Structure–Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens von Hu, Ziwei, Leus, Inga V., Chandar, Brinda, Sherborne, Bradley S., Avila, Quentin P., Rybenkov, Valentin V., Zgurskaya, Helen I., Duerfeldt, Adam S.

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Design and synthesis of a library of C8-substituted sulfamidoadenosines to probe bacterial permeability von Yildirim, Okan, Barman, Dipti, Chung, Mia, Stone, Samantha, Geißen, Raphael, Boby, Melissa L., Sherborne, Bradley S., Tan, Derek S.

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Correction to “Structure–Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens” von Hu, Ziwei, Leus, Inga V., Chandar, Brinda, Sherborne, Bradley S., Avila, Quentin P., Rybenkov, Valentin V., Zgurskaya, Helen I., Duerfeldt, Adam S.

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40 von Lu, Jun, Byrne, Noel, Wang, John, Bricogne, Gerard, Brown, Frank K, Chobanian, Harry R, Colletti, Steven L, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Guo, Yan, Hall, Dawn L, Hadix, Jennifer, Hastings, Nicholas B, Hermes, Jeffrey D, Ho, Thu, Howard, Andrew D, Josien, Hubert, Kornienko, Maria, Lumb, Kevin J, Miller, Michael W, Patel, Sangita B, Pio, Barbara, Plummer, Christopher W, Sherborne, Bradley S, Sheth, Payal, Souza, Sarah, Tummala, Srivanya, Vonrhein, Clemens, Webb, Maria, Allen, Samantha J, Johnston, Jennifer M, Weinglass, Adam B, Sharma, Sujata, Soisson, Stephen M

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Design and synthesis of a library of C2-substituted sulfamidoadenosines to probe bacterial permeability von Zhao, Shibin, Maceren, Julian, Chung, Mia, Stone, Samantha, Geißen, Raphael, Boby, Melissa L., Sherborne, Bradley S., Tan, Derek S.

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Molecular Simulations Identify Binding Poses and Approximate Affinities of Stapled α‑Helical Peptides to MDM2 and MDMX von Morrone, Joseph A, Perez, Alberto, Deng, Qiaolin, Ha, Sookhee N, Holloway, M. Katharine, Sawyer, Tomi K, Sherborne, Bradley S, Brown, Frank K, Dill, Ken A

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The evolution of drug design at Merck Research Laboratories von Brown, Frank K., Sherer, Edward C., Johnson, Scott A., Holloway, M. Katharine, Sherborne, Bradley S.

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Estimating the affinity of protein–ligand complex from changes to the charge-state distribution of a protein in electrospray ionization mass spectrometry von Blackburn, Elizabeth A., Maclean, John K.F., Sherborne, Bradley S., Walkinshaw, Malcolm D.

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Antagonists of the orexin receptors von Cai, Jiaqiang, Cooke, Fiona E, Sherborne, Bradley S

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Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening von Pickett, Stephen D, Sherborne, Bradley S, Wilkinson, Trevor, Bennett, James, Borkakoti, Neera, Broadhurst, Michael, Hurst, David, Kilford, Ian, McKinnell, Murray, Jones, Philip S

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Molecular Simulations Identify Binding Poses and Approximate Affinities of Stapled [alpha]-Helical Peptides to MDM2 and MDMX von Morrone, Joseph A, Perez, Alberto, Deng, Qiaolin, Ha, Sookhee N, Holloway, M Katharine, Sawyer, Tomi K, Sherborne, Bradley S, Brown, Frank K, Dill, Ken A

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Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator von Thomson, Christopher G., Aicher, Thomas D., Cheng, Weiwei, Du, Hongwen, Dudgeon, Crissy, Li, An-Hu, Li, Baozhong, Lightcap, Eric, Luo, Diheng, Mulvihill, Mark, Pan, Pengwei, Rahemtulla, Benjamin F., Rigby, Alan C., Sherborne, Bradley, Sood, Sanjeev, Surguladze, David, Talbot, Eric P. A., Tameire, Feven, Taylor, Simon, Wang, Yi, Wojnarowicz, Paulina, Xiao, Fenfen, Ramurthy, Savithri

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Collaborating to improve the use of free-energy and other quantitative methods in drug discovery von Sherborne, Bradley, Shanmugasundaram, Veerabahu, Cheng, Alan C., Christ, Clara D., DesJarlais, Renee L., Duca, Jose S., Lewis, Richard A., Loughney, Deborah A., Manas, Eric S., McGaughey, Georgia B., Peishoff, Catherine E., van Vlijmen, Herman

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Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology von Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Yao, Xin, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Hruza, Alan, Buevich, Alexei, Zhang, Li-Kang, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert

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MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology von Boga, Sobhana Babu, Deng, Yongqi, Zhu, Liang, Nan, Yang, Cooper, Alan B., Shipps, Gerald W., Doll, Ronald, Shih, Neng-Yang, Zhu, Hugh, Sun, Robert, Wang, Tong, Paliwal, Sunil, Tsui, Hon-Chung, Gao, Xiaolei, Yao, Xin, Desai, Jagdish, Wang, James, Alhassan, Abdul Basit, Kelly, Joseph, Patel, Mehul, Muppalla, Kiran, Gudipati, Subrahmanyam, Zhang, Li-Kang, Buevich, Alexei, Hesk, David, Carr, Donna, Dayananth, Priya, Black, Stuart, Mei, Hong, Cox, Kathleen, Sherborne, Bradley, Hruza, Alan W., Xiao, Li, Jin, Weihong, Long, Brian, Liu, Gongjie, Taylor, Stacey A., Kirschmeier, Paul, Windsor, William T., Bishop, Robert, Samatar, Ahmed A.

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Structure-based drug design of clinical compound MK-8353, a novel inhibitor of ERK von Hruza, Alan, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Buevich, Alexei, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert

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GCN2 조정 화합물 및 그의 용도 von SHERBORNE BRADLEY, THOMSON CHRISTOPHER G, RAHEMTULLA BENJAMIN, TALBOT ERIC P. A, MULVIHILL MARK J, RAMURTHY SAVITHRI

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ENL/AF9 YEATS의 C-연결된 억제제 von SHERBORNE BRADLEY, LADDUWAHETTY TAMMY, KHAN TANWEER A, HUGGINS DAVID JOHN, DEGORCE SEBASTIEN L, VACCA JOSEPH P, LIVERTON NIGEL

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GCN2 MODULATING COMPOUNDS AND USES THEREOF von Mulvihill, Mark J, Thomson, Christopher G, Ramurthy, Savithri, Rahemtulla, Benjamin, Sherborne, Bradley, Talbot, Eric P.A

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GCN2 MODULATING COMPOUNDS AND USES THEREOF von Mulvihill, Mark J, Thomson, Christopher G, Rahemtulla, Benjamin, Sherborne, Bradley, Talbot, Eric P.A, Ramurthy, Savithiri

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