A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit von Beal, M. Flint, Shoulson, Ira, Haas, Richard, Nutt, John G, Voss, Tiffini Smith, Ravina, Bernard, Shults, Clifford M, Snively, Victoria, Lew, Mark F, Watts, Arthur, Gao, Shan, Kompoliti, Katie, Agarwal, Pinky, Sia, Cherissa, Jog, Mandar, Cole, Linda, Sultana, Munira, Richard, Irene, Waters, Cheryl H, Figueroa, Angel, Arkun, Ani, Brodsky, Matthew, Hunter, Christine B, Palao, Alicia, So, Julie, Tetrud, James, Reys, Liza, Smith, Katharine, Singer, Carlos, Blenke, Anita, Cotto, Candace, Lannon, Margaret, Zhang, Lin, Drasby, Edward, Kumar, Rajeev, Ford, Donna Stuppy, Cote, Diane, Siderowf, Andrew D, Evatt, Marian Leslie, Sommerfeld, Barbara, Lieberman, Abraham N, Okun, Michael S, Rodriguez, Ramon L, Swartz, Camille Louise, King, Pamela, Guthrie, Stephanie, Watts, Ray L, Mari, Zoltan, Feigin, Andrew S, Shannon, Barbara, Nirenberg, Melissa Jill, Ellias, Samuel A, Glazman, Sofya, Pahwa, Rajesh, Langhammer, April, Derwent, Lorelei, Farrow, Buff, Litvan, Irene, Robinson, Annette, Sahay, Alok, Hinson, Vanessa K, Markind, Samuel, Pelikan, Melisa, Perlmutter, Joel S, Evans, Sharon, Duffy, Amy, Lind, Marlene, Elmer, Lawrence, Davis, Kathy, Spears, Julia, Wilson, Stephanie, Leehey, Maureen A, Hermanowicz, Neal, Niswonger, Shari, Shill, Holly A, Rajput, Alex, Cowper, Marilyn, Lessig, Stephanie, Fontaine, Deborah, Blindauer, Karen A, Bergholte, Jo, Uc, Ergun Y, Sieren, Jeri, Kraics, Lauren, Silver, Althea, Ingvoldstad, Christopher, Young, Jennifer, Kostyk, Sandra K, Wojcieszek, Joanne, Pfeiffer, Ronald F, Panisset, Michel, Beland, Monica, Reich, Stephen G, Zappala, Nancy, Lumina, L. Pepper, Grill, Stephen, Kellermann, Marye, Tuite, Paul, Rolandelli, Susan, Boyar, Karyn

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Natural history of multiple system atrophy in the USA: a prospective cohort study von Low, Phillip A, Prof, Reich, Stephen G, Prof, Jankovic, Joseph, Prof, Shults, Clifford W, Prof, Stern, Matthew B, Prof, Novak, Peter, MD, Tanner, Caroline M, Prof, Gilman, Sid, Prof, Marshall, Frederick J, MD, Wooten, Frederick, Prof, Racette, Brad, Prof, Chelimsky, Thomas, Prof, Singer, Wolfgang, MD, Sletten, David M, MBA, Sandroni, Paola, Prof, Mandrekar, Jay, Prof

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Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS) von Wenning, Gregor K., Tison, Franc̨ois, Seppi, Klaus, Sampaio, Cristina, Diem, Anja, Yekhlef, Farid, Ghorayeb, Imad, Ory, Fabienne, Galitzky, Monique, Scaravilli, Tommaso, Bozi, Maria, Colosimo, Carlo, Gilman, Sid, Shults, Clifford W., Quinn, Niall P., Rascol, Olivier, Poewe, Werner

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Differential neuropathological alterations in transgenic mice expressing α-synuclein from the platelet-derived growth factor and Thy-1 promoters von Rockenstein, Edward, Mallory, Margaret, Hashimoto, Makoto, Song, David, Shults, Clifford W., Lang, Ingrid, Masliah, Eliezer

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Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy von Shults, Clifford W, Rockenstein, Edward, Crews, Leslie, Adame, Anthony, Mante, Michael, Larrea, Gabriel, Hashimoto, Makoto, Song, David, Iwatsubo, Takeshi, Tsuboi, Kyoko, Masliah, Eliezer

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Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease von SHULTS, Clifford W, BEAL, M. Flint, SONG, David, FONTAINE, Deborah

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Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease von Bronstein, Jeff M., Paul, Kimberly, Yang, Laurice, Haas, Richard H., Shults, Clifford W., Le, Thuy, Ritz, Beate

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Mutations in COQ2 in Familial and Sporadic Multiple-System Atrophy von The Multiple-System Atrophy Research Collaboration

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Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease von Haas, Richard H., Nasirian, Fatemeh, Nakano, Kazutoshi, Ward, David, Pay, Mary, Hill, Robert, Shults, Clifford W.

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Potential outcome measures and trial design issues for multiple system atrophy von May, Susanne, Gilman, Sid, Sowell, B. Brooke, Thomas, Ronald G., Stern, Matthew B., Colcher, Amy, Tanner, Caroline M., Huang, Neng, Novak, Peter, Reich, Stephen G., Jankovic, Joseph, Ondo, William G., Low, Phillip A., Sandroni, Paola, Lipp, Axel, Marshall, Frederick J., Wooten, Frederick, Shults, Clifford W.

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Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects von Shults, Clifford W., Haas, Richard H., Passov, David, Beal, M. Flint

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Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia von Pankratz, Nathan, Byder, Lisa, Halter, Cheryl, Rudolph, Alice, Shults, Clifford W., Conneally, P. Michael, Foroud, Tatiana, Nichols, William C.

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Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death von Tsuboi, Kyoko, Grzesiak, John J., Bouvet, Michael, Hashimoto, Makoto, Masliah, Eliezer, Shults, Clifford W.

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Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease von Flint Beal, M., Shults, Clifford W.

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Natural History of Multiple System Atrophy in North America: A Prospective Cohort Study von Low, Phillip A., Reich, Stephen G., Jankovic, Joseph, Shults, Clifford W., Stern, Matthew B., Novak, Peter, Tanner, Caroline M., Gilman, Sid, Marshall, Frederick J., Wooten, Frederick, Racette, Brad, Chelimsky, Thomas, Singer, Wolfgang, Sletten, David M., Sandroni, Paola, Mandrekar, Jay

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α-Synuclein from platelets is not phosphorylated at serine 129 in Parkinson's disease and multiple system atrophy von Shults, Clifford W., Barrett, Jennifer M., Fontaine, Deborah

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Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients von SHULTS, C. W, BEAL, M. F, FONTAINE, D, NAKANO, K, HAAS, R. H

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G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy von Ozelius, Laurie J., Foroud, Tatiana, May, Susanne, Senthil, Geetha, Sandroni, Paola, Low, Phillip A., Reich, Stephen, Colcher, Amy, Stern, Matthew B., Ondo, William G., Jankovic, Joseph, Huang, Neng, Tanner, Caroline M., Novak, Peter, Gilman, Sid, Marshall, Frederick J., Wooten, G. Frederick, Chelimsky, Thomas C., Shults, Clifford W.

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A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease von Shults, Clifford W., Haas, Richard H., Beal, M. Flint

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Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families von Pankratz, Nathan, Nichols, William C., Uniacke, Sean K., Halter, Cheryl, Murrell, Jill, Rudolph, Alice, Shults, Clifford W., Conneally, P. Michael, Foroud, Tatiana

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