Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells von Daher, May, Basar, Rafet, Gokdemir, Elif, Baran, Natalia, Uprety, Nadima, Nunez Cortes, Ana Karen, Mendt, Mayela, Kerbauy, Lucila Nassif, Banerjee, Pinaki P., Shanley, Mayra, Imahashi, Nobuhiko, Li, Li, Lim, Francesca Lorraine Wei Inng, Fathi, Mohsen, Rezvan, Ali, Mohanty, Vakul, Shen, Yifei, Shaim, Hila, Lu, Junjun, Ozcan, Gonca, Ensley, Emily, Kaplan, Mecit, Nandivada, Vandana, Bdiwi, Mustafa, Acharya, Sunil, Xi, Yuanxin, Wan, Xinhai, Mak, Duncan, Liu, Enli, Jiang, Xin Ru, Ang, Sonny, Muniz-Feliciano, Luis, Li, Ye, Wang, Jing, Kordasti, Shahram, Petrov, Nedyalko, Varadarajan, Navin, Marin, David, Brunetti, Lorenzo, Skinner, Richard J., Lyu, Shangrong, Silva, Leiser, Turk, Rolf, Schubert, Mollie S., Rettig, Garrett R., McNeill, Matthew S., Kurgan, Gavin, Behlke, Mark A., Li, Heng, Fowlkes, Natalie W., Chen, Ken, Konopleva, Marina, Champlin, Richard E., Shpall, Elizabeth J., Rezvani, Katayoun

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Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD von Khoder, Ahmad, Sarvaria, Anushruti, Alsuliman, Abdullah, Chew, Claude, Sekine, Takuya, Cooper, Nichola, Mielke, Stephan, de Lavallade, Hugues, Muftuoglu, Muharrem, Fernandez Curbelo, Irina, Liu, Enli, Muraro, Paolo A., Alousi, Amin, Stringaris, Kate, Parmar, Simrit, Shah, Nina, Shaim, Hila, Yvon, Eric, Molldrem, Jeffrey, Rouce, Rayne, Champlin, Richard, McNiece, Ian, Mauri, Claudia, Shpall, Elizabeth J., Rezvani, Katayoun

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IL-10+ regulatory B cells are enriched in cord blood and may protect against cGVHD after cord blood transplantation von Sarvaria, Anushruti, Basar, Rafet, Mehta, Rohtesh S., Shaim, Hila, Muftuoglu, Muharrem, Khoder, Ahmad, Sekine, Takuye, Gokdemir, Elif, Kondo, Kayo, Marin, David, Daher, May, Alousi, Amin M., Alsuliman, Abdullah, Liu, Enli, Oran, Betul, Olson, Amanda, Jones, Roy B., Popat, Uday, Hosing, Chitra, Champlin, Richard, Shpall, Elizabeth J., Rezvani, Katayoun

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Specific combinations of donor and recipient KIR-HLA genotypes predict for large differences in outcome after cord blood transplantation von Sekine, Takuya, Marin, David, Cao, Kai, Li, Li, Mehta, Pramod, Shaim, Hila, Sobieski, Catherine, Jones, Roy, Oran, Betul, Hosing, Chitra, Rondon, Gabriela, Alsuliman, Abdullah, Paust, Silke, Andersson, Borje, Popat, Uday, Kebriaei, Partow, Muftuoglu, Muharrem, Basar, Rafet, Kondo, Kayo, Nieto, Yago, Shah, Nina, Olson, Amanda, Alousi, Amin, Liu, Enli, Sarvaria, Anushruti, Parmar, Simrit, Armstrong-James, Darius, Imahashi, Nobuhiko, Molldrem, Jeffrey, Champlin, Richard, Shpall, Elizabeth J., Rezvani, Katayoun

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GMP-Compliant Universal Antigen Presenting Cells (uAPC) Promote the Metabolic Fitness and Antitumor Activity of Armored Cord Blood CAR-NK Cells von Liu, Enli, Ang, Sonny O. T., Kerbauy, Lucila, Basar, Rafet, Kaur, Indreshpal, Kaplan, Mecit, Li, Li, Tong, Yijiu, Daher, May, Ensley, Emily L., Uprety, Nadima, Nunez Cortes, Ana Karen, Yang, Ryan Z., Li, Ye, Shaim, Hila, Reyes Silva, Francia, Lin, Paul, Mohanty, Vakul, Acharya, Sunil, Shanley, Mayra, Muniz-Feliciano, Luis, Banerjee, Pinaki P., Chen, Ken, Champlin, Richard E., Shpall, Elizabeth J., Rezvani, Katayoun

