Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening von Prakash, Ohm, Führing, Jana, Post, John, Shepherd, Sharon M, Eadsforth, Thomas C, Gray, David, Fedorov, Roman, Routier, Françoise H

Volltext

Crystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa: Comparison of Native and Antibiotic-Bound Forms von Sainsbury, Sarah, Bird, Louise, Rao, Vincenzo, Shepherd, Sharon M., Stuart, David I., Hunter, William N., Owens, Raymond J., Ren, Jingshan

Volltext

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention von Summers, Robert L., Pasaje, Charisse Flerida A., Pisco, Joao P., Striepen, Josefine, Luth, Madeline R., Kumpornsin, Krittikorn, Carpenter, Emma F., Munro, Justin T., Lin, De, Plater, Andrew, Punekar, Avinash S., Shepherd, Andrew M., Shepherd, Sharon M., Vanaerschot, Manu, Murithi, James M., Rubiano, Kelly, Akidil, Aslı, Ottilie, Sabine, Mittal, Nimisha, Dilmore, A. Hazel, Won, Madalyn, Mandt, Rebecca E.K., McGowen, Kerry, Owen, Edward, Walpole, Chris, Llinás, Manuel, Lee, Marcus C.S., Winzeler, Elizabeth A., Fidock, David A., Gilbert, Ian H., Wirth, Dyann F., Niles, Jacquin C., Baragaña, Beatriz, Lukens, Amanda K.

Volltext

Pseudomonas aeruginosa 4-amino-4-deoxychorismate lyase: spatial conservation of an active site tyrosine and classification of two types of enzyme von O'Rourke, Patrick E F, Eadsforth, Thomas C, Fyfe, Paul K, Shepherd, Sharon M, Hunter, William N

Volltext

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay von Zmuda, Filip, Sastry, Lalitha, Shepherd, Sharon M, Jones, Deuan, Scott, Alison, Craggs, Peter D, Cortes, Alvaro, Gray, David W, Torrie, Leah S, De Rycker, Manu

Volltext

Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment von Zmuda, Filip, Shepherd, Sharon M, Ferguson, Michael A J, Gray, David W, Torrie, Leah S, De Rycker, Manu

Volltext

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs von Green, Simon R., Davis, Susan H., Damerow, Sebastian, Engelhart, Curtis A., Mathieson, Michael, Baragaña, Beatriz, Robinson, David A., Tamjar, Jevgenia, Dawson, Alice, Tamaki, Fabio K., Buchanan, Kirsteen I., Post, John, Dowers, Karen, Shepherd, Sharon M., Jansen, Chimed, Zuccotto, Fabio, Gilbert, Ian H., Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Osuna-Cabello, Maria, Pérez-Herrán, Esther, Rebollo, María José, Guijarro López, Laura, Casado Castro, Patricia, Camino, Isabel, Kim, Heather C., Bean, James M., Nahiyaan, Navid, Rhee, Kyu Y., Wang, Qinglan, Tan, Vee Y., Boshoff, Helena I. M., Converse, Paul J., Li, Si-Yang, Chang, Yong S., Fotouhi, Nader, Upton, Anna M., Nuermberger, Eric L., Schnappinger, Dirk, Read, Kevin D., Encinas, Lourdes, Bates, Robert H., Wyatt, Paul G., Cleghorn, Laura A. T.

Volltext

GlcNAcstatin:  a Picomolar, Selective O-GlcNAcase Inhibitor That Modulates Intracellular O-GlcNAcylation Levels von Dorfmueller, Helge C, Borodkin, Vladimir S, Schimpl, Marianne, Shepherd, Sharon M, Shpiro, Natalia A, van Aalten, Daan M. F

Volltext

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase von Milne, Rachel, Wiedemar, Natalie, Corpas-Lopez, Victoriano, Moynihan, Eoin, Wall, Richard J., Dawson, Alice, Robinson, David A., Shepherd, Sharon M., Smith, Robert J., Hallyburton, Irene, Post, John M., Dowers, Karen, Torrie, Leah S., Gilbert, Ian H., Baragaña, Beatriz, Patterson, Stephen, Wyllie, Susan

Volltext

Structural insights into mechanism and specificity of O-GlcNAc transferase von Clarke, Andrew J, Hurtado-Guerrero, Ramon, Pathak, Shalini, Schüttelkopf, Alexander W, Borodkin, Vladimir, Shepherd, Sharon M, Ibrahim, Adel F M, van Aalten, Daan M F

Volltext

The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system von Rao, Vincenzo A., Shepherd, Sharon M., English, Grant, Coulthurst, Sarah J., Hunter, William N.

Volltext

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase von Torrie, Leah S, Robinson, David A, Thomas, Michael G, Hobrath, Judith V, Shepherd, Sharon M, Post, John M, Ko, Eun-Jung, Ferreira, Rafael Alves, Mackenzie, Claire J, Wrobel, Karolina, Edwards, Darren P, Gilbert, Ian H, Gray, David W, Fairlamb, Alan H, De Rycker, Manu

Volltext

Structure of Pseudomonas aeruginosa inosine 5′-monophosphate dehydrogenase von Rao, Vincenzo A., Shepherd, Sharon M., Owen, Richard, Hunter, William N.

