A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells von Ishikawa, Yoshinori, Gamo, Kanae, Yabuki, Masato, Takagi, Shinji, Toyoshima, Kosei, Nakayama, Kazuhide, Nakayama, Akiko, Morimoto, Megumi, Miyashita, Hitoshi, Dairiki, Ryo, Hikichi, Yukiko, Tomita, Naoki, Tomita, Daisuke, Imamura, Shinichi, Iwatani, Misa, Kamada, Yusuke, Matsumoto, Satoru, Hara, Ryujiro, Nomura, Toshiyuki, Tsuchida, Ken, Nakamura, Kazuhide

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Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase von Tanaka, Yuta, Kurasawa, Osamu, Yokota, Akihiro, Klein, Michael G, Ono, Koji, Saito, Bunnai, Matsumoto, Shigemitsu, Okaniwa, Masanori, Ambrus-Aikelin, Geza, Morishita, Daisuke, Kitazawa, Satoshi, Uchiyama, Noriko, Ogawa, Kazumasa, Kimura, Hiromichi, Imamura, Shinichi

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A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain von Sakai, Takayuki, Ogata, Aya, Ikenuma, Hiroshi, Yamada, Takashi, Hattori, Saori, Abe, Junichiro, Imamura, Shinichi, Ichise, Masanori, Tada, Mari, Kakita, Akiyoshi, Koyama, Hiroko, Suzuki, Masaaki, Kato, Takashi, Ito, Kengo, Kimura, Yasuyuki

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Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors von Miyamoto, Naoki, Oguro, Yuya, Takagi, Terufumi, Iwata, Hidehisa, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi

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Anti‐angiogenic and anti‐tumor effects of TAK‐593, a potent and selective inhibitor of vascular endothelial growth factor and platelet‐derived growth factor receptor tyrosine kinas... von Awazu, Yoshiko, Mizutani, Akio, Nagase, Yoshinori, Tsuchiya, Shuntarou, Nakamura, Kazuhide, Kakoi, Yuichi, Kitahara, Osamu, Takeuchi, Toshiyuki, Yamasaki, Seiji, Miyamoto, Naoki, Iwata, Hidehisa, Miki, Hiroshi, Imamura, Shinichi, Hori, Akira

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Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2‑a]pyrazine Scaffold as a Novel Proline Mimetic von Hashimoto, Kentaro, Saito, Bunnai, Miyamoto, Naoki, Oguro, Yuya, Tomita, Daisuke, Shiokawa, Zenyu, Asano, Moriteru, Kakei, Hiroyuki, Taya, Naohiro, Kawasaki, Masanori, Sumi, Hiroyuki, Yabuki, Masato, Iwai, Kenichi, Yoshida, Sei, Yoshimatsu, Mie, Aoyama, Kazunobu, Kosugi, Yohei, Kojima, Takashi, Morishita, Nao, Dougan, Douglas R, Snell, Gyorgy P, Imamura, Shinichi, Ishikawa, Tomoyasu

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A novel pyrrolo[3, 2‐d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet‐derived growth factor receptor tyrosine kinase inhibitor, shows potent a... von Awazu, Yoshiko, Mizutani, Akio, Nagase, Yoshinori, Iwata, Hidehisa, Oguro, Yuya, Miki, Hiroshi, Imamura, Shinichi, Hori, Akira

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Discovery of N -[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2- b ]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1 H -pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 ki... von Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi

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CCR5 Antagonists as Anti-HIV-1 Agents. 1. Synthesis and Biological Evaluation of 5-Oxopyrrolidine-3-carboxamide Derivatives von Imamura, Shinichi, Ishihara, Yuji, Hattori, Taeko, Kurasawa, Osamu, Matsushita, Yoshihiro, Sugihara, Yoshihiro, Kanzaki, Naoyuki, Iizawa, Yuji, Baba, Masanori, Hashiguchi, Shohei

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Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo-[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation von OGURO, Yuya, MIYAMOTO, Naoki, OKADA, Kengo, TAKAGI, Terufumi, IWATA, Hidehisa, AWAZU, Yoshiko, MIKI, Hiroshi, HORI, Akira, KAMIYAMA, Keiji, IMAMURA, Shinichi

