Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection von Peritore-Galve, F Christopher, Shupe, John A, Cave, Rory J, Childress, Kevin O, Washington, M Kay, Kuehne, Sarah A, Lacy, D Borden

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Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile inf... von Nabukhotna, Kateryna, Kordus, Shannon L, Shupe, John A, Cano Rodríguez, Rubén, Smith, Anna, Bohannon, Julia K, Washington, M Kay, Lacy, D Borden

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Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo von Kordus, Shannon L, Kroh, Heather K, Rodríguez, Rubén Cano, Shrem, Rebecca A, Peritore-Galve, F Christopher, Shupe, John A, Wadzinski, Brian E, Lacy, D Borden, Spiller, Benjamin W

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Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection von Peritore-Galve, F. Christopher, Kaji, Izumi, Smith, Anna, Walker, Lauren M., Shupe, John A., Washington, M. Kay, Algood, Holly M. Scott, Dudeja, Pradeep K., Goldenring, James R., Lacy, D. Borden

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Cecum axis (CecAx) preservation reveals physiological and pathological gradients in mouse gastrointestinal epithelium von Lunnemann, Hannah M, Shealy, Nicolas G, Reyzer, Michelle L, Shupe, John A, Green, Emily H, Siddiqi, Uswah, Lacy, D Borden, Byndloss, Mariana X, Markham, Nicholas O

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Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease von Mileto, Steven J., Jardé, Thierry, Childress, Kevin O., Jensen, Jaime L., Rogers, Ashleigh P., Kerr, Genevieve, Hutton, Melanie L., Sheedlo, Michael J., Bloch, Sarah C., Shupe, John A., Horvay, Katja, Flores, Tracey, Engel, Rebekah, Wilkins, Simon, McMurrick, Paul J., Lacy, D. Borden, Abud, Helen E., Lyras, Dena

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Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host von Wexler, Aaron G., Guiberson, Emma R., Beavers, William N., Shupe, John A., Washington, M. Kay, Lacy, D. Borden, Caprioli, Richard M., Spraggins, Jeffrey M., Skaar, Eric P.

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Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis von Markham, Nicholas O., Bloch, Sarah C., Shupe, John A., Laubacher, Erin N., Thomas, Audrey K., Kroh, Heather K., Childress, Kevin O., Peritore-Galve, F. Christopher, Washington, M. Kay, Coffey, Robert J., Lacy, D. Borden

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Sa1228 DELETED IN MALIGNANT BRAIN TUMORS 1 (DMBT1) GLYCOPROTEIN IS LOST IN EARLY COLONIC DYSPLASIA von Green, Emily H., Lunnemann, Hannah, Rutherford, Megan, Shupe, John A., Coffey, Robert J., Lacy, Dana B., Markham, Nicholas O.

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Sa1218 CECUM AXIS (CECAX) PRESERVATION REVEALS PHYSIOLOGICAL AND PATHOLOGICAL GRADIENTS IN MOUSE GASTROINTESTINAL EPITHELIUM von Lunnemann, Hannah, Shealy, Nicolas, Reyzer, Michelle, Shupe, John A., Green, Emily H., Siddiqi, Uswah, Lacy, Dana B., Byndloss, Mariana, Markham, Nicholas O.

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Sa1138 MURINE INTRARECTAL INSTILLATION OF PURIFIED RECOMBINANT C. DIFFICILE TOXINS ENABLES MECHANISTIC STUDIES OF STRUCTURE/FUNCTION RELATIONSHIPS von Markham, Nicholas O., Bloch, Sarah C., Shupe, John A., Washington, Kay, Coffey, Robert J., Lacy, Borden

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Cecum axis (CecAx) preservation reveals physiological and pathological gradients in mouse gastrointestinal epithelium von Lunnemann, Hannah M., Shealy, Nicolas G., Reyzer, Michelle L., Shupe, John A., Green, Emily H., Siddiqi, Uswah, Lacy, D. Borden, Byndloss, Mariana X., Markham, Nicholas O.

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Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform von Skardal, Aleksander, Murphy, Sean V., Devarasetty, Mahesh, Mead, Ivy, Kang, Hyun-Wook, Seol, Young-Joon, Shrike Zhang, Yu, Shin, Su-Ryon, Zhao, Liang, Aleman, Julio, Hall, Adam R., Shupe, Thomas D., Kleensang, Andre, Dokmeci, Mehmet R., Jin Lee, Sang, Jackson, John D., Yoo, James J., Hartung, Thomas, Khademhosseini, Ali, Soker, Shay, Bishop, Colin E., Atala, Anthony

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Validation of the Cloud_CCI (Cloud Climate Change Initiative) cloud products in the Arctic von Vinjamuri, Kameswara S, Vountas, Marco, Lelli, Luca, Stengel, Martin, Shupe, Matthew D, Ebell, Kerstin, Burrows, John P

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Warm-air advection, air mass transformation and fog causes rapid ice melt von Tjernström, Michael, Shupe, Matthew D., Brooks, Ian M., Persson, P. Ola G., Prytherch, John, Salisbury, Dominic J., Sedlar, Joseph, Achtert, Peggy, Brooks, Barbara J., Johnston, Paul E., Sotiropoulou, Georgia, Wolfe, Dan

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Vimentin Is Required for Lung Adenocarcinoma Metastasis via Heterotypic Tumor Cell-Cancer-Associated Fibroblast Interactions during Collective Invasion von Richardson, Alessandra M, Havel, Lauren S, Koyen, Allyson E, Konen, Jessica M, Shupe, John, Wiles, 4th, W G, Martin, W David, Grossniklaus, Hans E, Sica, Gabriel, Gilbert-Ross, Melissa, Marcus, Adam I

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Arctic Summer Airmass Transformation, Surface Inversions, and the Surface Energy Budget von Tjernström, Michael, Shupe, Matthew D., Brooks, Ian M., Achtert, Peggy, Prytherch, John, Sedlar, Joseph

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Identification of Stellar Flares Using Differential Evolution Template Optimization von Lawson, Kellen D., Wisniewski, John P., Bellm, Eric C., Kowalski, Adam F., Shupe, David L.

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A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs von Skardal, Aleksander, Devarasetty, Mahesh, Kang, Hyun-Wook, Mead, Ivy, Bishop, Colin, Shupe, Thomas, Lee, Sang Jin, Jackson, John, Yoo, James, Soker, Shay, Atala, Anthony

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Estimating turbulent energy flux vertical profiles from uncrewed aircraft system measurements: exemplary results for the MOSAiC campaign von Egerer, Ulrike, Cassano, John J, Shupe, Matthew D, de Boer, Gijs, Lawrence, Dale, Doddi, Abhiram, Siebert, Holger, Jozef, Gina, Calmer, Radiance, Hamilton, Jonathan, Pilz, Christian, Lonardi, Michael

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