Overcoming Vemurafenib Resistance in Metastatic Melanoma: Targeting Integrins to Improve Treatment Efficacy von Boz Er, Asiye Busra, Sheldrake, Helen M, Sutherland, Mark

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Strategies to inhibit tumor associated integrin receptors: rationale for dual and multi-antagonists von Sheldrake, Helen M, Patterson, Laurence H

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Colon Cancer―Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins von TRAVICA, Sandra, PORS, Klaus, LOADMAN, Paul M, SHNYDER, Steven D, JOHANSSON, Inger, ALANDAS, Mohammed N, SHELDRAKE, Helen M, MKRTCHIAN, Souren, PATTERSON, Laurence H, INGELMAN-SUNDBERG, Magnus

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The Changing Faces of Halogenated Marine Natural Products: Total Synthesis of the Reported Structures of Elatenyne and an Enyne from Laurencia majuscula von Sheldrake, Helen M., Jamieson, Craig, Burton, Jonathan W.

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Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity von Sheldrake, Helen M, Travica, Sandra, Johansson, Inger, Loadman, Paul M, Sutherland, Mark, Elsalem, Lina, Illingworth, Nicola, Cresswell, Alexander J, Reuillon, Tristan, Shnyder, Steven D, Mkrtchian, Souren, Searcey, Mark, Ingelman-Sundberg, Magnus, Patterson, Laurence H, Pors, Klaus

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Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds von Ortuzar, Natalia, Karu, Kersti, Presa, Daniela, Morais, Goreti R., Sheldrake, Helen M., Shnyder, Steve D., Barnieh, Francis M., Loadman, Paul M., Patterson, Laurence H., Pors, Klaus, Searcey, Mark

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Intramolecular thermal stepwise [2 + 2] cycloadditions: investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones von Throup, Adam, Patterson, Laurence H, Sheldrake, Helen M

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Functionalized Cyclobutenes via Multicomponent Thermal [2 + 2] Cycloaddition Reactions von Sheldrake, Helen M, Wallace, Timothy W, Wilson, Craig P

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Sidechain structure-activity relationships of cyclobutane-based small molecule αvβ3 antagonists von Throup, Adam, Zraikat, Manar Saleh, Gordon, Andrew, Jafarinejad Soumehsaraei, Shohreh, Haase, Kathrin D, Patterson, Laurence H, Cooper, Patricia A, Hanlon, Katherine, Loadman, Paul M, Sutherland, Mark, Shnyder, Steven D, Sheldrake, Helen M

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RGD-Binding Integrins in Head and Neck Cancers von Ahmedah, Hanadi Talal, Patterson, Laurence H, Shnyder, Steven D, Sheldrake, Helen M

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RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis von Sutherland, Mark, Gordon, Andrew, Shnyder, Steven D, Patterson, Laurence H, Sheldrake, Helen M

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Synthesis and Biological Evaluation of Cyclobutane-Based β3 Integrin Antagonists: A Novel Approach to Targeting Integrins for Cancer Therapy von Sutherland, Mark, Gordon, Andrew, Al-Shammari, Fatemah O. F. O, Throup, Adam, Cilia La Corte, Amy, Philippou, Helen, Shnyder, Steven D, Patterson, Laurence H, Sheldrake, Helen M

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Strategies To Inhibit Tumor Associated Integrin Receptors: Rationale for Dual and Multi-Antagonists: Miniperspective von Sheldrake, Helen M, Patterson, Laurence H

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Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder von Sutherland, Mark, Gill, Jason H, Loadman, Paul M, Laye, Jonathan P, Sheldrake, Helen M, Illingworth, Nicola A, Alandas, Mohammed N, Cooper, Patricia A, Searcey, Mark, Pors, Klaus, Shnyder, Steve D, Patterson, Laurence H

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Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity von Pors, Klaus, Loadman, Paul M, Shnyder, Steven D, Sutherland, Mark, Sheldrake, Helen M, Guino, Meritxell, Kiakos, Konstantinos, Hartley, John A, Searcey, Mark, Patterson, Laurence H

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Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity von Santos, Ana R. N, Sheldrake, Helen M, Ibrahim, Ali I. M, Danta, Chhanda Charan, Bonanni, Davide, Daga, Martina, Oliaro-Bosso, Simonetta, Boschi, Donatella, Lolli, Marco L, Pors, Klaus

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Synthesis of the originally proposed structures of elatenyne and an enyne from Laurencia majuscula von Sheldrake, Helen M, Jamieson, Craig, Pascu, Sofia I, Burton, Jonathan W

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Synthesis of SB-214857 using Copper Catalysed Amination of Arylbromides with l-Aspartic Acid von Clement, Jean-Baptiste, Hayes, Jerome F., Sheldrake, Helen M., Sheldrake, Peter W., Wells, Andrew S.

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Manganese(III) acetate mediated synthesis of oxygen heterocycles. Influence of copper(II) salts on product distribution von Hulcoop, David G, Sheldrake, Helen M, Burton, Jonathan W

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Manganese(iii) acetate mediated synthesis of oxygen heterocycles. Influence of copper(ii) salts on product distributionElectronic supplementary information (ESI) available: spectro... von Hulcoop, David G., Sheldrake, Helen M., Burton, Jonathan W.

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