Chrono-Drug Discovery and Development Based on Circadian Rhythm of Molecular, Cellular and Organ Level von Ohdo, Shigehiro

Volltext

Chronotherapeutic strategy: Rhythm monitoring, manipulation and disruption von Ohdo, Shigehiro

Volltext

Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor von Matsunaga, Naoya, Ogino, Takashi, Hara, Yukinori, Tanaka, Takahiro, Koyanagi, Satoru, Ohdo, Shigehiro

Volltext

Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis von Yoshida, Yuya, Matsunaga, Naoya, Nakao, Takaharu, Hamamura, Kengo, Kondo, Hideaki, Ide, Tomomi, Tsutsui, Hiroyuki, Tsuruta, Akito, Kurogi, Masayuki, Nakaya, Michio, Kurose, Hitoshi, Koyanagi, Satoru, Ohdo, Shigehiro

Volltext

Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins von Tokunaga, Keisuke, Sato, Mami, Kuwata, Keiko, Miura, Chizuru, Fuchida, Hirokazu, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro, Shindo, Naoya, Ojida, Akio

Volltext

Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice von Tsuruta, Akito, Shiiba, Yuki, Matsunaga, Naoya, Fujimoto, Marina, Yoshida, Yuya, Koyanagi, Satoru, Ohdo, Shigehiro

Volltext

Chronopharmaceutics: Pharmaceutics Focused on Biological Rhythm von Ohdo, Shigehiro

Volltext

Chronopharmacology of immune-related diseases von Ohdo, Shigehiro, Koyanagi, Satoru, Matsunaga, Naoya

Volltext

Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice von Shiromizu, Shoya, Yamauchi, Tomoaki, Kusunose, Naoki, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

Volltext

Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells von Uchinomiya, Shohei, Matsunaga, Naoya, Kamoda, Koichiro, Kawagoe, Ryosuke, Tsuruta, Akito, Ohdo, Shigehiro, Ojida, Akio

Volltext

Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development von Koyanagi, Satoru, Kusunose, Naoki, Yasukochi, Sai, Ohdo, Shigehiro

Volltext

The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells von Jaballah, Nour, Tsurudome, Yuya, Murakami, Chiho, Matsunaga, Naoya, Ushijima, Kentaro, Koyanagi, Satoru, Ohdo, Shigehiro

Volltext

RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene von Omata, Yuji, Yamauchi, Tomoaki, Tsuruta, Akito, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

Volltext

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides von Shindo, Naoya, Fuchida, Hirokazu, Sato, Mami, Watari, Kosuke, Shibata, Tomohiro, Kuwata, Keiko, Miura, Chizuru, Okamoto, Kei, Hatsuyama, Yuji, Tokunaga, Keisuke, Sakamoto, Seiichi, Morimoto, Satoshi, Abe, Yoshito, Shiroishi, Mitsunori, Caaveiro, Jose M. M., Ueda, Tadashi, Tamura, Tomonori, Matsunaga, Naoya, Nakao, Takaharu, Koyanagi, Satoru, Ohdo, Shigehiro, Yamaguchi, Yasuchika, Hamachi, Itaru, Ono, Mayumi, Ojida, Akio

Volltext

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia von Koyanagi, Satoru, Kusunose, Naoki, Taniguchi, Marie, Akamine, Takahiro, Kanado, Yuki, Ozono, Yui, Masuda, Takahiro, Kohro, Yuta, Matsunaga, Naoya, Tsuda, Makoto, Salter, Michael W., Inoue, Kazuhide, Ohdo, Shigehiro

Volltext

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats von TSUDA, Makoto, KOHRO, Yuta, INOUE, Kazuhide, YANO, Takayuki, TSUJIKAWA, Tomoko, KITANO, Junko, TOZAKI-SAITOH, Hidetoshi, KOYANAGI, Satoru, OHDO, Shigehiro, JI, Ru-Rong, SALTER, Michael W

Volltext

Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity von Kato, Mizuki, Tsurudome, Yuya, Kanemitsu, Takumi, Yasukochi, Sai, Kanado, Yuki, Ogino, Takashi, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro

Volltext

Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells von Ogino, Takashi, Matsunaga, Naoya, Tanaka, Takahiro, Tanihara, Tomohito, Terajima, Hideki, Yoshitane, Hikari, Fukada, Yoshitaka, Tsuruta, Akito, Koyanagi, Satoru, Ohdo, Shigehiro

Volltext

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease von Hirose, Yuya, Shindo, Naoya, Mori, Makiko, Onitsuka, Satsuki, Isogai, Hikaru, Hamada, Rui, Hiramoto, Tadanari, Ochi, Jinta, Takahashi, Daisuke, Ueda, Tadashi, Caaveiro, Jose M. M., Yoshida, Yuya, Ohdo, Shigehiro, Matsunaga, Naoya, Toba, Shinsuke, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Sato, Akihiko, Kawanishi, Eiji, Ojida, Akio

Volltext

Chronopharmacology Focused on Biological Clock von Ohdo, Shigehiro

Volltext