MicroRNA‐34a‐5p Promotes Joint Destruction During Osteoarthritis von Endisha, Helal, Datta, Poulami, Sharma, Anirudh, Nakamura, Sayaka, Rossomacha, Evgeny, Younan, Carolen, Ali, Shabana A., Tavallaee, Ghazaleh, Lively, Starlee, Potla, Pratibha, Shestopaloff, Konstantin, Rockel, Jason S., Krawetz, Roman, Mahomed, Nizar N., Jurisica, Igor, Gandhi, Rajiv, Kapoor, Mohit

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DCMD: Distance-based classification using mixture distributions on microbiome data von Shestopaloff, Konstantin, Dong, Mei, Gao, Fan, Xu, Wei

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Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation von Chahal, Jaskarndip, Gómez‐Aristizábal, Alejandro, Shestopaloff, Konstantin, Bhatt, Shashank, Chaboureau, Amélie, Fazio, Antonietta, Chisholm, Jolene, Weston, Amanda, Chiovitti, Julia, Keating, Armand, Kapoor, Mohit, Ogilvie‐Harris, Darrell J., Syed, Khalid A., Gandhi, Rajiv, Mahomed, Nizar N., Marshall, Kenneth W., Sussman, Marshall S., Naraghi, Ali M., Viswanathan, Sowmya

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Estimating total species using a weighted combination of expected mixture distribution component counts von Shestopaloff, Konstantin, Xu, Wei, Escobar, Michael D.

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A classification modeling approach for determining metabolite signatures in osteoarthritis von Rockel, Jason S, Zhang, Weidong, Shestopaloff, Konstantin, Likhodii, Sergei, Sun, Guang, Furey, Andrew, Randell, Edward, Sundararajan, Kala, Gandhi, Rajiv, Zhai, Guangju, Kapoor, Mohit

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Investigating Molecular Signatures Underlying Trapeziometacarpal Osteoarthritis Through the Evaluation of Systemic Cytokine Expression von Ratneswaran, Anusha, Rockel, Jason S, Antflek, Daniel, Matelski, John J, Shestopaloff, Konstantin, Kapoor, Mohit, Baltzer, Heather

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Abstract 138: Cytokine Expression In Trapeziometacarpal Osteoarthritis: Predicting Prognosis, Progression And Treatment von Baltzer, Heather L., Ratneswaran, Anusha, Antflek, Daniel, Rockel, Jason, Shestopaloff, Konstantin, Kapoor, Mohit

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Effect of autotaxin inhibition in a surgically-induced mouse model of osteoarthritis von Datta, Poulami, Gandhi, Rajiv, Nakamura, Sayaka, Lively, Starlee, Rossomacha, Evgeny, Potla, Pratibha, Shestopaloff, Konstantin, Endisha, Helal, Pastrello, Chiara, Jurisica, Igor, Rockel, Jason S., Kapoor, Mohit

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Analyzing differences between microbiome communities using mixture distributions von Shestopaloff, Konstantin, Escobar, Michael D., Xu, Wei

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Association of host genome with intestinal microbial composition in a large healthy cohort von Turpin, Williams, Espin-Garcia, Osvaldo, Xu, Wei, Silverberg, Mark S, Kevans, David, Smith, Michelle I, Guttman, David S, Griffiths, Anne, Panaccione, Remo, Otley, Anthony, Xu, Lizhen, Shestopaloff, Konstantin, Moreno-Hagelsieb, Gabriel, Paterson, Andrew D, Croitoru, Kenneth

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Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background von Zhang, Cong, Shestopaloff, Konstantin, Hollis, Benjamin, Kwok, Chun Hei, Hon, Claudia, Hartmann, Nicole, Tian, Chengeng, Wozniak, Magdalena, Santos, Luis, West, Dominique, Gardiner, Stephen, Mallon, Ann-Marie, Readie, Aimee, Martin, Ruvie, Nichols, Thomas, Beste, Michael T., Zierer, Jonas, Ferrero, Enrico, Vandemeulebroecke, Marc, Jostins-Dean, Luke

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Determinants of Intestinal Permeability in Healthy First-Degree Relatives of Individuals with Crohn's Disease von Kevans, David, Turpin, Williams, Madsen, Karen, Meddings, Jon, Shestopaloff, Konstantin, Xu, Wei, Moreno-Hagelsieb, Gabriel, Griffiths, Anne, Silverberg, Mark S., Paterson, Andrew, Croitoru, Kenneth

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Mo1107 THE GEM PROJECT: CROHN'S DISEASE POLYGENIC RISK SCORE IS ASSOCIATED WITH PRECLINICAL INFLAMMATION IN ASYMPTOMATIC FIRST-DEGREE RELATIVES OF CROHN'S DISEASE PATIENTS von Lee, Sun-Ho, Shestopaloff, Konstantin, Espin-Garcia, Osvaldo, Turpin, Williams, Garay, Juan Antonio Raygoza, Power, Namita, Smith, Michelle I., Silverberg, Mark S., Xu, Wei, Paterson, Andrew, Croitoru, Kenneth

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FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects von Turpin, Williams, Bedrani, Larbi, Espin-Garcia, Osvaldo, Xu, Wei, Silverberg, Mark S., Smith, Michelle I., Guttman, David S., Griffiths, Anne, Moayyedi, Paul, Panaccione, Remo, Huynh, Hien, Steinhart, Hillary, Aumais, Guy, Shestopaloff, Konstantin, Dieleman, Levinus A., Turner, Dan, Paterson, Andrew D., Croitoru, Kenneth

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A model for estimating ovarian cancer risk: Application for preventive oophorectomy von Giannakeas, Vasily, Sopik, Victoria, Shestopaloff, Konstantin, Iqbal, Javaid, Rosen, Barry, Akbari, Mohammad, Narod, Steven A

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86 Association of Environmental Exposures With the Composition and Diversity of the Human Gut Microbiome in Healthy First Degree Relatives (FDR) of Crohn's Patients von Turpin, Williams, Kelly, Orlaith, Shestopaloff, Konstantin, Espin-Garcia, Osvaldo, Silverberg, Mark S, Smith, Michelle I, Xu, Wei, Guttman, David S, Paterson, Andrew, Croitoru, Kenneth

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Su1900 Association of Functional Capacity of Fecal Microbiota With Intestinal Permeability in Healthy First Degree Relatives of Crohn's Disease Patients von Turpin, Williams, Kevans, David, Shestopaloff, Konstantin, Smith, Michelle I, Guttman, David S, Silverberg, Mark S, Xu, Wei, Paterson, Andrew, Croitoru, Kenneth

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A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer von Xu, Wei, Green, Roger, Green, Jane, Dicks, Elizabeth, Shestopaloff, Konstantin, Werdyani, Salem, Xu, Jingxiong, Savas, Sevtap, Parfrey, Patrick

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Germline INDELs and CNVs in a cohort of colorectal cancer patients: their characteristics, associations with relapse‐free survival time, and potential time‐varying effects on the r... von Werdyani, Salem, Yu, Yajun, Skardasi, Georgia, Xu, Jingxiong, Shestopaloff, Konstantin, Xu, Wei, Dicks, Elizabeth, Green, Jane, Parfrey, Patrick, Yilmaz, Yildiz E., Savas, Sevtap

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A genome wide association study on Newfoundland colorectal cancer patients' survival outcomes von Xu, Wei, Xu, Jingxiong, Shestopaloff, Konstantin, Dicks, Elizabeth, Green, Jane, Parfrey, Patrick, Green, Roger, Savas, Sevtap

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