Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene von Lomovskaya, N, Otten, S L, Doi-Katayama, Y, Fonstein, L, Liu, X C, Takatsu, T, Inventi-Solari, A, Filippini, S, Torti, F, Colombo, A L, Hutchinson, C R

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The dnrO gene encodes a DNA-binding protein that regulates daunorubicin production in Streptomyces peucetius by controlling expression of the dnrN pseudo response regulator gene von Otten, Sharee L, Olano, Carlos, Hutchinson, C. Richard

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Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius von STUTZMAN-ENGWALL, K. J, OTTEN, S. L, RICHARD HUTCHINSON, C

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Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosa... von Otten, S L, Gallo, M A, Madduri, K, Liu, X, Hutchinson, C R

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A perspective on drug discovery and development through the genetic engineering of antibiotic-producing microorganisms von Hutchinson, C. Richard, Borell, Christopher W, Otten, Sharee L, Stutzman-Engwall, Kim J, Wang, Yi Guang

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Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus von Otten, S L, Ferguson, J, Hutchinson, C R

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FREQUENT LOSS AND RESTORATION OF ANTIBIOTIC PRODUCTION BY STREPTOMYCES LASALIENSIS von KINASHI, HARUYASU, OTTEN, SHAREE L., DUNCANN, JANICE S., HUTCHINSON, C. RICHARD

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Microbial Transformations of Natural Antitumor Agents. 17. Conversions of Lapachol by Cunninghamella echinulata von Otten, Sharee L, Rosazza, John P

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Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosythesis enzyme and a glycosyl transferase involved in daunorubicin biosythesis von Otten, Sharee L, Liu, Xiaochun, Ferguson, Jane, Hutchinson, C Richard

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Doxorubicin Overproduction in Streptomyces peucetius: Cloning and Characterization of the dnrU Ketoreductase anddnrV Genes and the doxA Cytochrome P-450 Hydroxylase Gene von Natalie Lomovskaya, Sharee L. Otten, Yukiko Doi-Katayama, Leonid Fonstein, Xiao-Chun Liu, Toshio Takatsu, Augusto Inventi-Solari, Silvia Filippini, Francesca Torti, Anna Luisa Colombo, C. Richard Hutchinson

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Genetic control of polyketide biosynthesis in the genus Streptomyces von Hutchinson, C R, Decker, H, Madduri, K, Otten, S L, Tang, L

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Genetic control of polyketide biosynthesis in the genusStreptomyces von Hutchinson, C. Richard, Decker, Heinrich, Madduri, Krishnamurthy, Otten, Sharee L., Tang, Li

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Drug discovery and development through the genetic engineering of antibiotic-producing microorganisms von Hutchinson, C R, Borell, C W, Otten, S L, Stutzman-Engwall, K J, Wang, Y G

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PROCESS FOR PREPARING DOXORUBICIN von UMBERTO BREME, RICHARD C HUTCHINSON, SHAREE L OTTEN

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PROCESS FOR PREPARING DOXORUBICIN von COLOMBO, ANNA, LUISA, OTTEN, SHAREE L, FONSTEIN, LEONID, HUTCHINSON, RICHARD, C, FILIPPINI, SILVIA, LOMOVSKAYA, NATALIA, BREME, UMBERTO

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PROCESS FOR PREPARING DOXORUBICIN von OTTEN, SHAREE L, COLOMBO, ANNALUISA, FONSTEIN, LEONID, FILIPPINI, SILVIA, LOMOVSKAYA, NATALIA, HUTCHINSON, CHARLES RICHARD, BREME, UMBERTO

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Process for preparing doxorubicin von UMBERTO BREME, RICHARD C HUTCHINSON, SILVIA FILIPPINI, SHAREE L OTTEN, ANNA LUISA COLOMBO, NATALIA LOMOVSKAYA, LEONID FONSTEIN

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Process for preparing doxorubicin von UMBERTO BREME, RICHARD C HUTCHINSON, SILVIA FILIPPINI, SHAREE L OTTEN, ANNA LUISA COLOMBO, NATALIA LOMOVSKAYA, LEONID FONSTEIN

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Process for preparing doxorubicin von FONSTEIN LEONID, COLOMBO ANNA LUISA, BREME UMBERTO, FILIPPINI SILVIA, OTTEN SHAREE L, LOMOVSKAYA NATALIA, HUTCHINSON C. RICHARD

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PROCESS FOR PREPARING DOXORUBICIN von COLOMBO, ANNA, LUISA, OTTEN, SHAREE L, FONSTEIN, LEONID, HUTCHINSON, RICHARD, C, FILIPPINI, SILVIA, LOMOVSKAYA, NATALIA, BREME, UMBERTO

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