Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks von Orr, Suvi T. M, Ripp, Sharon L, Ballard, T. Eric, Henderson, Jaclyn L, Scott, Dennis O, Obach, R. Scott, Sun, Hao, Kalgutkar, Amit S

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A Case to Support the Continued Use of Rifampin in Clinical Drug–Drug Interaction Studies von Bercu, Joel P., Ponting, David J., Ripp, Sharon L., Dobo, Krista L., Totah, Rheem A., Bolleddula, Jayaprakasam

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Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs von Sharma, Raman, Strelevitz, Timothy J, Gao, Hongying, Clark, Alan J, Schildknegt, Klaas, Obach, R Scott, Ripp, Sharon L, Spracklin, Douglas K, Tremaine, Larry M, Vaz, Alfin D N

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Comparative nonclinical assessments of the biosimilar PF-06410293 and originator adalimumab von Derzi, Mazin, Shoieb, Ahmed M., Ripp, Sharon L., Finch, Gregory L., Lorello, Leslie G., O'Neil, Shawn P., Radi, Zaher, Syed, Jameel, Thompson, Matthew S., Leach, Michael W.

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DHEA metabolites activate estrogen receptors alpha and beta von Michael Miller, Kristy K., Al-Rayyan, Numan, Ivanova, Margarita M., Mattingly, Kathleen A., Ripp, Sharon L., Klinge, Carolyn M., Prough, Russell A.

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Regulation of CYP2C11 by Dehydroepiandrosterone and Peroxisome Proliferators: Identification of the Negative Regulatory Region of the Gene von Ripp, Sharon L, Falkner, K Cameron, Pendleton, Mary L, Tamasi, Viola, Prough, Russell A

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In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF‐00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor von Ripp, Sharon L., Mukherjee, Arnab, Eng, Heather, Stock, Thomas, Fleishaker, Dona, Checchio, Tina, Tammara, Brinda

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Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections von Magee, Thomas V, Ripp, Sharon L, Li, Bryan, Buzon, Richard A, Chupak, Lou, Dougherty, Thomas J, Finegan, Steven M, Girard, Dennis, Hagen, Anne E, Falcone, Michael J, Farley, Kathleen A, Granskog, Karl, Hardink, Joel R, Huband, Michael D, Kamicker, Barbara J, Kaneko, Takushi, Knickerbocker, Michael J, Liras, Jennifer L, Marra, Andrea, Medina, Ivy, Nguyen, Thuy-Trinh, Noe, Mark C, Obach, R. Scott, O’Donnell, John P, Penzien, Joseph B, Reilly, Usa Datta, Schafer, John R, Shen, Yue, Stone, Gregory G, Strelevitz, Timothy J, Sun, Jianmin, Tait-Kamradt, Amelia, Vaz, Alfin D. N, Whipple, David A, Widlicka, Daniel W, Wishka, Donn G, Wolkowski, Joanna P, Flanagan, Mark E

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Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators von Tamasi, Viola, Miller, Kristy K Michael, Ripp, Sharon L, Vila, Ermin, Geoghagen, Thomas E, Prough, Russell A

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Oxidative Metabolism of Seleno-l-methionine to l-Methionine Selenoxide by Flavin-Containing Monooxygenases von Krause, Renee J., Glocke, Steven C., Sicuri, Anna Rita, Ripp, Sharon L., Elfarra, Adnan A.

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Effect of moxidectin on CYP3A4 activity as evaluated by oral midazolam pharmacokinetics in healthy subjects von Korth-Bradley, Joan M., Parks, Virginia, Wagner, Frank, Chalon, Stephan, Gourley, Ian, Matschke, Kyle, Gossart, Sophie, Ripp, Sharon L., Fleckenstein, Lawrence

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A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole... von Kalgutkar, Amit S, Driscoll, James, Zhao, Sabrina X, Walker, Gregory S, Shepard, Richard M, Soglia, John R, Atherton, James, Yu, Linning, Mutlib, Abdul E, Munchhof, Michael J, Reiter, Lawrence A, Jones, Christopher S, Doty, Johnathan L, Trevena, Kristen A, Shaffer, Christopher L, Ripp, Sharon L

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Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: A combination study design in support of a Paediatric Investigation Plan von Cross, David M., Chmielewski, Gary, Lewis, Elise M., Liu, Lei, Modesitt, Michael S., Ripp, Sharon L., Sawaryn, Christopher M., Bowman, Christopher J.

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Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11β-hydroxysteroid dehydrogenases? von Robinzon, Boaz, Michael, Kristy K, Ripp, Sharon L, Winters, Stephen J, Prough, Russell A

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Structure–activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor von Antipas, Amy S., Blumberg, Laura C., Brissette, William H., Brown, Matthew F., Casavant, Jeffrey M., Doty, Jonathan L., Driscoll, James, Harris, Thomas M., Jones, Christopher S., McCurdy, Sandra P., McElroy, Eric, Mitton-Fry, Mark, Munchhof, Michael J., Reim, David A., Reiter, Lawrence A., Ripp, Sharon L., Shavnya, Andrei, Smeets, Marc I., Trevena, Kristen A.

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Tissue Distribution of Anidulafungin in Neonatal Rats von Ripp, Sharon L., Aram, Jalal A., Bowman, Christopher J., Chmielewski, Gary, Conte, Umberto, Cross, David M., Gao, Hongying, Lewis, Elise M., Lin, Jian, Liu, Ping, Schlamm, Haran T.

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Dehydroepiandrosterone affects the expression of multiple genes in rat liver including 11 beta-hydroxysteroid dehydrogenase type 1: a cDNA array analysis von Gu, Shi, Ripp, Sharon L, Prough, Russell A, Geoghegan, Thomas E

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The identification of orally bioavailable thrombopoietin agonists von Munchhof, Michael J., Antipas, Amy S., Blumberg, Laura C., Brissette, William H., Brown, Matthew F., Casavant, Jeffrey M., Doty, Jonathan L., Driscoll, James, Harris, Thomas M., Wolf-Gouveia, Lilli A., Jones, Christopher S., Li, Qifang, Linde, Robert G., Lira, Paul D., Marfat, Anthony, McElroy, Eric, Mitton-Fry, Mark, McCurdy, Sandra P., Reiter, Lawrence A., Ripp, Sharon L., Shavnya, Andrei, Thomasco, Lisa M., Trevena, Kristen A.

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Pyrimidine benzamide-based thrombopoietin receptor agonists von Reiter, Lawrence A., Subramanyam, Chakrapani, Mangual, Emilio J., Jones, Christopher S., Smeets, Marc I., Brissette, William H., McCurdy, Sandra P., Lira, Paul D., Linde, Robert G., Li, Qifang, Zhang, Fangning, Antipas, Amy S., Blumberg, Laura C., Doty, Jonathan L., Driscoll, James P., Munchhof, Michael J., Ripp, Sharon L., Shavnya, Andrei, Shepard, Richard M., Sperger, Diana, Thomasco, Lisa M., Trevena, Kristen A., Wolf-Gouveia, Lilli A., Zhang, Liling

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Modulation of Receptor Phosphorylation Contributes to Activation of Peroxisome Proliferator Activated Receptor α by Dehydroepiandrosterone and Other Peroxisome Proliferators von Viola Tamasi, Kristy K. Michael Miller, Sharon L. Ripp, Ermin Vila, Thomas E. Geoghagen, Russell A. Prough

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