Phase 1 study of M2698, a p70S6K/AKT dual inhibitor, in patients with advanced cancer von Tsimberidou, Apostolia-Maria, Shaw, Jamie V, Juric, Dejan, Verschraegen, Claire, Weise, Amy M, Sarantopoulos, John, Lopes, Gilberto, Nemunaitis, John, Mita, Monica, Park, Haeseong, Ellers-Lenz, Barbara, Tian, Hui, Xiong, Wenyuan, Kaleta, Remigiusz, Kurzrock, Razelle

Volltext

Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8 von Port, Andreas, Shaw, Jamie V., Klopp‐Schulze, Lena, Bytyqi, Afrim, Vetter, Claudia, Hussey, Elizabeth, Mammasse, Nadra, Ona, Victor, Bachmann, Angelika, Strugala, Denis, Reh, Christian, Goteti, Kosalaram

Volltext

Applying Modeling and Simulations for Rational Dose Selection of Novel Toll‐Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need von Klopp‐Schulze, Lena, Shaw, Jamie V., Dong, Jennifer Q., Khandelwal, Akash, Vazquez‐Mateo, Cristina, Goteti, Kosalaram

Volltext

Abstract LB-456: Evaluation of brain pharmacokinetics as a potential differentiation factor for the MEK inhibitors, MSC2015103 and pimasertib von Shaw, Jamie V., Zhang, Hong, Carden, Riham, Qiu, Daniel, Tian, Hui, Ma, Jianguo, Clark, Anderson, Ogden, Janet, Goodstal, Samantha

Volltext

Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations von Zhang, Zhijun, Almeida, Sandra, Lu, Yubing, Nishimura, Agnes L, Peng, Lingtao, Sun, Danqiong, Wu, Bei, Karydas, Anna M, Tartaglia, Maria C, Fong, Jamie C, Miller, Bruce L, Farese, Jr, Robert V, Moore, Melissa J, Shaw, Christopher E, Gao, Fen-Biao

Volltext

Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth von Wagh, Kshitij, Kreider, Edward F., Li, Yingying, Barbian, Hannah J., Learn, Gerald H., Giorgi, Elena, Hraber, Peter T., Decker, Timothy G., Smith, Andrew G., Gondim, Marcos V., Gillis, Lindsey, Wandzilak, Jamie, Chuang, Gwo-Yu, Rawi, Reda, Cai, Fangping, Pellegrino, Pierre, Williams, Ian, Overbaugh, Julie, Gao, Feng, Kwong, Peter D., Haynes, Barton F., Shaw, George M., Borrow, Persephone, Seaman, Michael S., Hahn, Beatrice H., Korber, Bette

Volltext

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets von Alexander, Stephen PH, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Buneman, O Peter, Cidlowski, John A, Christopoulos, Arthur, Davenport, Anthony P, Fabbro, Doriano, Spedding, Michael, Striessnig, Jörg, Davies, Jamie A, Ahlers‐Dannen, Katelin E., Alqinyah, Mohammed, Arumugam, Thiruma V., Bodle, Christopher, Dagner, Josephine Buo, Chakravarti, Bandana, Choudhuri, Shreoshi P., Druey, Kirk M., Fisher, Rory A., Gerber, Kyle J., Hepler, John R., Hooks, Shelley B., Kantheti, Havish S., Karaj, Behirda, Layeghi‐Ghalehsoukhteh, Somayeh, Lee, Jae‐Kyung, Luo, Zili, Martemyanov, Kirill, Mascarenhas, Luke D., McNabb, Harrison, Montañez‐Miranda, Carolina, Ogujiofor, Osita, Phan, Hoa, Roman, David L., Shaw, Vincent, Sjogren, Benita, Sobey, Christopher, Spicer, Mackenzie M., Squires, Katherine E., Sutton, Laurie, Wendimu, Menbere, Wilkie, Thomas, Xie, Keqiang, Zhang, Qian, Zolghadri, Yalda

Volltext

The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets von Alexander, Stephen P. H., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Buneman, O. Peter, Faccenda, Elena, Harding, Simon D., Spedding, Michael, Cidlowski, John A., Fabbro, Doriano, Davenport, Anthony P., Striessnig, Jörg, Davies, Jamie A., Ahlers‐Dannen, Katelin E., Alqinyah, Mohammed, Arumugam, Thiruma V., Bodle, Christopher, Dagner, Josephine Buo, Chakravarti, Bandana, Choudhuri, Shreoshi P., Druey, Kirk M., Fisher, Rory A., Gerber, Kyle J., Hepler, John R., Hooks, Shelley B., Kantheti, Havish S., Karaj, Behirda, Layeghi‐Ghalehsoukhteh, Somayeh, Lee, Jae‐Kyung, Luo, Zili, Martemyanov, Kirill, Mascarenhas, Luke D., McNabb, Harrison, Montañez‐Miranda, Carolina, Ogujiofor, Osita, Phan, Hoa, Roman, David L., Shaw, Vincent, Sjogren, Benita, Sobey, Christopher, Spicer, Mackenzie M., Squires, Katherine E., Sutton, Laurie, Wendimu, Menbere, Wilkie, Thomas, Xie, Keqiang, Zhang, Qian, Zolghadri, Yalda

