The Spatial Distribution of Water Components with Similar T2 May Provide Insight into Pathways for Large Molecule Transportation in the Brain von Oshio, Koichi, Yui, Masao, Shimizu, Seiko, Yamada, Shinya

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SNP-based heritability estimates of gout and its subtypes determined by genome-wide association studies of clinically defined gout von Toyoda, Yu, Nakatochi, Masahiro, Nakayama, Akiyoshi, Kawamura, Yusuke, Nakaoka, Hirofumi, Wakai, Kenji, Matsuo, Keitaro, Matsuo, Hirotaka

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Genetic epidemiological analysis of hypouricaemia from 4993 Japanese on non-functional variants of URAT1/SLC22A12 gene von Nakayama, Akiyoshi, Kawamura, Yusuke, Toyoda, Yu, Shimizu, Seiko, Kawaguchi, Makoto, Aoki, Yuka, Takeuchi, Kenji, Okada, Rieko, Kubo, Yoko, Imakiire, Toshihiko, Iwasawa, Satoko, Nakashima, Hiroshi, Tsunoda, Masashi, Ito, Keiichi, Kumagai, Hiroo, Takada, Tappei, Ichida, Kimiyoshi, Shinomiya, Nariyoshi, Matsuo, Hirotaka

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Common dysfunctional variants in ABCG2 are a major cause of early-onset gout von Matsuo, Hirotaka, Ichida, Kimiyoshi, Takada, Tappei, Nakayama, Akiyoshi, Nakashima, Hiroshi, Nakamura, Takahiro, Kawamura, Yusuke, Takada, Yuzo, Yamamoto, Ken, Inoue, Hiroki, Oikawa, Yuji, Naito, Mariko, Hishida, Asahi, Wakai, Kenji, Okada, Chisa, Shimizu, Seiko, Sakiyama, Masayuki, Chiba, Toshinori, Ogata, Hiraku, Niwa, Kazuki, Hosoyamada, Makoto, Mori, Atsuyoshi, Hamajima, Nobuyuki, Suzuki, Hiroshi, Kanai, Yoshikatsu, Sakurai, Yutaka, Hosoya, Tatsuo, Shimizu, Toru, Shinomiya, Nariyoshi

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Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12 von Toyoda, Yu, Kawamura, Yusuke, Nakayama, Akiyoshi, Nakaoka, Hirofumi, Higashino, Toshihide, Shimizu, Seiko, Ooyama, Hiroshi, Morimoto, Keito, Uchida, Naohiro, Shigesawa, Ryuichiro, Takeuchi, Kenji, Inoue, Ituro, Ichida, Kimiyoshi, Suzuki, Hiroshi, Shinomiya, Nariyoshi, Takada, Tappei, Matsuo, Hirotaka

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Identification of a dysfunctional splicing mutation in the SLC22A12/URAT1 gene causing renal hypouricaemia type 1: a report on two families von Kawamura, Yusuke, Toyoda, Yu, Ohnishi, Takuma, Hisatomi, Ryutaro, Higashino, Toshihide, Nakayama, Akiyoshi, Shimizu, Seiko, Yanagi, Masato, Kamimaki, Isamu, Fujimaru, Rika, Suzuki, Hiroshi, Shinomiya, Nariyoshi, Takada, Tappei, Matsuo, Hirotaka

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Influence of respiration on cerebrospinal fluid movement using magnetic resonance spin labeling von Yamada, Shinya, Miyazaki, Mitsue, Yamashita, Yuichi, Ouyang, Cheng, Yui, Masao, Nakahashi, Masao, Shimizu, Seiko, Aoki, Ikuo, Morohoshi, Yukuo, McComb, James Gordon

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OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts von Toyoda, Yu, Kawamura, Yusuke, Nakayama, Akiyoshi, Morimoto, Keito, Shimizu, Seiko, Tanahashi, Yuki, Tamura, Takashi, Kondo, Takaaki, Kato, Yasufumi, Ichida, Kimiyoshi, Suzuki, Hiroshi, Shinomiya, Nariyoshi, Kobayashi, Yasushi, Takada, Tappei, Matsuo, Hirotaka

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The effects of URAT1/SLC22A12 nonfunctional variants,R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression von Sakiyama, Masayuki, Matsuo, Hirotaka, Shimizu, Seiko, Nakashima, Hiroshi, Nakamura, Takahiro, Nakayama, Akiyoshi, Higashino, Toshihide, Naito, Mariko, Suma, Shino, Hishida, Asahi, Satoh, Takahiro, Sakurai, Yutaka, Takada, Tappei, Ichida, Kimiyoshi, Ooyama, Hiroshi, Shimizu, Toru, Shinomiya, Nariyoshi

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A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility von Chang, Shun-Jen, Toyoda, Yu, Kawamura, Yusuke, Nakamura, Takahiro, Nakatochi, Masahiro, Nakayama, Akiyoshi, Liao, Wei-Ting, Shimizu, Seiko, Takada, Tappei, Takeuchi, Kenji, Wakai, Kenji, Shi, Yongyong, Shinomiya, Nariyoshi, Chen, Chung-Jen, Li, Changgui, Okada, Yukinori, Ichida, Kimiyoshi, Matsuo, Hirotaka

