The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia von Pappano, William N, Guo, Jun, He, Yupeng, Ferguson, Debra, Jagadeeswaran, Sujatha, Osterling, Donald J, Gao, Wenqing, Spence, Julie K, Pliushchev, Marina, Sweis, Ramzi F, Buchanan, Fritz G, Michaelides, Michael R, Shoemaker, Alexander R, Tse, Chris, Chiang, Gary G

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor von Tse, Christin, Shoemaker, Alexander R, Adickes, Jessica, Anderson, Mark G, Chen, Jun, Jin, Sha, Johnson, Eric F, Marsh, Kennan C, Mitten, Michael J, Nimmer, Paul, Roberts, Lisa, Tahir, Stephen K, Xiao, Yu, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen, Rosenberg, Saul H, Elmore, Steven W

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Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins von Park, Cheol-Min, Bruncko, Milan, Adickes, Jessica, Bauch, Joy, Ding, Hong, Kunzer, Aaron, Marsh, Kennan C, Nimmer, Paul, Shoemaker, Alexander R, Song, Xiaohong, Tahir, Stephen K, Tse, Christin, Wang, Xilu, Wendt, Michael D, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

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Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315 von Jakob, Clarissa G, Upadhyay, Anup K, Donner, Pamela L, Nicholl, Emily, Addo, Sadiya N, Qiu, Wei, Ling, Christopher, Gopalakrishnan, Sujatha M, Torrent, Maricel, Cepa, Steven P, Shanley, Jason, Shoemaker, Alexander R, Sun, Chaohong C, Vasudevan, Anil, Woller, Kevin R, Shotwell, J. Brad, Shaw, Bailin, Bian, Zhiguo, Hutti, Jessica E

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Ubiquitin-specific Cysteine Protease 2a (USP2a) Regulates the Stability of Aurora-A von Shi, Yan, Solomon, Larry R., Pereda-Lopez, Ana, Giranda, Vincent L., Luo, Yan, Johnson, Eric F., Shoemaker, Alexander R., Leverson, Joel, Liu, Xuesong

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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer von Oost, Thorsten K, Sun, Chaohong, Armstrong, Robert C, Al-Assaad, Ali-Samer, Betz, Stephen F, Deckwerth, Thomas L, Ding, Hong, Elmore, Steven W, Meadows, Robert P, Olejniczak, Edward T, Oleksijew, Andrew, Oltersdorf, Tilman, Rosenberg, Saul H, Shoemaker, Alexander R, Tomaselli, Kevin J, Zou, Hua, Fesik, Stephen W

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The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo von Ackler, Scott, Mitten, Michael J., Foster, Kelly, Oleksijew, Anatol, Refici, Marion, Tahir, Stephen K., Xiao, Yu, Tse, Christin, Frost, David J., Fesik, Stephen W., Rosenberg, Saul H., Elmore, Steven W., Shoemaker, Alexander R.

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Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways von Liu, Xuesong, Han, Edward K, Anderson, Mark, Shi, Yan, Semizarov, Dimitri, Wang, Gang, McGonigal, Thomas, Roberts, Lisa, Lasko, Loren, Palma, Joann, Zhu, Gui-Dong, Penning, Thomas, Rosenberg, Saul, Giranda, Vincent L, Luo, Yan, Leverson, Joel, Johnson, Eric F, Shoemaker, Alexander R

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Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor von XUESONG LIU, YAN SHI, XU, Allison J, LAYER, Ramesh, HARLAN, John E, SOLOMON, Larry R, DONAWHO, Cherrie K, PENNING, Thomas D, JOHNSON, Eric F, SHOEMAKER, Alexander R, MAAG, David X, PALMA, Joann P, PATTERSON, Melanie J, ELLIS, Paul A, SURBER, Bruce W, READY, Damien B, SONI, Niru B, LADROR, Uri S

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Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195 von Tong, Yunsong, Stewart, Kent D, Florjancic, Alan S, Harlan, John E, Merta, Philip J, Przytulinska, Magdalena, Soni, Nirupama, Swinger, Kerren K, Zhu, Haizhong, Johnson, Eric F, Shoemaker, Alexander R, Penning, Thomas D

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Corrigendum to “Investigation of biaryl heterocycles as inhibitors of Wee1 kinase” [Bioorg. Med. Chem. Lett. 29 (2019) 1481–1486] von Mastracchio, Anthony, Lai, Chunqiu, Torrent, Maricel, Bromberg, Kenneth, Buchanan, Fritz G., Ferguson, Debra, Bontcheva, Velitchka, Johnson, Eric F., Lasko, Loren, Maag, David, Shoemaker, Alexander R., Penning, Thomas D.