Volltext

Clinical and pathologic evaluation of chorioretinal lesions in wild owl species von Keenan, Alessandra V., Oster, Seth, McMullen, Richard J., Shaw, Gillian C., Dubielzig, Richard R., Teixeira, Leandro B. C., Bellah, Jamie R., Moore, Phillip A., Boveland, Shannon D.

Volltext

The Genomic Signature and Transcriptional Response of Metal Tolerance in Brown Trout Inhabiting Metal-Polluted Rivers von Paris, Josephine R, King, R Andrew, Ferrer Obiol, Joan, Shaw, Sophie, Lange, Anke, Bourret, Vincent, Hamilton, Patrick B, Rowe, Darren, Laing, Lauren V, Farbos, Audrey, Moore, Karen, Urbina, Mauricio A, van Aerle, Ronny, Catchen, Julian M, Wilson, Rod W, Bury, Nicolas R, Santos, Eduarda M, Stevens, Jamie R

Volltext

A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications von Abbott, T.E.F., Fowler, A.J., Pelosi, P., Gama de Abreu, M., Møller, A.M., Canet, J., Creagh-Brown, B., Mythen, M., Gin, T., Lalu, M.M., Futier, E., Grocott, M.P., Schultz, M.J., Pearse, R.M., Myles, P., Gan, T.J., Kurz, A., Peyton, P., Sessler, D., Tramèr, M., Cyna, A., De Oliveira, G.S., Wu, C., Jensen, M., Kehlet, H., Botti, M., Boney, O., Haller, G., Grocott, M., Cook, T., Fleisher, L., Neuman, M., Story, D., Gruen, R., Bampoe, S., Evered, Lis, Scott, D., Silbert, B., van Dijk, D., Kalkman, C., Chan, M., Grocott, H., Eckenhoff, R., Rasmussen, L., Eriksson, L., Beattie, S., Wijeysundera, D., Landoni, G., Leslie, K., Biccard, B., Howell, S., Nagele, P., Richards, T., Lamy, A., Gabreu, M., Klein, A., Corcoran, T., Jamie Cooper, D., Dieleman, S., Diouf, E., McIlroy, D., Bellomo, R., Shaw, A., Prowle, J., Karkouti, K., Billings, J., Mazer, D., Jayarajah, M., Murphy, M., Bartoszko, J., Sneyd, R., Morris, S., George, R., Moonesinghe, R., Shulman, M., Lane-Fall, M., Nilsson, U., Stevenson, N., van Klei, W., Cabrini, L., Miller, T., Pace, N., Jackson, S., Buggy, D., Short, T., Riedel, B., Gottumukkala, V., Alkhaffaf, B., Johnson, M.

Volltext

Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas von Anglesio, Michael S, Kommoss, Stefan, Tolcher, Mary C, Clarke, Blaise, Galletta, Laura, Porter, Henry, Damaraju, Sambasivarao, Fereday, Sian, Winterhoff, Boris J, Kalloger, Steve E, Senz, Janine, Yang, Winnie, Steed, Helen, Allo, Ghassan, Ferguson, Sarah, Shaw, Patricia, Teoman, Attila, Garcia, Joaquin J, Schoolmeester, John K, Bakkum-Gamez, Jamie, Tinker, Anna V, Bowtell, David D, Huntsman, David G, Gilks, C Blake, McAlpine, Jessica N

Volltext

Standardized Data Elements for Patients With Acute Pulmonary Embolism: A Consensus Report From the Pulmonary Embolism Research Collaborative von Rosenfield, Kenneth, Bowers, Terry R, Barnett, Christopher F, Davis, George A, Giri, Jay, Horowitz, James M, Huisman, Menno V, Hunt, Beverley J, Keeling, Brent, Kline, Jeffrey A, Klok, Frederikus A, Konstantinides, Stavros V, Lanno, Michelle T, Lookstein, Robert, Moriarty, John M, Ní Áinle, Fionnuala, Reed, Jamie L, Rosovsky, Rachel P, Royce, Sara M, Secemsky, Eric A, Sharp, Andrew S P, Sista, Akhilesh K, Smith, Roy E, Wells, Phil, Yang, Joanna, Whatley, Eleni M

