Circadian Rhythm Disruption Promotes Lung Tumorigenesis von Papagiannakopoulos, Thales, Bauer, Matthew R., Davidson, Shawn M., Heimann, Megan, Subbaraj, Lakshmipriya, Bhutkar, Arjun, Bartlebaugh, Jordan, Vander Heiden, Matthew G., Jacks, Tyler

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PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells von Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Jacks, Tyler, Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Vander Heiden, Matthew G.

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Critical Functions of the Lysosome in Cancer Biology von Davidson, Shawn M, Vander Heiden, Matthew G

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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer von Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.

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Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin von Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.

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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells von Commisso, Cosimo, Davidson, Shawn M., Soydaner-Azeloglu, Rengin G., Parker, Seth J., Kamphorst, Jurre J., Hackett, Sean, Grabocka, Elda, Nofal, Michel, Drebin, Jeffrey A., Thompson, Craig B., Rabinowitz, Joshua D., Metallo, Christian M., Vander Heiden, Matthew G., Bar-Sagi, Dafna

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Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids von LeBoeuf, Sarah E., Wu, Warren L., Karakousi, Triantafyllia R., Karadal, Burcu, Jackson, S. RaElle, Davidson, Shawn M., Wong, Kwok-Kin, Koralov, Sergei B., Sayin, Volkan I., Papagiannakopoulos, Thales

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Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors von Davidson, Shawn M, Jonas, Oliver, Keibler, Mark A, Hou, Han Wei, Luengo, Alba, Mayers, Jared R, Wyckoff, Jeffrey, Del Rosario, Amanda M, Whitman, Matthew, Chin, Christopher R, Condon, Kendall J, Lammers, Alex, Kellersberger, Katherine A, Stall, Brian K, Stephanopoulos, Gregory, Bar-Sagi, Dafna, Han, Jongyoon, Rabinowitz, Joshua D, Cima, Michael J, Langer, Robert, Vander Heiden, Matthew G

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate von Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M

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Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development von Mayers, Jared R, Wu, Chen, Clish, Clary B, Kraft, Peter, Torrence, Margaret E, Fiske, Brian P, Yuan, Chen, Bao, Ying, Townsend, Mary K, Tworoger, Shelley S, Davidson, Shawn M, Papagiannakopoulos, Thales, Yang, Annan, Dayton, Talya L, Ogino, Shuji, Stampfer, Meir J, Giovannucci, Edward L, Qian, Zhi Rong, Rubinson, Douglas A, Ma, Jing, Sesso, Howard D, Gaziano, John M, Cochrane, Barbara B, Liu, Simin, Wactawski-Wende, Jean, Manson, JoAnn E, Pollak, Michael N, Kimmelman, Alec C, Souza, Amanda, Pierce, Kerry, Wang, Thomas J, Gerszten, Robert E, Fuchs, Charles S, Vander Heiden, Matthew G, Wolpin, Brian M

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Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma von Dayton, Talya L, Gocheva, Vasilena, Miller, Kathryn M, Israelsen, William J, Bhutkar, Arjun, Clish, Clary B, Davidson, Shawn M, Luengo, Alba, Bronson, Roderick T, Jacks, Tyler, Vander Heiden, Matthew G

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IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism von GRASSIAN, Alexandra R, PARKER, Seth J, JOUD-CALDWELL, Carol, CHUNG, Franklin, HONG YIN, HANDLY, Erika D, STRAUB, Christopher, GROWNEY, Joseph D, HEIDEN, Matthew G. Vander, MURPHY, Anne N, PAGLIARINI, Raymond, METALLO, Christian M, DAVIDSON, Shawn M, DIVAKARUNI, Ajit S, GREEN, Courtney R, XIAMEI ZHANG, SLOCUM, Kelly L, MINYING PU, LIN, Fallon, VICKERS, Chad

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Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer von Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Faubert, Brandon, Chan, Sze Ham, Freinkman, Elizaveta, Zacharias, Lauren G., Mathews, Thomas P., Clish, Clary B., DeBerardinis, Ralph J., Lewis, Caroline A., Vander Heiden, Matthew G.

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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer von Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Davidson, Shawn M, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Muir, Alexander, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Vander Heiden, Matthew G, Papagiannakopoulos, Thales

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EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection von Olenchock, Benjamin A., Moslehi, Javid, Baik, Alan H., Davidson, Shawn M., Williams, Jeremy, Gibson, William J., Chakraborty, Abhishek A., Pierce, Kerry A., Miller, Christine M., Hanse, Eric A., Kelekar, Ameeta, Sullivan, Lucas B., Wagers, Amy J., Clish, Clary B., Vander Heiden, Matthew G., Kaelin, William G.

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Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism von FENDT, Sarah-Maria, BELL, Eric L, PATNAIK, Akash, BLOUIN, Marie Jose, CANTLEY, Lewis C, GUARENTE, Leonard, BLENIS, John, POLLAK, Michael N, OLUMI, Aria F, VANDER HEIDEN, Matthew G, STEPHANOPOULOS, Gregory, KEIBLER, Mark A, DAVIDSON, Shawn M, WIRTH, Gregory J, FISKE, Brian, MAYERS, Jared R, SCHWAB, Matthias, BELLINGER, Gary, CSIBI, Alfredo

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Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma von Lau, Allison N, Li, Zhaoqi, Danai, Laura V, Westermark, Anna M, Darnell, Alicia M, Ferreira, Raphael, Gocheva, Vasilena, Sivanand, Sharanya, Lien, Evan C, Sapp, Kiera M, Mayers, Jared R, Biffi, Giulia, Chin, Christopher R, Davidson, Shawn M, Tuveson, David A, Jacks, Tyler, Matheson, Nicholas J, Yilmaz, Omer, Vander Heiden, Matthew G

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Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers von Price, Colles, Gill, Stanley, Ho, Zandra V, Davidson, Shawn M, Merkel, Erin, McFarland, James M, Leung, Lisa, Tang, Andrew, Kost-Alimova, Maria, Tsherniak, Aviad, Jonas, Oliver, Vazquez, Francisca, Hahn, William C

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Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism von Baytas, Ozan, Davidson, Shawn M, Kauer, Julie A, Morrow, Eric M

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Multi-omic analysis of Huntington’s disease reveals a compensatory astrocyte state von Paryani, Fahad, Kwon, Ji-Sun, Ng, Christopher W., Jakubiak, Kelly, Madden, Nacoya, Ofori, Kenneth, Tang, Alice, Lu, Hong, Xia, Shengnan, Li, Juncheng, Mahajan, Aayushi, Davidson, Shawn M., Basile, Anna O., McHugh, Caitlin, Vonsattel, Jean Paul, Hickman, Richard, Zody, Michael C., Housman, David E., Goldman, James E., Yoo, Andrew S., Menon, Vilas, Al-Dalahmah, Osama

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