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UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells von Samudio, Ismael, Rezvani, Katayoun, Shaim, Hila, Hofs, Elyse, Ngom, Mor, Bu, Luke, Liu, Guoyu, Lee, Jason T.C., Imren, Suzan, Lam, Vivian, Poon, Grace F.T., Ghaedi, Maryam, Takei, Fumio, Humphries, Keith, Jia, William, Krystal, Gerald

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Evidence for B Cell Exhaustion in Chronic Graft-versus-Host Disease von Khoder, Ahmad, Alsuliman, Abdullah, Basar, Rafet, Sobieski, Catherine, Kondo, Kayo, Alousi, Amin Majid, Szydlo, Richard, Muftuoglu, Muharrem, Shaim, Hila, Apperley, Jane F, Gokdemir, Elif, Cooper, Nichola, Mehta, Rohtesh S, Marin, David, Champlin, Richard, Shpall, Elizabeth, Rezvani, Katayoun

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Metabolic Reprogramming of GMP Grade Cord Tissue Derived Mesenchymal Stem Cells Enhances Their Suppressive Potential in GVHD von Mendt, Mayela, Daher, May, Basar, Rafet, Shanley, Mayra, Kumar, Bijender, Wei Inng, Francesca Lim, Acharya, Sunil, Shaim, Hila, Fowlkes, Natalie, Tran, Jamie P., Gokdemir, Elif, Uprety, Nadima, Nunez-Cortes, Ana K., Ensley, Emily, Mai, Thao, Kerbauy, Lucila N., Melo-Garcia, Luciana, Lin, Paul, Shen, Yifei, Mohanty, Vakul, Lu, JunJun, Li, Sufang, Nandivada, Vandana, Wang, Jing, Banerjee, Pinaki, Reyes-Silva, Francia, Liu, Enli, Ang, Sonny, Gilbert, April, Li, Ye, Wan, Xinhai, Gu, Jun, Zhao, Ming, Baran, Natalia, Muniz-Feliciano, Luis, Wilson, Jeffrey, Kaur, Indreshpal, Gagea, Mihai, Konopleva, Marina, Marin, David, Tang, Guilin, Chen, Ken, Champlin, Richard, Rezvani, Katayoun, Shpall, Elizabeth J.

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The CXCR4-STAT3-IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide von Shaim, Hila, Estrov, Zeev, Harris, David, Hernandez Sanabria, Mayra, Liu, Zhiming, Ruvolo, Peter, Thompson, Phillip A, Ferrajoli, Alessandra, Daher, May, Burger, Jan, Muftuoglu, Muharrem, Imahashi, Nobuhiko, Li, Li, Liu, Enli, Alsuliman, Abdullah Saleh, Basar, Rafet, Nassif Kerbauy, Lucila, Sobieski, Catherine, Gokdemir, Elif, Kondo, Kayo, Wierda, William, Keating, Michael, Shpall, Elizabeth J, Rezvani, Katayoun

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Activated B cells suppress T-cell function through metabolic competition von Imahashi, Nobuhiko, Basar, Rafet, Huang, Yuefan, Wang, Fang, Baran, Natalia, Banerjee, Pinaki Prosad, Lu, Junjun, Nunez Cortes, Ana Karen, Uprety, Nadima, Ensley, Emily, Muniz-Feliciano, Luis, Laskowski, Tamara J, Moyes, Judy S, Daher, May, Mendt, Mayela, Kerbauy, Lucila N, Shanley, Mayra, Li, Li, Lim, Francesca Lorraine Wei Inng, Shaim, Hila, Li, Ye, Konopleva, Marina, Green, Michael, Wargo, Jennifer, Shpall, Elizabeth J, Chen, Ken, Rezvani, Katayoun

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A novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation von Li, Li, Chen, Han, Marin, David, Xi, Yuanxin, Miao, Qi, Lv, Jiangxing, Banerjee, Pinaki Prosad, Shaim, Hila, Daher, May, Basar, Rafet, Imahashi, Nobuhiko, Jimenez, Juan, Hu, Bingqian, Mehta, Rohtesh S., Kerbauy, Lucila Nassif, Kaplan, Mecit, Mendt, Mayela, Ozcan, Gonca, Gokdemir, Elif, Hernandez Sanabria, Mayra, Li, Ye, Chen, Ken, Wang, Jing, Muniz-Feliciano, Luis, Zhao, Wei-Li, Champlin, Richard E., Shpall, Elizabeth J., Rezvani, Katayoun

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Cord blood: a promising source of allogeneic natural killer cells for immunotherapy von Shaim, Hila, Yvon, Eric