Volltext

Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability von Grozeva, Detelina, Carss, Keren, Spasic-Boskovic, Olivera, Tejada, Maria-Isabel, Gecz, Jozef, Shaw, Marie, Corbett, Mark, Haan, Eric, Thompson, Elizabeth, Friend, Kathryn, Hussain, Zaamin, Hackett, Anna, Field, Michael, Renieri, Alessandra, Stevenson, Roger, Schwartz, Charles, Floyd, James A.B., Bentham, Jamie, Cosgrove, Catherine, Keavney, Bernard, Bhattacharya, Shoumo, Hurles, Matthew, Raymond, F. Lucy

Volltext

Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q von Murphy, Andrew J., Cheng, Changde, Williams, Justin, Shaw, Timothy I., Pinto, Emilia M., Dieseldorff-Jones, Karissa, Brzezinski, Jack, Renfro, Lindsay A., Tornwall, Brett, Huff, Vicki, Hong, Andrew L., Mullen, Elizabeth A., Crompton, Brian, Dome, Jeffrey S., Fernandez, Conrad V., Geller, James I., Ehrlich, Peter F., Mulder, Heather, Oak, Ninad, Maciezsek, Jamie, Jablonowski, Carolyn M., Fleming, Andrew M., Pichavaram, Prahalathan, Morton, Christopher L., Easton, John, Nichols, Kim E., Clay, Michael R., Santiago, Teresa, Zhang, Jinghui, Yang, Jun, Zambetti, Gerard P., Wang, Zhaoming, Davidoff, Andrew M., Chen, Xiang

Volltext

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma von Panditharatna, Eshini, Marques, Joana G, Wang, Tingjian, Trissal, Maria C, Liu, Ilon, Jiang, Li, Beck, Alexander, Groves, Andrew, Dharia, Neekesh V, Li, Deyao, Hoffman, Samantha E, Kugener, Guillaume, Shaw, McKenzie L, Mire, Hafsa M, Hack, Olivia A, Dempster, Joshua M, Lareau, Caleb, Dai, Lingling, Sigua, Logan H, Quezada, Michael A, Stanton, Ann-Catherine J, Wyatt, Meghan, Kalani, Zohra, Goodale, Amy, Vazquez, Francisca, Piccioni, Federica, Doench, John G, Root, David E, Anastas, Jamie N, Jones, Kristen L, Conway, Amy Saur, Stopka, Sylwia, Regan, Michael S, Liang, Yu, Seo, Hyuk-Soo, Song, Kijun, Bashyal, Puspalata, Jerome, William P, Mathewson, Nathan D, Dhe-Paganon, Sirano, Suvà, Mario L, Carcaboso, Angel M, Lavarino, Cinzia, Mora, Jaume, Nguyen, Quang-De, Ligon, Keith L, Shi, Yang, Agnihotri, Sameer, Agar, Nathalie Y R, Stegmaier, Kimberly, Stiles, Charles D, Monje, Michelle, Golub, Todd R, Qi, Jun, Filbin, Mariella G

