Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection von Peritore-Galve, F Christopher, Shupe, John A, Cave, Rory J, Childress, Kevin O, Washington, M Kay, Kuehne, Sarah A, Lacy, D Borden

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Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo von Kordus, Shannon L, Kroh, Heather K, Rodríguez, Rubén Cano, Shrem, Rebecca A, Peritore-Galve, F Christopher, Shupe, John A, Wadzinski, Brian E, Lacy, D Borden, Spiller, Benjamin W

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Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile inf... von Nabukhotna, Kateryna, Kordus, Shannon L, Shupe, John A, Cano Rodríguez, Rubén, Smith, Anna, Bohannon, Julia K, Washington, M Kay, Lacy, D Borden

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Vimentin Is Required for Lung Adenocarcinoma Metastasis via Heterotypic Tumor Cell-Cancer-Associated Fibroblast Interactions during Collective Invasion von Richardson, Alessandra M, Havel, Lauren S, Koyen, Allyson E, Konen, Jessica M, Shupe, John, Wiles, 4th, W G, Martin, W David, Grossniklaus, Hans E, Sica, Gabriel, Gilbert-Ross, Melissa, Marcus, Adam I

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Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease von Mileto, Steven J., Jardé, Thierry, Childress, Kevin O., Jensen, Jaime L., Rogers, Ashleigh P., Kerr, Genevieve, Hutton, Melanie L., Sheedlo, Michael J., Bloch, Sarah C., Shupe, John A., Horvay, Katja, Flores, Tracey, Engel, Rebekah, Wilkins, Simon, McMurrick, Paul J., Lacy, D. Borden, Abud, Helen E., Lyras, Dena

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Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection von Peritore-Galve, F. Christopher, Kaji, Izumi, Smith, Anna, Walker, Lauren M., Shupe, John A., Washington, M. Kay, Algood, Holly M. Scott, Dudeja, Pradeep K., Goldenring, James R., Lacy, D. Borden

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Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host von Wexler, Aaron G., Guiberson, Emma R., Beavers, William N., Shupe, John A., Washington, M. Kay, Lacy, D. Borden, Caprioli, Richard M., Spraggins, Jeffrey M., Skaar, Eric P.

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Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis von Markham, Nicholas O., Bloch, Sarah C., Shupe, John A., Laubacher, Erin N., Thomas, Audrey K., Kroh, Heather K., Childress, Kevin O., Peritore-Galve, F. Christopher, Washington, M. Kay, Coffey, Robert J., Lacy, D. Borden

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Cecum axis (CecAx) preservation reveals physiological and pathological gradients in mouse gastrointestinal epithelium von Lunnemann, Hannah M, Shealy, Nicolas G, Reyzer, Michelle L, Shupe, John A, Green, Emily H, Siddiqi, Uswah, Lacy, D Borden, Byndloss, Mariana X, Markham, Nicholas O

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Regulation of Sertoli-Germ Cell Adhesion and Sperm Release by FSH and Nonclassical Testosterone Signaling von Shupe, John, Cheng, Jing, Puri, Pawan, Kostereva, Nataliya, Walker, William H

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Sa1228 DELETED IN MALIGNANT BRAIN TUMORS 1 (DMBT1) GLYCOPROTEIN IS LOST IN EARLY COLONIC DYSPLASIA von Green, Emily H., Lunnemann, Hannah, Rutherford, Megan, Shupe, John A., Coffey, Robert J., Lacy, Dana B., Markham, Nicholas O.

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Modeling Discharge Rates Using a Coupled Modeled Approach for the Merced River in Yosemite National Park von Shupe, John, Potter, Christopher

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Sa1218 CECUM AXIS (CECAX) PRESERVATION REVEALS PHYSIOLOGICAL AND PATHOLOGICAL GRADIENTS IN MOUSE GASTROINTESTINAL EPITHELIUM von Lunnemann, Hannah, Shealy, Nicolas, Reyzer, Michelle, Shupe, John A., Green, Emily H., Siddiqi, Uswah, Lacy, Dana B., Byndloss, Mariana, Markham, Nicholas O.

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Mouse Spermatogenesis Requires Classical and Nonclassical Testosterone Signaling von Toocheck, Corey, Clister, Terri, Shupe, John, Crum, Chelsea, Ravindranathan, Preethi, Lee, Tae-Kyung, Ahn, Jung-Mo, Raj, Ganesh V, Sukhwani, Meena, Orwig, Kyle E, Walker, William H

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LKB1 Represses Focal Adhesion Kinase (FAK) Signaling via a FAK-LKB1 Complex to Regulate FAK Site Maturation and Directional Persistence von Kline, Erik R., Shupe, John, Gilbert-Ross, Melissa, Zhou, Wei, Marcus, Adam I.

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Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis von Farrow, Melissa A, Chumber, Nicole M, Bloch, Sarah C, King, McKenzie, Moton-Melancon, Kaycei, Shupe, John, Washington, Mary K, Spiller, Benjamin W, Lacy, D. Borden

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Abstract 2290: More than a biomarker: Studying the role of vimentin in lung cancer metastasis von Salgueiro, Alessandra M., Gilbert-Ross, Melissa, Havel, Lauren S., Shupe, John, Marcus, Adam I.

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Abstract C24: Beyond EMT: Vimentin function in lung cancer metastasis von Salgueiro, Alessandra M., Gilbert-Ross, Melissa, Havel, Lauren S., Shupe, John, Koyen, Allyson E., Grossniklaus, Hans E., Sica, Gabriel, Marcus, Adam I.

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Sa1138 MURINE INTRARECTAL INSTILLATION OF PURIFIED RECOMBINANT C. DIFFICILE TOXINS ENABLES MECHANISTIC STUDIES OF STRUCTURE/FUNCTION RELATIONSHIPS von Markham, Nicholas O., Bloch, Sarah C., Shupe, John A., Washington, Kay, Coffey, Robert J., Lacy, Borden

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Abstract B45: An early treatment window to target FAK-dependent collective invasion in Lkb1-mutant lung adenocarcinoma von Gilbert-Ross, Melissa, Konen, Jessica, Shupe, John, Koo, Junghui, Sica, Gabriel L., Ramalingam, Suresh S., Fu, Haian, Khuri, Fadlo R., Zhou, Wei, Marcus, Adam I.

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