Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons von Jo, Junghyun, Xiao, Yixin, Sun, Alfred Xuyang, Cukuroglu, Engin, Tran, Hoang-Dai, Göke, Jonathan, Tan, Zi Ying, Saw, Tzuen Yih, Tan, Cheng-Peow, Lokman, Hidayat, Lee, Younghwan, Kim, Donghoon, Ko, Han Seok, Kim, Seong-Oh, Park, Jae Hyeon, Cho, Nam-Joon, Hyde, Thomas M., Kleinman, Joel E., Shin, Joo Heon, Weinberger, Daniel R., Tan, Eng King, Je, Hyunsoo Shawn, Ng, Huck-Hui

Volltext

A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder von Phan, BaDoi N., Bohlen, Joseph F., Davis, Brittany A., Ye, Zengyou, Chen, Huei-Ying, Mayfield, Brent, Sripathy, Srinidhi Rao, Cerceo Page, Stephanie, Campbell, Morganne N., Smith, Hannah L., Gallop, Danisha, Kim, Hyojin, Thaxton, Courtney L., Simon, Jeremy M., Burke, Emily E., Shin, Joo Heon, Kennedy, Andrew J., Sweatt, J. David, Philpot, Benjamin D., Jaffe, Andrew E., Maher, Brady J.

Volltext

SynGAP isoforms differentially regulate synaptic plasticity and dendritic development von Araki, Yoichi, Hong, Ingie, Gamache, Timothy R., Ju, Shaowen, Collado-Torres, Leonardo, Shin, Joo Heon, Huganir, Richard L.

Volltext

Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1 von Rannals, Matthew D., Hamersky, Gregory R., Page, Stephanie Cerceo, Campbell, Morganne N., Briley, Aaron, Gallo, Ryan A., Phan, BaDoi N., Hyde, Thomas M., Kleinman, Joel E., Shin, Joo Heon, Jaffe, Andrew E., Weinberger, Daniel R., Maher, Brady J.

Volltext

Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19) von Ma, Liang, Semick, Stephen A., Chen, Qiang, Li, Chao, Tao, Ran, Price, Amanda J., Shin, Joo Heon, Jia, Yankai, Brandon, Nicholas J., Cross, Alan J., Hyde, Thomas M., Kleinman, Joel E., Jaffe, Andrew E., Weinberger, Daniel R., Straub, Richard E.

Volltext

Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors von Choi, In Young, Lim, Hotae, Cho, Hyeon Jin, Oh, Yohan, Chou, Bin-Kuan, Bai, Hao, Cheng, Linzhao, Kim, Yong Jun, Hyun, SangHwan, Kim, Hyesoo, Shin, Joo Heon, Lee, Gabsang

Volltext

Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures von Hartley, Iain, Elkhoury, Fuad F, Heon Shin, Joo, Xie, Bin, Gu, Xiangqun, Gao, Yuan, Zhou, Dan, Haddad, Gabriel G

Volltext

KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits von Ren, Ming, Hu, Zhonghua, Chen, Qiang, Jaffe, Andrew, Li, Yingbo, Sadashivaiah, Vijay, Zhu, Shujuan, Rajpurohit, Nina, Heon Shin, Joo, Xia, Wei, Jia, Yankai, Wu, Jingxian, Lang Qin, Sunny, Li, Xinjian, Zhu, Jian, Tian, Qingjun, Paredes, Daniel, Zhang, Fengyu, Wang, Kuan Hong, Mattay, Venkata S., Callicott, Joseph H., Berman, Karen F., Weinberger, Daniel R., Yang, Feng

Volltext

BDNF-TrkB signaling in oxytocin neurons contributes to maternal behavior von Maynard, Kristen R, Hobbs, John W, Phan, BaDoi N, Gupta, Amolika, Rajpurohit, Sumita, Williams, Courtney, Rajpurohit, Anandita, Shin, Joo Heon, Jaffe, Andrew E, Martinowich, Keri

Volltext

Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice von Kim, Hyojung, Huh, Yu-Jin, Kim, Ji Hun, Jo, Minkyung, Shin, Joo-Heon, Park, Sang Chul, Ahn, Jee-Yin, Lee, Yun-Il, Lee, Yunjong