Volltext

Centers for Mendelian Genomics: A decade of facilitating gene discovery von Lake, Nicole J., Sobreira, Nara, Chong, Jessica X., Chadwick, Lisa H., Coban-Akdemir, Zeynep H., Doheny, Kimberly F., Lek, Monkol, Jhangiani, Shalini N., Lifton, Richard P., Matise, Tara C., Lupski, James R., Valle, David, Nickerson, Deborah A., Akay, Gulsen, Antonescu, Corina, Austin-Tse, Christina A., Bacus, Tamara J., Bahrambeigi, Vahid, Belmont, John W., Below, Jennifer E., Bilguvar, Kaya, Boehm, Corinne D., Boone, Philip M., Calame, Daniel, Cao, Xiaolong, Carvalho, Claudia, Chander, Varuna, Clarke, Declan, Delano, Kayla, Doddapaneni, Harshavardhan, Du, Renqian, Fatih, Jawid, Francioli, Laurent C., Fu, Jack, Gambin, Tomasz, Gandhi, Mira, Ganesh, Vijay S., Garimella, Kiran V., Gauthier, Laura D., Gonzaga-Jauregui, Claudia, Grochowski, Christopher M., Gu, Shen, Hansen, Adam, Harmanci, Arif O., Huang, Yongqing, Johanson, Eric, Karaca, Ender, Kumar, Sushant, Laricchia, Kristen M., Ling, Hua, Lipson, Rachel B., MacMillan, Melissa P., Marshall, Jamie L., Martin, Renan, McGee, Sean, Mekonnen, Betselote, Mullen, Thomas E., Murugan, Mullai, Muzny, Donna M., Myers, Ben, Neira, Juanita, Nielsen, Patrick M., Nudelman, Natalie, O’Leary, Melanie C., Pais, Lynn S., Patterson, Karynne, Pehlivan, Davut, Penney, Samantha, Pierce-Hoffman, Emma, Radhakrishnan, Aparna, Richardson, Matthew A., Roote, Gwendolin T., Sabo, Aniko, Scott, Daryl A., Shaw, Chad A., Shelford, Tameka, Shively, Kathryn M., Snow, Hana, Solomonson, Matthew, Song, Xiaofei, Stephan, Taylorlyn, Sutton, V. Reid, Sveden, Abigail, Valivullah, Zaheer, Wang, Lu, Wangler, Michael F., Watts, Nicholas A., Wilson, Michael W., Wiszniewski, Wojciech, Witmer, Dane, Witzgall, Lauren, Wohler, Elizabeth, Wu, Nan, Yi, Qian, Zeiger, Jordan E., Zhang, Chaofan, Zhang, Yeting, Zoghbi, Huda, van den Veyver, Igna, O’Donnell-Luria, Anne

Volltext

Systematic review and consensus definitions for standardised endpoints in perioperative medicine: postoperative cancer outcomes von Buggy, D.J., Freeman, J., Johnson, M.Z., Leslie, K., Riedel, B., Sessler, D.I., Kurz, A., Gottumukkala, V., Short, T., Pace, N., Myles, P.S., Gan, T.J., Peyton, P., Tramèr, M., Cyna, A., De Oliveira, G.S., Wu, C., Jensen, M., Kehlet, H., Botti, M., Boney, O., Haller, G., Grocott, M., Cook, T., Fleisher, L., Neuman, M., Story, D., Gruen, R., Bampoe, S., Evered, Lis, Scott, D., Silbert, B., van Dijk, D., Kalkman, C., Chan, M., Grocott, H., Eckenhoff, R., Rasmussen, L., Eriksson, L., Beattie, S., Wijeysundera, D., Landoni, G., Biccard, B., Howell, S., Nagele, P., Richards, T., Lamy, A., Lalu, M., Pearse, R., Mythen, M., Canet, J., Moller, A., Gin, T., Schultz, M., Pelosi, P., Gabreu, M., Futier, E., Creagh-Brown, B., Abbott, T., Klein, A., Corcoran, T., Jamie Cooper, D., Dieleman, S., Diouf, E., McIlroy, D., Bellomo, R., Shaw, A., Prowle, J., Karkouti, K., Billings, J., Mazer, D., Jayarajah, M., Murphy, M., Bartoszko, J., Sneyd, R., Morris, S., George, R., Moonesinghe, R., Shulman, M., Lane-Fall, M., Nilsson, U., Stevenson, N., van Klei, W., Cabrini, L., Miller, T., Jackson, S., Alkhaffaf, B.

Volltext

Physiological Demands of Off-Road Vehicle Riding von BURR, Jamie F, JAMNIK, Veronica K, SHAW, Jim A, GLEDHILL, Norman

Volltext

The Concise Guide to PHARMACOLOGY 2021/22 von Alexander, Stephen P H, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Buneman, O Peter, Cidlowski, John A, Christopoulos, Arthur, Davenport, Anthony P, Fabbro, Doriano, Spedding, Michael, Striessnig, Jörg, Davies, Jamie A, Katelin E Ahlers‐Dannen, Alqinyah, Mohammed, Arumugam, Thiruma V, Bodle, Christopher, Dagner, Josephine Buo, Chakravarti, Bandana, Choudhuri, Shreoshi P, Druey, Kirk M, Fisher, Rory A, Gerber, Kyle J, Hepler, John R, Hooks, Shelley B, Kantheti, Havish S, Karaj, Behirda, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Luo, Zili, Martemyanov, Kirill, Mascarenhas, Luke D, McNabb, Harrison, Carolina Montañez‐Miranda, Ogujio, Osita, Phan, Hoa, Roman, David L, Shaw, Vincent, Sjogren, Benita, Sobey, Christopher, Spicer, Mackenzie M, Squires, Katherine E, Sutton, Laurie, Menbere Wendimu, Wilkie, Thomas, Xie, Keqiang, Zhang, Qian, Zolghadri, Yalda

Volltext