Theoretical Studies of Chemical Reactivity of Metabolically Activated Forms of Aromatic Amines toward DNA von Shamovsky, Igor, Ripa, Lena, Blomberg, Niklas, Eriksson, Leif A, Hansen, Peter, Mee, Christine, Tyrchan, Christian, O'Donovan, Mike, Sjö, Peter

Volltext

Theoretical Studies of the Mechanism of Carbamoylation of Nucleobases by Isocyanates von Liljenberg, Magnus, Ripa, Lena, Shamovsky, Igor

Volltext

Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations von Shamovsky, Igor, Ripa, Lena, Narjes, Frank, Bonn, Britta, Schiesser, Stefan, Terstiege, Ina, Tyrchan, Christian

Volltext

Theoretical Studies on the Origin of β-sheet Twisting von Shamovsky, Igor L, Ross, Gregory M, Riopelle, Richard J

Volltext

Selective and Bioavailable HDAC6 2‑(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism von Ripa, Lena, Sandmark, Jenny, Hughes, Glyn, Shamovsky, Igor, Gunnarsson, Anders, Johansson, Julia, Llinas, Antonio, Collins, Mia, Jung, Bomi, Novén, Anna, Pemberton, Nils, Mogemark, Mickael, Xiong, Yao, Li, Qing, Tångefjord, Stefan, Ek, Margareta, Åstrand, Annika

Volltext

Ab Initio Studies on the Mechanism of Tyrosine Coupling von Shamovsky, Igor L, Riopelle, Richard J, Ross, Gregory M

Volltext

Discovery and Early Clinical Development of an Inhibitor of 5‑Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease von Pettersen, Daniel, Broddefalk, Johan, Emtenäs, Hans, Hayes, Martin A, Lemurell, Malin, Swanson, Marianne, Ulander, Johan, Whatling, Carl, Amilon, Carl, Ericsson, Hans, Westin Eriksson, Annika, Granberg, Kenneth, Plowright, Alleyn T, Shamovsky, Igor, Dellsèn, Anita, Sundqvist, Monica, Någård, Mats, Lindstedt, Eva-Lotte

Volltext

Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists von Cooper, Martin, Llinas, Antonio, Hansen, Peter, Caffrey, Moya, Ray, Asim, Sjödin, Stina, Shamovsky, Igor, Wada, Hiroki, Jellesmark Jensen, Tina, Sivars, Ulf, Hultin, Leif, Andersson, Ulf, Lundqvist, Sara, Gedda, Karin, Jinton, Lisa, Krutrök, Nina, Lewis, Richard, Jansson, Paul, Gardelli, Cristina

Volltext

Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin von Narjes, Frank, Edfeldt, Fredrik, Petersen, Jens, Öster, Linda, Hamblet, Corinne, Bird, James, Bold, Peter, Rae, Rebecca, Bäck, Elisabeth, Stomilovic, Stina, Zlatoidsky, Pavol, Svensson, Tor, Hidestål, Lotta, Kunalingam, Lavaniya, Shamovsky, Igor, De Maria, Leonardo, Gordon, Euan, Lewis, Richard J., Watcham, Sophie, van Rietschoten, Katerine, Mudd, Gemma E., Harrison, Helen, Chen, Liuhong, Skynner, Michael J.

Volltext

Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling von Shamovsky, Igor, Belfield, Graham, Lewis, Richard, Narjes, Frank, Ripa, Lena, Tyrchan, Christian, Öberg, Lisa, Sjö, Peter

Volltext

Theoretical Studies of the Mechanism of N‑Hydroxylation of Primary Aromatic Amines by Cytochrome P450 1A2: Radicaloid or Anionic? von Ripa, Lena, Mee, Christine, Sjö, Peter, Shamovsky, Igor

Volltext

Identification and Pharmacological Profile of an Indane Based Series of Ghrelin Receptor Full Agonists von Gardelli, Cristina, Wada, Hiroki, Ray, Asim, Caffrey, Moya, Llinas, Antonio, Shamovsky, Igor, Tholander, Joakim, Larsson, Joakim, Sivars, Ulf, Hultin, Leif, Andersson, Ulf, Sanganee, Hitesh J, Stenvall, Kristina, Leidvik, Brith, Gedda, Karin, Jinton, Lisa, Rydén Landergren, Marie, Karabelas, Kostas

Volltext

Explanation for Main Features of Structure–Genotoxicity Relationships of Aromatic Amines by Theoretical Studies of Their Activation Pathways in CYP1A2 von Shamovsky, Igor, Ripa, Lena, Börjesson, Lena, Mee, Christine, Nordén, Bo, Hansen, Peter, Hasselgren, Catrin, O’Donovan, Mike, Sjö, Peter

Volltext

The binding of zinc and copper ions to nerve growth factor is differentially affected by pH: implications for cerebral acidosis von Ross, Gregory M., Shamovsky, Igor L., Woo, Sang B., Post, Joan I., Vrkljan, Philip N., Lawrance, Gail, Solc, Mark, Dostaler, Suzanne M., Neet, Kenneth E., Riopelle, Richard J.

Volltext

Overcoming Undesirable hERG Potency of Chemokine Receptor Antagonists Using Baseline Lipophilicity Relationships von Shamovsky, Igor, Connolly, Stephen, David, Laurent, Ivanova, Svetlana, Nordén, Bo, Springthorpe, Brian, Urbahns, Klaus

Volltext

Fragment-Based Discovery of Novel Allosteric MEK1 Binders von Di Fruscia, Paolo, Edfeldt, Fredrik, Shamovsky, Igor, Collie, Gavin W, Aagaard, Anna, Barlind, Louise, Börjesson, Ulf, Hansson, Eva L, Lewis, Richard J, Nilsson, Magnus K, Öster, Linda, Pemberton, Josefine, Ripa, Lena, Storer, R. Ian, Käck, Helena

Volltext

Theoretical and Biochemical Studies on the Selectivity of Nerve Growth Factor for Transition Metal Cations von Shamovsky, Igor L, Ross, Gregory M, Riopelle, Richard J, Weaver, Donald F

Volltext

Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins von Ross, Gregory M., Shamovsky, Igor L., Lawrance, Gail, Solc, Mark, Dostaler, Suzanne M., Jimmo, Sandra L., Weaver, Donald F., Riopelle, Richard J.

Volltext

Differential effects of transition metal cations on the conformation and biological activities of nerve growth factor von Maitra, Rajatavo, Shamovsky, Igor L., Wang, Wei, Solc, Mark, Lawrance, Gail, Dostaler, Suzanne M., Ross, Gregory M., Riopelle, Richard J.

Volltext

Theoretical Studies on the Bioactive Conformation of Nerve Growth Factor Using VBMCA Novel Variable Basis Monte Carlo Simulated Annealing Algorithm for Peptides von Shamovsky, Igor L, Ross, Gregory M, Riopelle, Richard J, Weaver, Donald F

Volltext