Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases von Lesslie, D P, Summy, J M, Parikh, N U, Fan, F, Trevino, J G, Sawyer, T K, Metcalf, C A, Shakespeare, W C, Hicklin, D J, Ellis, L M, Gallick, G E

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Modulation of Receptor and Receptor Subtype Affinities Using Diastereomeric and Enantiomeric Monosaccharide Scaffolds as a Means to Structural and Biological Diversity. A New Route... von Hirschmann, Ralph, Hynes, John, Cichy-Knight, Maria A, van Rijn, Rachel D, Sprengeler, Paul A, Spoors, P. Grant, Shakespeare, William C, Pietranico-Cole, Sherrie, Barbosa, Joseph, Liu, Josephine, Yao, Wenqing, Rohrer, Susan, Smith, Amos B

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Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption von Violette, S.M, Guan, W, Bartlett, C, Smith, J.A, Bardelay, C, Antoine, E, Rickles, R.J, Mandine, E, van Schravendijk, M.R, Adams, S.E, Lynch, B.A, Shakespeare, W.C, Yang, M, Jacobsen, V.A, Takeuchi, C.S, Macek, K.J, Bohacek, R.S, Dalgarno, D.C, Weigele, M, Lesuisse, D, Sawyer, T.K, Baron, R

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SH2 domain inhibition: a problem solved? von Shakespeare, William C

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X-ray Structure of Citrate Bound to Src SH2 Leads to a High-Affinity, Bone-Targeted Src SH2 Inhibitor von Bohacek, Regine S, Dalgarno, David C, Hatada, Marcos, Jacobsen, Virginia A, Lynch, Berkley A, Macek, Karina J, Merry, Taylor, Metcalf, Chester A, Narula, Surinder S, Sawyer, Tomi K, Shakespeare, William C, Violette, Shelia M, Weigele, Manfred

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AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance von O'Hare, Thomas, Shakespeare, William C., Zhu, Xiaotian, Eide, Christopher A., Rivera, Victor M., Wang, Frank, Adrian, Lauren T., Zhou, Tianjun, Huang, Wei-Sheng, Xu, Qihong, Metcalf, Chester A., Tyner, Jeffrey W., Loriaux, Marc M., Corbin, Amie S., Wardwell, Scott, Ning, Yaoyu, Keats, Jeffrey A., Wang, Yihan, Sundaramoorthi, Raji, Thomas, Mathew, Zhou, Dong, Snodgrass, Joseph, Commodore, Lois, Sawyer, Tomi K., Dalgarno, David C., Deininger, Michael W.N., Druker, Brian J., Clackson, Tim

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Structure-Based Design of Novel Bicyclic Nonpeptide Inhibitors for the Src SH2 Domain von Shakespeare, William C, Bohacek, Regine S, Azimioara, Mihai D, Macek, Karina J, Luke, George P, Dalgarno, David C, Hatada, Marcos H, Lu, Xiaode, Violette, Shelia M, Bartlett, Catherine, Sawyer, Tomi K

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An efficient synthesis of a 4′-phosphonodifluoromethyl-3′-formyl-phenylalanine containing Src SH2 ligand von Shakespeare, William C., Bohacek, Regine S., Narula, Surinder S., Azimioara, Mihai D., Yuan, Ruth W., Dalgarno, David C., Madden, Laura, Botfield, Martyn C., Holt, Dennis A.

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The first design and synthesis of a steroidal peptidomimetic. The potential value of peptidomimetics in elucidating the bioactive conformation of peptide ligands von Hirschmann, Ralph, Sprengeler, Paul A, Kawasaki, Tomomi, Leahy, James W, Shakespeare, William C, Smith, Amos B

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A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain von Kawahata, N, Yang, M G, Luke, G P, Shakespeare, W C, Sundaramoorthi, R, Wang, Y, Johnson, D, Merry, T, Violette, S, Guan, W, Bartlett, C, Smith, J, Hatada, M, Lu, X, Dalgarno, D C, Eyermann, C J, Bohacek, R S, Sawyer, T K

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Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML von O'Hare, Thomas, Pollock, Roy, Stoffregen, Eric P., Keats, Jeffrey A., Abdullah, Omar M., Moseson, Erika M., Rivera, Victor M., Tang, Hao, Metcalf, Chester A., Bohacek, Regine S., Wang, Yihan, Sundaramoorthi, Raji, Shakespeare, William C., Dalgarno, David, Clackson, Tim, Sawyer, Tomi K., Deininger, Michael W., Druker, Brian J.

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Palladium-catalyzed coupling of lactams with bromobenzenes von Shakespeare, William C.

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De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing .beta.-D-glucose as a novel scaffolding von Hirschmann, Ralph, Nicolaou, K. C, Pietranico, Sherrie, Leahy, Ellen M, Salvino, Joseph, Arison, Byron, Cichy, Maria A, Spoors, P. Grant, Shakespeare, William C

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AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogate... von Summy, Justin M, Trevino, Jose G, Lesslie, Donald P, Baker, Cheryl H, Shakespeare, William C, Wang, Yihan, Sundaramoorthi, Raji, Metcalf, 3rd, Chester A, Keats, Jeffrey A, Sawyer, Tomi K, Gallick, Gary E

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In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit von Corbin, Amie S., Demehri, Shadmehr, Griswold, Ian J., Wang, Yihan, Metcalf, Chester A., Sundaramoorthi, Raji, Shakespeare, William C., Snodgrass, Joseph, Wardwell, Scott, Dalgarno, David, Iuliucci, John, Sawyer, Tomi K., Heinrich, Michael C., Druker, Brian J., Deininger, Michael W.N.

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Bone-Targeted 2,6,9-Trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases von Wang, Yihan, Metcalf, Chester A., Shakespeare, William C., Sundaramoorthi, Raji, Keenan, Terence P., Bohacek, Regine S., van Schravendijk, Marie Rose, Violette, Shiela M., Narula, Surinder S., Dalgarno, David C., Haraldson, Chad, Keats, Jeffrey, Liou, Shuenn, Mani, Ukti, Pradeepan, Selvi, Ram, Mary, Adams, Susan, Weigele, Manfred, Sawyer, Tomi K.

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Vascular endothelial growth factor receptor-I mediates migration of human colorectal carcinoma cells by activation of Src family kinases von LESSLIE, D. P, SUMMY, J. M, GALLICK, G. E, PARIKH, N. U, FAN, F, TREVINO, J. G, SAWYER, T. K, METCALF, C. A, SHAKESPEARE, W. C, HICKLIN, D. J, ELLIS, L. M

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1,2,3-cyclohexatriene and cyclohexen-3-yne: two new highly strained C6H6 isomers von Shakespeare, William C, Johnson, Richard P

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Bone-Targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues von Sundaramoorthi, Raji, Shakespeare, William C., Keenan, Terence P., Metcalf, Chester A., Wang, Yihan, Mani, Ukti, Taylor, Merry, Liu, Shuangying, Bohacek, Regine S., Narula, Surinder S., Dalgarno, David C., Van Schravandijk, Marie Rose, Violette, Sheila M., Liou, Shuenn, Adams, Susan, Ram, Mary K., Keats, Jeffrey A., Weigele, Manfred, Sawyer, Tomi K.

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A Src SH2 selective binding compound inhibits osteoclast-mediated resorption von Violette, Shelia M, Shakespeare, William C, Bartlett, Catherine, Guan, Wei, Smith, Jeremy A, Rickles, Richard J, Bohacek, Regine S, Holt, Dennis A, Baron, Roland, Sawyer, Tomi K

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