Thioredoxin and Its Reductase Are Present on Synaptic Vesicles, and Their Inhibition Prevents the Paralysis Induced by Botulinum Neurotoxins von Pirazzini, Marco, Azarnia Tehran, Domenico, Zanetti, Giulia, Megighian, Aram, Scorzeto, Michele, Fillo, Silvia, Shone, Clifford C., Binz, Thomas, Rossetto, Ornella, Lista, Florigio, Montecucco, Cesare

Volltext

Molecular features of the sortase enzyme family von Bradshaw, William J, Davies, Abigail H, Chambers, Christopher J, Roberts, April K, Shone, Clifford C, Acharya, K. Ravi

Volltext

Super toxins from a super bug: structure and function of Clostridium difficile toxins von Davies, Abigail H, Roberts, April K, Shone, Clifford C, Acharya, K Ravi

Volltext

A Novel, Orally Delivered Antibody Therapy and Its Potential to Prevent Clostridioides difficile Infection in Pre-clinical Models von Roberts, April K., Harris, Hannah C., Smith, Michael, Giles, Joanna, Polak, Oktawia, Buckley, Anthony M., Clark, Emma, Ewin, Duncan, Moura, Ines B., Spitall, William, Shone, Clifford C., Wilcox, Mark, Chilton, Caroline, Donev, Rossen

Volltext

Cwp84, a Surface-associated Cysteine Protease, Plays a Role in the Maturation of the Surface Layer of Clostridium difficile von Kirby, Jonathan M., Ahern, Helen, Roberts, April K., Kumar, Vivek, Freeman, Zoe, Acharya, K.Ravi, Shone, Clifford C.

Volltext

A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins von Azarnia Tehran, Domenico, Zanetti, Giulia, Leka, Oneda, Lista, Florigio, Fillo, Silvia, Binz, Thomas, Shone, Clifford C., Rossetto, Ornella, Montecucco, Cesare, Paradisi, Cristina, Mattarei, Andrea, Pirazzini, Marco

Volltext

The thioredoxin reductase – Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles von Pirazzini, Marco, Tehran, Domenico Azarnia, Zanetti, Giulia, Lista, Florigio, Binz, Thomas, Shone, Clifford C., Rossetto, Ornella, Montecucco, Cesare

Volltext

Structure and function of a Clostridium difficile sortase enzyme von Chambers, Christopher J., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

Volltext

Genomes of Escherichia coli bacteraemia isolates originating from urinary tract foci contain more virulence-associated genes than those from non-urinary foci and neutropaenic hosts von Dale, Adam P., Pandey, Anish K., Hesp, Richard J., Belogiannis, Konstantinos, Laver, Jay R., Shone, Clifford C., Read, Robert C.

Volltext

Structural Basis for Substrate Recognition in the Enzymatic Component of ADP-ribosyltransferase Toxin CDTa from Clostridium difficile von Sundriyal, Amit, Roberts, April K., Shone, Clifford C., Acharya, K.Ravi

Volltext

Confocal Endomicroscopy of Neuromuscular Junctions Stained with Physiologically Inert Protein Fragments of Tetanus Toxin von Roesl, Cornelia, Evans, Elizabeth R, Dissanayake, Kosala N, Boczonadi, Veronika, Jones, Ross A, Jordan, Graeme R, Ledahawsky, Leire, Allen, Guy C C, Scott, Molly, Thomson, Alanna, Wishart, Thomas M, Hughes, David I, Mead, Richard J, Shone, Clifford C, Slater, Clarke R, Gillingwater, Thomas H, Skehel, Paul A, Ribchester, Richard R

Volltext

Expression, purification and cell cytotoxicity of actin-modifying binary toxin from Clostridium difficile von Sundriyal, Amit, Roberts, April K., Ling, Roger, McGlashan, Joanna, Shone, Clifford C., Acharya, K. Ravi

Volltext

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals von Pirazzini, Marco, Bordin, Fulvio, Rossetto, Ornella, Shone, Clifford C., Binz, Thomas, Montecucco, Cesare

Volltext

Double anchorage to the membrane and intact inter‐chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons von Pirazzini, Marco, Rossetto, Ornella, Bolognese, Paolo, Shone, Clifford C., Montecucco, Cesare

Volltext

Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism von Zanetti, Giulia, Azarnia Tehran, Domenico, Pirazzini, Marcon, Binz, Thomas, Shone, Clifford C., Fillo, Silvia, Lista, Florigio, Rossetto, Ornella, Montecucco, Cesare

Volltext

Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro von Bradshaw, William J., Kirby, Jonathan M., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

Volltext

A family of killer toxins. Exploring the mechanism of ADP-ribosylating toxins von Holbourn, Kenneth P, Shone, Clifford C, Acharya, K R

Volltext

The structure of the S-layer of Clostridium difficile von Bradshaw, William J., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

Volltext

The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile von Bradshaw, William J., Kirby, Jonathan M., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

Volltext

Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons von Pirazzini, Marco, Rossetto, Ornella, Bertasio, Cristina, Bordin, Fulvio, Shone, Clifford C., Binz, Thomas, Montecucco, Cesare

Volltext