Predictable and precise template-free CRISPR editing of pathogenic variants von Shen, Max W., Arbab, Mandana, Hsu, Jonathan Y., Worstell, Daniel, Culbertson, Sannie J., Krabbe, Olga, Cassa, Christopher A., Liu, David R., Gifford, David K., Sherwood, Richard I.

Volltext

Using CRISPR to understand and manipulate gene regulation von Akinci, Ersin, Hamilton, Marisa C., Khowpinitchai, Benyapa, Sherwood, Richard

Volltext

Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape von Sherwood, Richard I, Hashimoto, Tatsunori, O'Donnell, Charles W, Lewis, Sophia, Barkal, Amira A, van Hoff, John Peter, Karun, Vivek, Jaakkola, Tommi, Gifford, David K

Volltext

Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency von Bermudez-Cabrera, Heysol C., Culbertson, Sannie, Barkal, Sammy, Holmes, Benjamin, Shen, Max W., Zhang, Sophia, Gifford, David K., Sherwood, Richard I.

Volltext

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer von Betancur, Paola A., Abraham, Brian J., Yiu, Ying Y., Willingham, Stephen B., Khameneh, Farnaz, Zarnegar, Mark, Kuo, Angera H., McKenna, Kelly, Kojima, Yoko, Leeper, Nicholas J., Ho, Po, Gip, Phung, Swigut, Tomek, Sherwood, Richard I., Clarke, Michael F., Somlo, George, Young, Richard A., Weissman, Irving L.

Volltext

A Multiplexed Barcodelet Single-Cell RNA-Seq Approach Elucidates Combinatorial Signaling Pathways that Drive ESC Differentiation von Yeo, Grace Hui Ting, Lin, Lin, Qi, Celine Yueyue, Cha, Minsun, Gifford, David K., Sherwood, Richard I.

Volltext

Peptide fusion improves prime editing efficiency von Velimirovic, Minja, Zanetti, Larissa C., Shen, Max W., Fife, James D., Lin, Lin, Cha, Minsun, Akinci, Ersin, Barnum, Danielle, Yu, Tian, Sherwood, Richard I.

Volltext

An integrated model of multiple-condition ChIP-Seq data reveals predeterminants of Cdx2 binding von Mahony, Shaun, Edwards, Matthew D, Mazzoni, Esteban O, Sherwood, Richard I, Kakumanu, Akshay, Morrison, Carolyn A, Wichterle, Hynek, Gifford, David K

Volltext

Machine learning based CRISPR gRNA design for therapeutic exon skipping von Louie, Wilson, Shen, Max W., Tahiry, Zakir, Zhang, Sophia, Worstell, Daniel, Cassa, Christopher A., Sherwood, Richard I., Gifford, David K.

Volltext

Cas9 Functionally Opens Chromatin von Barkal, Amira A, Srinivasan, Sharanya, Hashimoto, Tatsunori, Gifford, David K, Sherwood, Richard I

Volltext

Comprehensive Mapping of Key Regulatory Networks that Drive Oncogene Expression von Lin, Lin, Holmes, Benjamin, Shen, Max W., Kammeron, Darnell, Geijsen, Niels, Gifford, David K., Sherwood, Richard I.

Volltext

High-throughput mapping of regulatory DNA von Rajagopal, Nisha, Srinivasan, Sharanya, Kooshesh, Kameron, Guo, Yuchun, Edwards, Matthew D, Banerjee, Budhaditya, Syed, Tahin, Emons, Bart J M, Gifford, David K, Sherwood, Richard I

Volltext

Identification of determinants of differential chromatin accessibility through a massively parallel genome-integrated reporter assay von Hammelman, Jennifer, Krismer, Konstantin, Banerjee, Budhaditya, Gifford, David K., Sherwood, Richard I.

Volltext

Detection of gene cis-regulatory element perturbations in single-cell transcriptomes von Yeo, Grace Hui Ting, Juez, Oscar, Chen, Qing, Banerjee, Budhaditya, Chu, Lendy, Shen, Max W., Sabry, May, Logister, Ive, Sherwood, Richard I., Gifford, David K.

Volltext

Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells von Wagers, Amy J., Sherwood, Richard I., Christensen, Julie L., Weissman, Irving L.

Volltext

Gata6 potently initiates reprograming of pluripotent and differentiated cells to extraembryonic endoderm stem cells von Wamaitha, Sissy E, del Valle, Ignacio, Cho, Lily T Y, Wei, Yingying, Fogarty, Norah M E, Blakeley, Paul, Sherwood, Richard I, Ji, Hongkai, Niakan, Kathy K

Volltext

Cloning-free CRISPR von Arbab, Mandana, Srinivasan, Sharanya, Hashimoto, Tatsunori, Geijsen, Niels, Sherwood, Richard I.

Volltext

Early Maturity as the New Normal: A Century-long Study of Bone Age von Boeyer, Melanie E, Sherwood, Richard J, Deroche, Chelsea B, Duren, Dana L

Volltext

Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs von Mou, Hongmei, Zhao, Rui, Sherwood, Richard, Ahfeldt, Tim, Lapey, Allen, Wain, John, Sicilian, Leonard, Izvolsky, Konstantin, Lau, Frank H., Musunuru, Kiran, Cowan, Chad, Rajagopal, Jayaraj

Volltext

Age-related changes in spatiotemporal characteristics of gait accompany ongoing lower limb linear growth in late childhood and early adolescence von Froehle, Andrew W, Nahhas, Ramzi W, Sherwood, Richard J, Duren, Dana L

Volltext