Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli von Cavanaugh, Daniel J, Lee, Hyosang, Lo, Liching, Shields, Shannon D, Zylka, Mark J, Basbaum, Allan I, Anderson, David J

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Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma von Reese, Rebecca M., Dourado, Michelle, Anderson, Keith, Warming, Søren, Stark, Kimberly L., Balestrini, Alessia, Suto, Eric, Lee, Wyne, Riol-Blanco, Lorena, Shields, Shannon D., Hackos, David H.

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Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors von Shields, Shannon D, Deng, Lunbin, Reese, Rebecca M, Dourado, Michelle, Tao, Janet, Foreman, Oded, Chang, Jae H, Hackos, David H

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A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel von Liu, Chang, Reese, Rebecca, Vu, Simon, Rougé, Lionel, Shields, Shannon D., Kakiuchi-Kiyota, Satoko, Chen, Huifen, Johnson, Kevin, Shi, Yu Patrick, Chernov-Rogan, Tania, Greiner, Demi Maria Zabala, Kohli, Pawan Bir, Hackos, David, Brillantes, Bobby, Tam, Christine, Li, Tianbo, Wang, Jianyong, Safina, Brian, Magnuson, Steve, Volgraf, Matthew, Payandeh, Jian, Zheng, Jie, Rohou, Alexis, Chen, Jun

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Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors von Shields, Shannon D., Cavanaugh, Daniel J., Lee, Hyosang, Anderson, David J., Basbaum, Allan I.

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Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids von Deng, Lunbin, Dourado, Michelle, Reese, Rebecca M., Huang, Kevin, Shields, Shannon D., Stark, Kimberly L., Maksymetz, James, Lin, Han, Kaminker, Joshua S., Jung, Min, Foreman, Oded, Tao, Janet, Ngu, Hai, Joseph, Victory, Roose-Girma, Meron, Tam, Lucinda, Lardell, Susanne, Orrhult, Linnea Strid, Karila, Paul, Allard, Julien, Hackos, David H.

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A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment von Balestrini, Alessia, Joseph, Victory, Dourado, Michelle, Reese, Rebecca M., Shields, Shannon D., Rouge, Lionel, Bravo, Daniel D., Chernov-Rogan, Tania, Austin, Cary D., Chen, Huifen, Wang, Lan, Villemure, Elisia, Shore, Daniel G. M., Verma, Vishal A., Hu, Baihua, Chen, Yong, Leong, Laurie, Bjornson, Chris, Hotel, Kathy, Gogineni, Alvin, Lee, Wyne P., Suto, Eric, Wu, Xiumin, Liu, John, Zhang, Juan, Gandham, Vineela, Wang, Jianyong, Payandeh, Jian, Ciferri, Claudio, Estevez, Alberto, Arthur, Christopher P., Kortmann, Jens, Wong, Ryan L., Heredia, Jose E., Doerr, Jonas, Jung, Min, Vander Heiden, Jason A., Roose-Girma, Merone, Tam, Lucinda, Barck, Kai H., Carano, Richard A. D., Ding, Han Ting, Brillantes, Bobby, Tam, Christine, Yang, Xiaoying, Gao, Simon S., Ly, Justin Q., Liu, Liling, Chen, Liuxi, Liederer, Bianca M., Lin, Joseph H., Magnuson, Steven, Chen, Jun, Hackos, David H., Elstrott, Justin, Rohou, Alexis, Safina, Brian S., Volgraf, Matthew, Bauer, Rebecca N., Riol-Blanco, Lorena

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Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury von Shields, Shannon D, Cheng, Xiaoyang, Uçeyler, Nurcan, Sommer, Claudia, Dib-Hajj, Sulayman D, Waxman, Stephen G

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Conditional deletion of HCN2 from primary afferents uncovers the heterogeneity of inflammatory hypersensitivity von Shields, Shannon D.

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Oral administration of PF-01247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis von Shields, Shannon D, Butt, Richard P, Dib-Hajj, Sulayman D, Waxman, Stephen G

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Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury von González-Fernández, Carlos, Fernández-Martos, Carmen María, Shields, Shannon D, Arenas, Ernest, Javier Rodríguez, Francisco

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Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease von Terrett, Jack A., Ly, Justin Q., Katavolos, Paula, Hasselgren, Catrin, Laing, Steven, Zhong, Fiona, Villemure, Elisia, Déry, Martin, Larouche-Gauthier, Robin, Chen, Huifen, Shore, Daniel G., Lee, Wyne P., Suto, Eric, Johnson, Kevin, Brooks, Marjory, Stablein, Alyssa, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Elstrott, Justin, Gandham, Vineela, Joseph, Victory, Booler, Helen, Cain, Gary, Chou, Carolina, Fullerton, Aaron, Lepherd, Michelle, Stainton, Shannon, Torres, Elizabeth, Urban, Konnie, Yu, Lanlan, Zhong, Yu, Bao, Linda, Chou, Kang-Jye, Lin, Jessica, Zhang, Wei, La, Hank, Liu, Liling, Mulder, Teresa, Chen, Jun, Chernov-Rogan, Tania, Johnson, Adam R., Hackos, David H., Leahey, Rebecca, Shields, Shannon D., Balestrini, Alessia, Riol-Blanco, Lorena, Safina, Brian S., Volgraf, Matthew, Magnuson, Steven, Kakiuchi-Kiyota, Satoko