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Investigation of biaryl heterocycles as inhibitors of Wee1 kinase von Mastracchio, Anthony, Lai, Chunqiu, Torrent, Maricel, Bromberg, Kenneth, Buchanan, Fritz G., Ferguson, Debra, Bontcheva, Velitchka, Johnson, Eric F., Lasko, Loren, Maag, David, Shoemaker, Alexander R., Penning, Thomas D.

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Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo von Shi, Yan, Liu, Xuesong, Han, Edward K., Guan, Ran, Shoemaker, Alexander R., Oleksijew, Anatol, Woods, Keith W., Fisher, John P., Klinghofer, Vered, Lasko, Loren, McGonigal, Thomas, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L., Luo, Yan

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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo von Luo, Yan, Shoemaker, Alexander R, Liu, Xuesong, Woods, Keith W, Thomas, Sheela A, de Jong, Ron, Han, Edward K, Li, Tongmei, Stoll, Vincent S, Powlas, Jessica A, Oleksijew, Anatol, Mitten, Michael J, Shi, Yan, Guan, Ran, McGonigal, Thomas P, Klinghofer, Vered, Johnson, Eric F, Leverson, Joel D, Bouska, Jennifer J, Mamo, Mulugeta, Smith, Richard A, Gramling-Evans, Emily E, Zinker, Bradley A, Mika, Amanda K, Nguyen, Phong T, Oltersdorf, Tilman, Rosenberg, Saul H, Li, Qun, Giranda, Vincent L

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Rapamycin Inhibits Akt-Mediated Oncogenic Transformation and Tumor Growth von Liu, Xuesong, Powlas, Jessica, Shi, Yan, Oleksijew, Anatol X, Shoemaker, Alexander R, De Jong, Ron, Oltersdorf, Tilman, Giranda, Vincent L, Luo, Yan

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Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo von Wendt, Michael D, Shen, Wang, Kunzer, Aaron, McClellan, William J, Bruncko, Milan, Oost, Thorsten K, Ding, Hong, Joseph, Mary K, Zhang, Haichao, Nimmer, Paul M, Ng, Shi-Chung, Shoemaker, Alexander R, Petros, Andrew M, Oleksijew, Anatol, Marsh, Kennan, Bauch, Joy, Oltersdorf, Tilman, Belli, Barbara A, Martineau, Darlene, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

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Aminopyrimidinone Cdc7 Kinase Inhibitors von Woods, Keith W., Lai, Chunqiu, Miyashiro, Julie M., Tong, Yunsong, Florjancic, Alan S., Han, Edward K., Soni, Niru, Shi, Yan, Lasko, Loren, Leverson, Joel D., Johnson, Eric F., Shoemaker, Alexander R., Penning, Thomas D.

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Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors von Zhang, Qingwei, Xia, Zhiren, Mitten, Michael J., Lasko, Loren M., Klinghofer, Vered, Bouska, Jennifer, Johnson, Eric F., Penning, Thomas D., Luo, Yan, Giranda, Vincent L., Shoemaker, Alexander R., Stewart, Kent D., Djuric, Stevan W., Vasudevan, Anil

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Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL von Bruncko, Milan, Oost, Thorsten K, Belli, Barbara A, Ding, Hong, Joseph, Mary K, Kunzer, Aaron, Martineau, Darlene, McClellan, William J, Mitten, Michael, Ng, Shi-Chung, Nimmer, Paul M, Oltersdorf, Tilman, Park, Cheol-Min, Petros, Andrew M, Shoemaker, Alexander R, Song, Xiaohong, Wang, Xilu, Wendt, Michael D, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W

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Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase von Tong, Yunsong, Torrent, Maricel, Florjancic, Alan S, Bromberg, Kenneth D, Buchanan, Fritz G, Ferguson, Debra C, Johnson, Eric F, Lasko, Loren M, Maag, David, Merta, Philip J, Olson, Amanda M, Osterling, Donald J, Soni, Nirupama, Shoemaker, Alexander R, Penning, Thomas D

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