A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects von Bonaventure, Pascal, Yun, Sujin, Johnson, Philip L, Shekhar, Anantha, Fitz, Stephanie D, Shireman, Brock T, Lebold, Terry P, Nepomuceno, Diane, Lord, Brian, Wennerholm, Michelle, Shelton, Jonathan, Carruthers, Nicholas, Lovenberg, Timothy, Dugovic, Christine

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Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism von Dugovic, Christine, Shelton, Jonathan E, Yun, Sujin, Bonaventure, Pascal, Shireman, Brock T, Lovenberg, Timothy W

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Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans von Salvadore, Giacomo, Bonaventure, Pascal, Shekhar, Anantha, Johnson, Philip L., Lord, Brian, Shireman, Brock T., Lebold, Terry P., Nepomuceno, Diane, Dugovic, Christine, Brooks, Sander, Zuiker, Rob, Bleys, Cathy, Tatikola, Kanaka, Remmerie, Bart, Jacobs, Gabriel E., Schruers, Koen, Moyer, John, Nash, Abigail, Van Nueten, Luc G. M., Drevets, Wayne C.

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Direct Catalytic Asymmetric Aldol Additions of Methyl Ynones. Spontaneous Reversal in the Sense of Enantioinduction von Trost, Barry M, Fettes, Alec, Shireman, Brock T

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Copper-mediated synthesis of drug-like bicyclopentanes von Zhang, Xiaheng, Smith, Russell T., Le, Chip, McCarver, Stefan J., Shireman, Brock T., Carruthers, Nicholas I., MacMillan, David W. C.

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Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice von Yun, Sujin, Wennerholm, Michelle, Shelton, Jonathan E, Bonaventure, Pascal, Letavic, Michael A, Shireman, Brock T, Lovenberg, Timothy W, Dugovic, Christine

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Dinuclear Asymmetric Zn Aldol Additions:  Formal Asymmetric Synthesis of Fostriecin von Trost, Barry M, Frederiksen, Mathias U, Papillon, Julien P. N, Harrington, Paul E, Shin, Seunghoon, Shireman, Brock T

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Selective orexin receptor antagonists von Lebold, Terry P., Bonaventure, Pascal, Shireman, Brock T.

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Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D) von Wang, Jocelyn, Nakafuku, Kohki M., Ziff, Jeannie, Gelin, Christine F., Gholami, Hadi, Thompson, Aaron A., Karpowich, Nathan K., Limon, Luis, Coate, Heather R., Damm-Ganamet, Kelly L., Shih, Amy Y., Grant, Joanna C., Côte, Marjorie, Mak, Puiying A., Pascual, Heather A., Rives, Marie-Laure, Edwards, James P., Venable, Jennifer D., Venkatesan, Hariharan, Shi, Zhicai, Allen, Samantha J., Sharma, Sujata, Kung, Pei-Pei, Shireman, Brock T.

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Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions von McCarver, Stefan, Hanna, Luke, Samant, Andrew, Thompson, Aaron A., Seierstad, Mark, Saha, Arjun, Wu, Dongpei, Lord, Brian, Sutton, Steven W., Shah, Vishal, Milligan, Cynthia M., Wennerholm, Michelle, Shelton, Jonathan, Lebold, Terry P., Shireman, Brock T.

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Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate von Letavic, Michael A., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Koudriakova, Tatiana, Lord, Brian, Lovenberg, Timothy W., Ly, Kiev S., Mani, Neelakandha S., Nepomuceno, Diane, Pippel, Daniel J., Rizzolio, Michele, Shelton, Jonathan E., Shah, Chandra R., Shireman, Brock T., Young, Lana K., Yun, Sujin

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Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin‑1 Antagonists: Discovery of JNJ-54717793 von Préville, Cathy, Bonaventure, Pascal, Koudriakova, Tatiana, Lord, Brian, Nepomuceno, Diane, Rizzolio, Michele, Mani, Neelakandha, Coe, Kevin J, Ndifor, Anthony, Dugovic, Christine, Dvorak, Curt A, Coate, Heather, Pippel, Daniel J, Fitzgerald, Anne, Allison, Brett, Lovenberg, Timothy W, Carruthers, Nicholas I, Shireman, Brock T

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Substituted 5,6-(Dihydropyrido[3,4‑d]pyrimidin-7(8H)‑yl)-methanones as P2X7 Antagonists von Ziff, Jeannie, Rudolph, Dale A, Stenne, Brice, Koudriakova, Tatiana, Lord, Brian, Bonaventure, Pascal, Lovenberg, Timothy W, Carruthers, Nicholas I, Bhattacharya, Anindya, Letavic, Michael A, Shireman, Brock T

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Pharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex von Aluisio, Leah, Fraser, Ian, Berdyyeva, Tamara, Tryputsen, Volha, Shireman, Brock T, Shoblock, James, Lovenberg, Timothy, Dugovic, Christine, Bonaventure, Pascal

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A Practical Synthesis of Regioisomeric 6- and 7-Methoxytetrahydro-3-benzazepines von Liang, Jimmy T, Liu, Jing, Shireman, Brock T, Tran, Vi, Deng, Xiaohu, Mani, Neelakandha S

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2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists von SHIREMAN, Brock T, DVORAK, Curt A, RUDOLPH, Dale A, BONAVENTURE, Pascal, NEPOMUCENO, Diane, DVORAK, Lisa, MILLER, Kirsten L, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I

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Rapid syntheses of either enantiomer of important carbocyclic nucleoside precursors von Shireman, Brock T, Miller, Marvin J

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Synthesis of Enantiomerically and Diastereomerically Pure 2(S)-Amino-6(R)-hydroxy-1,7-heptanedioic Acid Dimethyl Ester Hydrochloride from Cycloheptadiene von Shireman, Brock T, Miller, Marvin J

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Conformational Study and Enantioselective, Regiospecific Syntheses of Novel Aminoxy trans-Proline Analogues Derived from an Acylnitroso Diels−Alder Cycloaddition von Shireman, Brock T, Miller, Marvin J, Jonas, Marco, Wiest, Olaf

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Identification of small-molecule protein-protein interaction inhibitors for NKG2D von Thompson, Aaron A, Harbut, Michael B, Kung, Pei-Pei, Karpowich, Nathan K, Branson, Jeffrey D, Grant, Joanna C, Hagan, Deborah, Pascual, Heather A, Bai, Guoyun, Zavareh, Reza Beheshti, Coate, Heather R, Collins, Bernard C, Côte, Marjorie, Gelin, Christine F, Damm-Ganamet, Kelly L, Gholami, Hadi, Huff, Adam R, Limon, Luis, Lumb, Kevin J, Mak, Puiying A, Nakafuku, Kohki M, Price, Edmund V, Shih, Amy Y, Tootoonchi, Mandana, Vellore, Nadeem A, Wang, Jocelyn, Wei, Na, Ziff, Jeannie, Berger, Scott B, Edwards, James P, Gardet, Agnès, Sun, Siquan, Towne, Jennifer E, Venable, Jennifer D, Shi, Zhicai, Venkatesan, Hariharan, Rives, Marie-Laure, Sharma, Sujata, Shireman, Brock T, Allen, Samantha J

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