, Chandan, Chinnaiyan, Arul M.

Volltext

Abstract 956: An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development von Siebenaler, Ronald F., Shankar, Sunita, Tien, Jean C., Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Chugh, Seema, Apel, Ingrid J., Mody, Malay, Gautam, Anudeeta, Kumar-Sinha, Chandan, Chinnaiyan, Arul M.

Volltext

Abstract 2577: AGO2 interaction limits wild type RAS activation yet essential for disease progression in oncogenic KRAS driven cancers von Shankar, Sunita, Tien, Jean Ching-Yi, Siebenaler, Ronald F., Chugh, Seema, Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Waninger, Jessica, Juckette, Kristin M., Wang, Xiao-Ming, Eyunni, Sanjana, Goodrum, Andrew, Zhang, Yuping, Apel, Ingrid J., Siddiqui, Javed, Cao, Xuhong, Shi, Jiaqi, Pitchiaya, Sethuramsundaram, Kumar-Sinha, Chandan, Crawford, Howard C., Chinnaiyan, Arul M.

Volltext

Abstract 3020: An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development von Shankar, Sunita, Tien, Jean, Siebenaler, Ronald F., Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Juckette, Kristin M., Xu, Alice, Mody, Malay, Goodrum, Andrew, Tsaloff, Grace, Apel, Ingrid J., Wang, Lisha, Siddiqui, Javed, Shi, Jiaqi, Kumar-Sinha, Chandan, Chinnaiyan, Arul

Volltext

Abstract A20: An essential role for Argonaute 2 in mouse models of KRAS driven cancers von Shankar, Sunita, Tien, Jean Ching-Yi, Siebenaler, Ronald F., Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Waninger, Jessica, Wang, Xiao-Ming, Juckette, Kristin M., Xu, Alice, Chugh, Seema, Mody, Malay, Eyunni, Sanjana, Goodrum, Andrew, Tsaloff, Grace, Zhang, Yuping, Apel, Ingrid J., Wang, Lisha, Siddiqui, Javed, Smith, Richard D., Carlson, Heather A., Tesmer, John, Cao, Xuhong, Shi, Jiaqi, Kumar-Sinha, Chandan, Chinnaiyan, Arul M.

Volltext

Abstract 957: An essential role for Argonaute 2 in mouse models of KRAS- driven cancers von Shankar, Sunita, Tien, Jean Ching-Yi, Siebenaler, Ronald F., Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Waninger, Jessica, Juckette, Kristin M., Xu, Alice, Wang, Xiao-Ming, Chugh, Seema, Mody, Malay, Eyunni, Sanjana, Goodrum, Andrew, Tsaloff, Grace, Zhang, Yuping, Apel, Ingrid J., Siddiqui, Javed, Smith, Richard D., Carlson, Heather A., Tesmer, John, Cao, Xuhong, Shi, Jiaqi, Kumar-Sinha, Chandan, Chinnaiyan, Arul M.

Volltext

Abstract 3849: The partial tandem duplication of Mll (Mll PTD) is a gain-of-function in the absence of Mll wildtype (Mll WT) in adult mouse hematopoiesis von Zorko, Nicholas A., Yanes, Daniel A., Lewis, W. Courtland, Brook, Daniel L., Bernot, Kelsie M., Siebenaler, Ronald F., Whitman, Susan P., Ahmed, Elshafa H., McConnell, Kathleen K., Nemer, John, Ernst, Patricia, Huang, Gang, Marcucci, Guido, Caligiuri, Michael A.

Volltext

Eradicating acute myeloid leukemia in a MllPTD/wt:Flt3ITD/wt murine model: a path to novel therapeutic approaches for human disease von Bernot, Kelsie M., Nemer, John S., Santhanam, Ramasamy, Liu, Shujun, Zorko, Nicholas A., Whitman, Susan P., Dickerson, Kathryn E., Zhang, Mengzi, Yang, Xiaojuan, McConnell, Kathleen K., Ahmed, Elshafa H., Muñoz, Maura R., Siebenaler, Ronald F., Marcucci, Gabriel G., Mundy-Bosse, Bethany L., Brook, Daniel L., Garman, Sabrina, Dorrance, Adrienne M., Zhang, Xiaoli, Zhang, Jianying, Lee, Robert J., Blum, William, Caligiuri, Michael A., Marcucci, Guido

Volltext

Abstract 3249: Targeting the miR29b/Sp1/Dnmt pathway for curative therapy in Mll-PTD/Flt3-ITD acute myeloid leukemia von Bernot, Kelsie M., Nemer, John S., Santhanam, Ramasamy, Liu, Shujun, Marcucci, Gabriel G., Zorko, Nicholas A., Whitman, Susan P., Yan, Pearlly, Frankhouser, David, Bundschuh, Ralf, Zhang, Mengzi, Siebenaler, Ronald F., Ahmed, Elshafa H., McConnell, Kathleen K., Munoz, Maura, Brook, Daniel L., Dorrance, Adrienne M., Dickerson, Katy E., Zhang, Xiaoli, Zhang, Jianying, Jarjoura, David, Lee, Robert, Blum, William, Caligiuri, Michael A., Marcucci, Guido

Volltext