Volltext

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain von Guo, Junjie U, Su, Yijing, Shin, Joo Heon, Shin, Jaehoon, Li, Hongda, Xie, Bin, Zhong, Chun, Hu, Shaohui, Le, Thuc, Fan, Guoping, Zhu, Heng, Chang, Qiang, Gao, Yuan, Ming, Guo-li, Song, Hongjun

Volltext

Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates von Micali, Nicola, Kim, Suel-Kee, Diaz-Bustamante, Marcelo, Stein-O’Brien, Genevieve, Seo, Seungmae, Shin, Joo-Heon, Rash, Brian G., Ma, Shaojie, Wang, Yanhong, Olivares, Nicolas A., Arellano, Jon I., Maynard, Kristen R., Fertig, Elana J., Cross, Alan J., Bürli, Roland W., Brandon, Nicholas J., Weinberger, Daniel R., Chenoweth, Joshua G., Hoeppner, Daniel J., Sestan, Nenad, Rakic, Pasko, Colantuoni, Carlo, McKay, Ronald D.

Volltext

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis von Jaffe, Andrew E., Straub, Richard E., Shin, Joo Heon, Tao, Ran, Gao, Yuan, Collado-Torres, Leonardo, Kam-Thong, Tony, Xi, Hualin S., Quan, Jie, Chen, Qiang, Colantuoni, Carlo, Ulrich, William S., Maher, Brady J., Deep-Soboslay, Amy, Cross, Alan J., Brandon, Nicholas J., Leek, Jeffrey T., Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.

Volltext

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain von Radulescu, Eugenia, Jaffe, Andrew E., Straub, Richard E., Chen, Qiang, Shin, Joo Heon, Hyde, Thomas M., Kleinman, Joel E, Weinberger, Daniel R.

Volltext

Recognition of Partially Occluded and Rotated Images With a Network of Spiking Neurons von Joo-Heon Shin, Smith, David, Swiercz, Waldemar, Staley, Kevin, Rickard, J Terry, Montero, Javier, Kurgan, Lukasz A, Cios, Krzysztof J

Volltext

Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq von Gådin, Jesper R, Buil, Alfonso, Colantuoni, Carlo, Jaffe, Andrew E, Nielsen, Jacob, Shin, Joo-Heon, Hyde, Thomas M, Kleinman, Joel E, Plath, Niels, Eriksson, Per, Brunak, Søren, Didriksen, Michael, Weinberger, Daniel R, Folkersen, Lasse

Volltext

Dynamic regulation of RNA editing in human brain development and disease von Hwang, Taeyoung, Park, Chul-Kee, Leung, Anthony K L, Gao, Yuan, Hyde, Thomas M, Kleinman, Joel E, Rajpurohit, Anandita, Tao, Ran, Shin, Joo Heon, Weinberger, Daniel R

Volltext

Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas von Hwang, Taeyoung, Kim, Sojin, Chowdhury, Tamrin, Yu, Hyeon Jong, Kim, Kyung-Min, Kang, Ho, Won, Jae-Kyung, Park, Sung-Hye, Shin, Joo Heon, Park, Chul-Kee

Volltext

Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk von Jaffe, Andrew E., Hoeppner, Daniel J., Saito, Takeshi, Blanpain, Lou, Ukaigwe, Joy, Burke, Emily E., Collado-Torres, Leonardo, Tao, Ran, Tajinda, Katsunori, Maynard, Kristen R., Tran, Matthew N., Martinowich, Keri, Deep-Soboslay, Amy, Shin, Joo Heon, Kleinman, Joel E., Weinberger, Daniel R., Matsumoto, Mitsuyuki, Hyde, Thomas M.

Volltext

Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods von Wright, Carrie, Rajpurohit, Anandita, Burke, Emily E, Williams, Courtney, Collado-Torres, Leonardo, Kimos, Martha, Brandon, Nicholas J, Cross, Alan J, Jaffe, Andrew E, Weinberger, Daniel R, Shin, Joo Heon

Volltext