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Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic E... von Terrett, Jack A, Chen, Huifen, Shore, Daniel G, Villemure, Elisia, Larouche-Gauthier, Robin, Déry, Martin, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Lu, Aijun, Wang, Yunli, Cridland, Andrew P, Ward, Stuart I, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Balestrini, Alessia, Riol-Blanco, Lorena, Lee, Wyne P, Liu, John, Suto, Eric, Wu, Xiumin, Zhang, Juan, Ly, Justin Q, La, Hank, Johnson, Kevin, Baumgardner, Matt, Chou, Kang-Jye, Rohou, Alexis, Rougé, Lionel, Safina, Brian S, Magnuson, Steven, Volgraf, Matthew

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Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310 von Safina, Brian S, McKerrall, Steven J, Sun, Shaoyi, Chen, Chien-An, Chowdhury, Sultan, Jia, Qi, Li, Jun, Zenova, Alla Y, Andrez, Jean-Christophe, Bankar, Girish, Bergeron, Philippe, Chang, Jae H, Chang, Elaine, Chen, Jun, Dean, Richard, Decker, Shannon M, DiPasquale, Antonio, Focken, Thilo, Hemeon, Ivan, Khakh, Kuldip, Kim, Amy, Kwan, Rainbow, Lindgren, Andrea, Lin, Sophia, Maher, Jonathan, Mezeyova, Janette, Misner, Dinah, Nelkenbrecher, Karen, Pang, Jodie, Reese, Rebecca, Shields, Shannon D, Sojo, Luis, Sheng, Tao, Verschoof, Henry, Waldbrook, Matthew, Wilson, Michael S, Xie, Zhiwei, Young, Clint, Zabka, Tanja S, Hackos, David H, Ortwine, Daniel F, White, Andrew D, Johnson, J.P, Robinette, C. Lee, Dehnhardt, Christoph M, Cohen, Charles J, Sutherlin, Daniel P

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Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons von Shields, Shannon D., Mazario, Javier, Skinner, Kate, Basbaum, Allan I.

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Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain von McKerrall, Steven J, Nguyen, Teresa, Lai, Kwong Wah, Bergeron, Philippe, Deng, Lunbin, DiPasquale, Antonio, Chang, Jae H, Chen, Jun, Chernov-Rogan, Tania, Hackos, David H, Maher, Jonathan, Ortwine, Daniel F, Pang, Jodie, Payandeh, Jian, Proctor, William R, Shields, Shannon D, Vogt, Jennifer, Ji, Pengfei, Liu, Wenfeng, Ballini, Elisa, Schumann, Lilia, Tarozzo, Glauco, Bankar, Girish, Chowdhury, Sultan, Hasan, Abid, Johnson, J. P, Khakh, Kuldip, Lin, Sophia, Cohen, Charles J, Dehnhardt, Christoph M, Safina, Brian S, Sutherlin, Daniel P

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A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists von Villemure, Elisia, Terrett, Jack A, Larouche-Gauthier, Robin, Déry, Martin, Chen, Huifen, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Magnuson, Steven, Volgraf, Matthew

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Discovery of a Potent (4R,5S)‑4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modelin... von Chen, Huifen, Volgraf, Matthew, Do, Steven, Kolesnikov, Aleksandr, Shore, Daniel G, Verma, Vishal A, Villemure, Elisia, Wang, Lan, Chen, Yong, Hu, Baihua, Lu, Ai-Jun, Wu, Guosheng, Xu, Xiaofeng, Yuen, Po-wai, Zhang, Yamin, Erickson, Shawn D, Dahl, Martin, Brotherton-Pleiss, Christine, Tay, Suzanne, Ly, Justin Q, Murray, Lesley J, Chen, Jun, Amm, Desiree, Lange, Wienke, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Lyssikatos, Joseph P, Safina, Brian S, Estrada, Anthony A

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Discovery of Acyl-sulfonamide Na v 1.7 Inhibitors GDC-0276 and GDC-0310 von Safina, Brian S, McKerrall, Steven J, Sun, Shaoyi, Chen, Chien-An, Chowdhury, Sultan, Jia, Qi, Li, Jun, Zenova, Alla Y, Andrez, Jean-Christophe, Bankar, Girish, Bergeron, Philippe, Chang, Jae H, Chang, Elaine, Chen, Jun, Dean, Richard, Decker, Shannon M, DiPasquale, Antonio, Focken, Thilo, Hemeon, Ivan, Khakh, Kuldip, Kim, Amy, Kwan, Rainbow, Lindgren, Andrea, Lin, Sophia, Maher, Jonathan, Mezeyova, Janette, Misner, Dinah, Nelkenbrecher, Karen, Pang, Jodie, Reese, Rebecca, Shields, Shannon D, Sojo, Luis, Sheng, Tao, Verschoof, Henry, Waldbrook, Matthew, Wilson, Michael S, Xie, Zhiwei, Young, Clint, Zabka, Tanja S, Hackos, David H, Ortwine, Daniel F, White, Andrew D, Johnson, Jr, J P, Robinette, C Lee, Dehnhardt, Christoph M, Cohen, Charles J, Sutherlin, Daniel P

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Bradykinin and nerve growth factor release the capsaicin receptor from Ptdins(4,5)P2-mediated inhibition von CHUANG, Huai-Hu, PRESCOTT, Elizabeth D, HAEYOUNG KONG, SHIELDS, Shannon, JORDT, Sven-Eric, BASBAUM, Allan I, CHAO, Moses V, JULIUS, David

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