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The influence of a noisy environment on hearing impairment and tinnitus: The hearing outcomes of 50-year-old male Japan ground self-defense force personnel von Takihata, Saki, Mizutari, Kunio, Morita, Ichiro, Matsuo, Hirotaka, Nakayama, Akiyoshi, Shimizu, Seiko, Ueno, Miki, Ito, Toshimitsu, Shinomiya, Nariyoshi, Shiotani, Akihiro

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Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors von Nakayama, Akiyoshi, Matsuo, Hirotaka, Nakaoka, Hirofumi, Nakamura, Takahiro, Nakashima, Hiroshi, Takada, Yuzo, Oikawa, Yuji, Takada, Tappei, Sakiyama, Masayuki, Shimizu, Seiko, Kawamura, Yusuke, Chiba, Toshinori, Abe, Junko, Wakai, Kenji, Kawai, Sayo, Okada, Rieko, Tamura, Takashi, Shichijo, Yuka, Akashi, Airi, Suzuki, Hiroshi, Hosoya, Tatsuo, Sakurai, Yutaka, Ichida, Kimiyoshi, Shinomiya, Nariyoshi

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A Common Variant of Organic Anion Transporter 4 (OAT4/SLC22A11) Gene Is Associated with Renal Underexcretion Type Gout von Sakiyama, Masayuki, Matsuo, Hirotaka, Shimizu, Seiko, Nakashima, Hiroshi, Nakayama, Akiyoshi, Chiba, Toshinori, Naito, Mariko, Takada, Tappei, Suzuki, Hiroshi, Hamajima, Nobuyuki, Ichida, Kimiyoshi, Shimizu, Toru, Shinomiya, Nariyoshi

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Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population von Kawaguchi, Makoto, Nakayama, Akiyoshi, Aoyagi, Yuka, Nakamura, Takahiro, Shimizu, Seiko, Kawamura, Yusuke, Takao, Mikiya, Tamura, Takashi, Hishida, Asahi, Nagayoshi, Mako, Nagase, Mitsuo, Ooyama, Keiko, Ooyama, Hiroshi, Shinomiya, Nariyoshi, Matsuo, Hirotaka

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Characterizing Protein Concentration in Cerebrospinal Fluid with T2 Component Analysis von Koizumi, Tatsuya, Shimizu, Seiko, Akiba, Chihiro, Kakizoe, Hidenori, Bandai, Hideki, Sato, Kenichi, Nagasawa, Hidekazu, Ogino, Ikuko, Nakajima, Madoka, Yamada, Shinya, Oshio, Koichi, Miyajima, Masakazu

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Strong genetic effect on gout revealed by genetic risk score from meta-analysis of two genome-wide association studies von Nakayama, Akiyoshi, Kawamura, Yusuke, Nakatochi, Masahiro, Toyoda, Yu, Nakajima, Mayuko, Maehara, Kazuki, Kirihara, Mana, Shimizu, Seiko, Matsuo, Keitaro, Matsuo, Hirotaka

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Identification of novel gout loci from trans-ethnic meta-analysis of serum urate level von Kawamura, Yusuke, Nakayama, Akiyoshi, Nakatochi, Masahiro, Aoki, Yuka, Toyoda, Yu, Nakamura, Takahiro, Shimizu, Seiko, Matsuo, Keitaro, Shinomiya, Nariyoshi, Matsuo, Hirotaka

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Structural characterization of dimethyldithiodenafil and dimethylthiocarbodenafil, analogs of sildenafil von Sakamoto, Miho, Suzuki, Jin, Saito, Yuri, Shimizu, Seiko, Kobayashi, Kazue, Nagashima, Machiko, Moriyasu, Takako, Fukaya, Haruhiko, Saito, Koichi

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Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach von Ogura, Masatsune, Toyoda, Yu, Sakiyama, Masayuki, Kawamura, Yusuke, Nakayama, Akiyoshi, Yamanashi, Yoshihide, Takada, Tappei, Shimizu, Seiko, Higashino, Toshihide, Nakajima, Mayuko, Naito, Mariko, Hishida, Asahi, Kawai, Sayo, Okada, Rieko, Sasaki, Makoto, Ayaori, Makoto, Suzuki, Hiroshi, Takata, Koki, Ikewaki, Katsunori, Harada-Shiba, Mariko, Shinomiya, Nariyoshi, Matsuo, Hirotaka

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Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk von Sakiyama, Masayuki, Matsuo, Hirotaka, Akashi, Airi, Shimizu, Seiko, Higashino, Toshihide, Kawaguchi, Makoto, Nakayama, Akiyoshi, Naito, Mariko, Kawai, Sayo, Nakashima, Hiroshi, Sakurai, Yutaka, Ichida, Kimiyoshi, Shimizu, Toru, Ooyama, Hiroshi, Shinomiya, Nariyoshi

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