Volltext

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis von Baragan˜a, Beatriz, Forte, Barbara, Choi, Ryan, Hewitt, Stephen Nakazawa, Bueren-Calabuig, Juan A., Pisco, Joa˜o Pedro, Peet, Caroline, Dranow, David M., Robinson, David A., Jansen, Chimed, Norcross, Neil R., Vinayak, Sumiti, Anderson, Mark, Brooks, Carrie F., Cooper, Caitlin A., Damerow, Sebastian, Delves, Michael, Dowers, Karen, Duffy, James, Edwards, Thomas E., Hallyburton, Irene, Horst, Benjamin G., Hulverson, Matthew A., Ferguson, Liam, Jiménez-Díaz, María Belén, Jumani, Rajiv S., Lorimer, Donald D., Love, Melissa S., Maher, Steven, Matthews, Holly, McNamara, Case W., Miller, Peter, O’Neill, Sandra, Ojo, Kayode K., Osuna-Cabello, Maria, Pinto, Erika, Post, John, Riley, Jennifer, Rottmann, Matthias, Sanz, Laura M., Scullion, Paul, Sharma, Arvind, Shepherd, Sharon M., Shishikura, Yoko, Simeons, Frederick R. C., Stebbins, Erin E., Stojanovski, Laste, Straschil, Ursula, Tamaki, Fabio K., Tamjar, Jevgenia, Torrie, Leah S., Vantaux, Amélie, Witkowski, Benoît, Wittlin, Sergio, Yogavel, Manickam, Zuccotto, Fabio, Angulo-Barturen, Iñigo, Sinden, Robert, Baum, Jake, Gamo, Francisco-Javier, Mäser, Pascal, Kyle, Dennis E., Winzeler, Elizabeth A., Myler, Peter J., Wyatt, Paul G., Floyd, David, Matthews, David, Sharma, Amit, Striepen, Boris, Huston, Christopher D., Gray, David W., Fairlamb, Alan H., Pisliakov, Andrei V., Walpole, Chris, Read, Kevin D., Van Voorhis, Wesley C., Gilbert, Ian H.

Volltext

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase von Milne, Rachel, Wiedemar, Natalie, Corpas-Lopez, Victoriano, Moynihan, Eoin, Wall, Richard J, Dawson, Alice, Robinson, David A, Shepherd, Sharon M, Smith, Robert J, Hallyburton, Irene, Post, John M, Dowers, Karen, Torrie, Leah S, Gilbert, Ian H, Baragaña, Beatriz, Patterson, Stephen, Wyllie, Susan

Volltext

Structure of Pseudomonas aeruginosa inosine 5-²-monophosphate dehydrogenase von Rao, Vincenzo A, Shepherd, Sharon M, Owen, Richard, Hunter, William N

Volltext

Structural and kinetic differences between human and Aspergillus fumigatus glucosamine N-acetyl transferase von Hurtado-Guerrero, Ramon, Raimi, Olawale G., Ming, Jinrong, Zeng, Hong, Vallius, Laura, Shepherd, Sharon M., Ibrahim, Adel F.M., Wu, Hong, Plotnikov, Alexander, van Aalten, Daan Mf

Volltext

Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia von Abman, Steven H., MD, Collaco, Joseph M., MD, PhD, Shepherd, Edward G., MD, Keszler, Martin, MD, Cuevas-Guaman, Milenka, MD, Welty, Stephen E., MD, Truog, William E., MD, McGrath-Morrow, Sharon A., MD, MBA, Moore, Paul E., MD, Rhein, Lawrence M., MD, Kirpalani, Haresh, BM, MSc, Zhang, Huayan, MD, Gratny, Linda L., MD, Lynch, Susan K., MD, Curtiss, Jennifer, RD, LD, Stonestreet, Barbara S., MD, McKinney, Robin L., MD, Dysart, Kevin C., MD, Gien, Jason, MD, Baker, Christopher D., MD, Donohue, Pamela K., MS, ScD, Austin, Eric, MD, MSCI, Fike, Candice, MD, Nelin, Leif D., MD

Volltext

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Isra... von Haas, Eric J, Angulo, Frederick J, McLaughlin, John M, Anis, Emilia, Singer, Shepherd R, Khan, Farid, Brooks, Nati, Smaja, Meir, Mircus, Gabriel, Pan, Kaijie, Southern, Jo, Swerdlow, David L, Jodar, Luis, Levy, Yeheskel, Alroy-Preis, Sharon

Volltext

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation von Lawlor, Kynan T., Vanslambrouck, Jessica M., Higgins, J. William, Chambon, Alison, Bishard, Kristina, Arndt, Derek, Er, Pei Xuan, Wilson, Sean B., Howden, Sara E., Tan, Ker Sin, Li, Fanyi, Hale, Lorna J., Shepherd, Benjamin, Pentoney, Stephen, Presnell, Sharon C., Chen, Alice E., Little, Melissa H.

Volltext