Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition von Hata, Aaron N, Niederst, Matthew J, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Mulvey, Hillary E, Maruvka, Yosef E, Ji, Fei, Bhang, Hyo-eun C, Krishnamurthy Radhakrishna, Viveksagar, Siravegna, Giulia, Hu, Haichuan, Raoof, Sana, Lockerman, Elizabeth, Kalsy, Anuj, Lee, Dana, Keating, Celina L, Ruddy, David A, Damon, Leah J, Crystal, Adam S, Costa, Carlotta, Piotrowska, Zofia, Bardelli, Alberto, Iafrate, Anthony J, Sadreyev, Ruslan I, Stegmeier, Frank, Getz, Gad, Sequist, Lecia V, Faber, Anthony C, Engelman, Jeffrey A

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Therapy-induced APOBEC3A drives evolution of persistent cancer cells von Isozaki, Hideko, Sakhtemani, Ramin, Abbasi, Ammal, Nikpour, Naveed, Stanzione, Marcello, Oh, Sunwoo, Langenbucher, Adam, Monroe, Susanna, Su, Wenjia, Cabanos, Heidie Frisco, Siddiqui, Faria M., Phan, Nicole, Jalili, Pégah, Timonina, Daria, Bilton, Samantha, Gomez-Caraballo, Maria, Archibald, Hannah L., Nangia, Varuna, Dionne, Kristin, Riley, Amanda, Lawlor, Matthew, Banwait, Mandeep Kaur, Cobb, Rosemary G., Zou, Lee, Dyson, Nicholas J., Ott, Christopher J., Benes, Cyril, Getz, Gad, Chan, Chang S., Shaw, Alice T., Gainor, Justin F., Lin, Jessica J., Sequist, Lecia V., Piotrowska, Zofia, Yeap, Beow Y., Engelman, Jeffrey A., Lee, Jake June-Koo, Maruvka, Yosef E., Buisson, Rémi, Lawrence, Michael S., Hata, Aaron N.

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Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS -Mutant Non-Small Cell Lung Cancer von Nangia, Varuna, Siddiqui, Faria M, Caenepeel, Sean, Timonina, Daria, Bilton, Samantha J, Phan, Nicole, Gomez-Caraballo, Maria, Archibald, Hannah L, Li, Chendi, Fraser, Cameron, Rigas, Diamanda, Vajda, Kristof, Ferris, Lorin A, Lanuti, Michael, Wright, Cameron D, Raskin, Kevin A, Cahill, Daniel P, Shin, John H, Keyes, Colleen, Sequist, Lecia V, Piotrowska, Zofia, Farago, Anna F, Azzoli, Christopher G, Gainor, Justin F, Sarosiek, Kristopher A, Brown, Sean P, Coxon, Angela, Benes, Cyril H, Hughes, Paul E, Hata, Aaron N

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Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila von Kroll, Jason R, Wong, Karen G, Siddiqui, Faria M, Tanouye, Mark A

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Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers von Hata, A N, Rowley, S, Archibald, H L, Gomez-Caraballo, M, Siddiqui, F M, Ji, F, Jung, J, Light, M, Lee, J S, Debussche, L, Sidhu, S, Sadreyev, R I, Watters, J, Engelman, J A

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Abstract 2163: Combined targeting of MEK and MCL-1 induces apoptosis and tumor regression of KRAS mutant NSCLC von Hata, Aaron N., Siddiqui, Faria M., Gomez-Caraballo, Maria, Bilton, Samantha J., Timonina, Daria, Nangia, Varuna, Coxon, Angela, Caenepeel, Sean, Hughes, Paul

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Exploiting MCL-1 dependency with combination MEK + MCL-1 inhibitors leads to induction of apoptosis and tumor regression in KRAS mutant non-small cell lung cancer von Nangia, Varuna, Siddiqui, Faria M., Caenepeel, Sean, Timonina, Daria, Bilton, Samantha J., Phan, Nicole, Gomez-Caraballo, Maria, Archibald, Hannah L., Li, Chendi, Fraser, Cameron, Rigas, Diamanda, Vajda, Kristof, Ferris, Lorin A., Lanuti, Michael, Wright, Cameron D., Raskin, Kevin A., Cahill, Daniel P., Shin, John H., Keyes, Colleen, Sequist, Lecia V., Piotrowska, Zofia, Farago, Anna F., Azzoli, Christopher G., Gainor, Justin F., Sarosiek, Kristopher A., Brown, Sean P., Coxon, Angela, Benes, Cyril H., Hughes, Paul E., Hata, Aaron N.

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Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition von Hata, Aaron N, Niederst, Matthew J, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Mulvey, Hillary E, Maruvka, Yosef E, Ji, Fei, Bhang, Hyo-eun C, Radhakrishna, Viveksagar Krishnamurthy, Siravegna, Giulia, Hu, Haichuan, Raoof, Sana, Lockerman, Elizabeth, Kalsy, Anuj, Lee, Dana, Keating, Celina L, Ruddy, David A, Damon, Leah J, Crystal, Adam S, Costa, Carlotta, Piotrowska, Zofia, Bardelli, Alberto, Iafrate, Anthony J, Sadreyev, Ruslan I, Stegmeier, Frank, Getz, Gad, Sequist, Lecia V, Faber, Anthony C, Engelman, Jeffrey A

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Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers von Hata, Aaron N, Rowley, Steve, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Ji, Fei, Jung, Joonil, Light, Madelyn, Lee, Joon Sang, Debussche, Laurent, Sidhu, Sukhvinder, Sadreyev, Ruslan I, Watters, James, Engelman, Jeffrey A

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