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Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors von Matsumoto, Shigemitsu, Miyamoto, Naoki, Hirayama, Takaharu, Oki, Hideyuki, Okada, Kengo, Tawada, Michiko, Iwata, Hidehisa, Nakamura, Kazuhide, Yamasaki, Seiji, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi

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CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]- N, N′-diphenylureas von Imamura, Shinichi, Kurasawa, Osamu, Nara, Yoshi, Ichikawa, Takashi, Nishikawa, Youichi, Iida, Takehiro, Hashiguchi, Shohei, Kanzaki, Naoyuki, Iizawa, Yuji, Baba, Masanori, Sugihara, Yoshihiro

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Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase... von Miyamoto, Naoki, Sakai, Nozomu, Hirayama, Takaharu, Miwa, Kazuhiro, Oguro, Yuya, Oki, Hideyuki, Okada, Kengo, Takagi, Terufumi, Iwata, Hidehisa, Awazu, Yoshiko, Yamasaki, Seiji, Takeuchi, Toshiyuki, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi

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Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents von Kojima, Takuto, Asano, Yasutomi, Kurasawa, Osamu, Hirata, Yasuhiro, Iwamura, Naoki, Wong, Tzu-Tshin, Saito, Bunnai, Tanaka, Yuta, Arai, Ryosuke, Yonemori, Kazuko, Miyamoto, Yasufumi, Sagiya, Yoji, Yaguchi, Masahiro, Shibata, Sachio, Mizutani, Akio, Sano, Osamu, Adachi, Ryutaro, Satomi, Yoshinori, Hirayama, Megumi, Aoyama, Kazunobu, Hiura, Yuto, Kiba, Atsushi, Kitamura, Shuji, Imamura, Shinichi

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Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: Discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics von Oguro, Yuya, Cary, Douglas R., Miyamoto, Naoki, Tawada, Michiko, Iwata, Hidehisa, Miki, Hiroshi, Hori, Akira, Imamura, Shinichi

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Biochemical Characterization of TAK-593, a Novel VEGFR/PDGFR Inhibitor with a Two-Step Slow Binding Mechanism von Iwata, Hidehisa, Imamura, Shinichi, Hori, Akira, Hixon, Mark S, Kimura, Hiroyuki, Miki, Hiroshi

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A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities von Awazu, Yoshiko, Nakamura, Kazuhide, Mizutani, Akio, Kakoi, Yuichi, Iwata, Hidehisa, Yamasaki, Seiji, Miyamoto, Naoki, Imamura, Shinichi, Miki, Hiroshi, Hori, Akira

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Evaluation of specific binding of 11CTZ7774 to the receptor-interacting protein kinase 1 (RIPK1) in the brain von Sakai, Takayuki, Yamada, Takashi, Ikenuma, Hiroshi, Ogata, Aya, Ichise, Masanori, Hattori, Saori, Abe, Junichiro, Tada, Mari, Kakita, Akiyoshi, Suzuki, Masaaki, Ito, Kengo, Kato, Takashi, Imamura, Shinichi, Kimura, Yasuyuki

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Evaluation of specific binding of [ 11 C]TZ7774 to the receptor-interacting protein kinase 1 (RIPK1) in the brain von Sakai, Takayuki, Yamada, Takashi, Ikenuma, Hiroshi, Ogata, Aya, Ichise, Masanori, Hattori, Saori, Abe, Junichiro, Tada, Mari, Kakita, Akiyoshi, Suzuki, Masaaki, Ito, Kengo, Kato, Takashi, Imamura, Shinichi, Kimura, Yasuyuki

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New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase von Tanaka, Yuta, Kurasawa, Osamu, Yokota, Akihiro, Klein, Michael G, Saito, Bunnai, Matsumoto, Shigemitsu, Okaniwa, Masanori, Ambrus-Aikelin, Geza, Uchiyama, Noriko, Morishita, Daisuke, Kimura, Hiromichi, Imamura, Shinichi

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