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531 AFM13-targeted blood and cord-blood-derived memory-like NK cells as therapy for CD30+ malignancies von Kerbauy, Lucila, Marin, Nancy, Kaplan, Mecit, Banerjee, Pinaki, Berrien-Elliott, Melissa, Becker-Hapak, Michelle, Basar, Rafet, Foster, Mark, Melo, Luciana Garcia, Neal, Carly, McClain, Ethan, Daher, May, Nunez Cortes, Ana Karen, Desai, Sweta, Inng Lim, Francesca Wei, Mendt, Mayela Carolina, Schappe, Timothy, Li, Li, Shaim, Hila, Sanabria, Mayra Hernandez, Wong, Pamela, Liu, Enli, Ang, Sonny, Cai, Rong, Nandivada, Vandana, Mohanty, Vakul, Shen, Yifei, Baran, Natalia, Fowlkes, Natalie, Chen, Ken, Muniz-Feliciano, Luis, Koch, Joachim, Treder, Martin, Fischer, Wolfgang, Okamoto, Oswaldo Keith, Nieto, Yago, Champlin, Richard, Shpall, Elizabeth, Fehniger, Todd, Rezvani, Katy

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Targeting the alpha v integrin/TGF-beta axis improves natural killer cell function against glioblastoma stem cells von Shaim, Hila, Shanley, Mayra, Basar, Rafet, Daher, May, Gumin, Joy, Zamler, Daniel B., Uprety, Nadima, Wang, Fang, Huang, Yuefan, Gabrusiewicz, Konrad, Miao, Qi, Dou, Jinzhuang, Alsuliman, Abdullah, Kerbauy, Lucila N., Acharya, Sunil, Mohanty, Vakul, Mendt, Mayela, Li, Sufang, Lu, JunJun, Wei, Jun, Fowlkes, Natalie W., Gokdemir, Elif, Ensley, Emily L., Kaplan, Mecit, Kassab, Cynthia, Li, Li, Ozcan, Gonca, Banerjee, Pinaki P., Shen, Yifei, Gilbert, April L., Jones, Corry M., Bdiwi, Mustafa, Nunez-Cortes, Ana K., Liu, Enli, Yu, Jun, Imahashi, Nobuhiko, Muniz-Feliciano, Luis, Li, Ye, Hu, Jian, Draetta, Giulio, Marin, David, Yu, Dihua, Mielke, Stephan, Eyrich, Matthias, Champlin, Richard E., Chen, Ken, Lang, Frederick F., Shpall, Elizabeth J., Heimberger, Amy B., Rezvani, Katayoun

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Phase I study of cord blood‐derived natural killer cells combined with autologous stem cell transplantation in multiple myeloma von Shah, Nina, Li, Li, McCarty, Jessica, Kaur, Indreshpal, Yvon, Eric, Shaim, Hila, Muftuoglu, Muharrem, Liu, Enli, Orlowski, Robert Z., Cooper, Laurence, Lee, Dean, Parmar, Simrit, Cao, Kai, Sobieiski, Catherine, Saliba, Rima, Hosing, Chitra, Ahmed, Sairah, Nieto, Yago, Bashir, Qaiser, Patel, Krina, Bollard, Catherine, Qazilbash, Muzaffar, Champlin, Richard, Rezvani, Katy, Shpall, Elizabeth J.

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The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia von Rouce, R H, Shaim, H, Sekine, T, Weber, G, Ballard, B, Ku, S, Barese, C, Murali, V, Wu, M-F, Liu, H, Shpall, E J, Bollard, C M, Rabin, K R, Rezvani, K

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Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway von Kondo, K, Shaim, H, Thompson, P A, Burger, J A, Keating, M, Estrov, Z, Harris, D, Kim, E, Ferrajoli, A, Daher, M, Basar, R, Muftuoglu, M, Imahashi, N, Alsuliman, A, Sobieski, C, Gokdemir, E, Wierda, W, Jain, N, Liu, E, Shpall, E J, Rezvani, K

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Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma von Kirschenbaum, Daniel, Xie, Ken, Ingelfinger, Florian, Katzenelenbogen, Yonatan, Abadie, Kathleen, Look, Thomas, Sheban, Fadi, Phan, Truong San, Li, Baoguo, Zwicky, Pascale, Yofe, Ido, David, Eyal, Mazuz, Kfir, Hou, Jinchao, Chen, Yun, Shaim, Hila, Shanley, Mayra, Becker, Soeren, Qian, Jiawen, Colonna, Marco, Ginhoux, Florent, Rezvani, Katayoun, Theis, Fabian J, Yosef, Nir, Weiss, Tobias, Weiner, Assaf, Amit, Ido

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Sa1577 THE ROLE OF INTRAVENOUS VITAMIN K IN THE CORRECTION OF CIRRHOSIS-ASSOCIATED COAGULOPATHY von Shaim, Hila, Abdul-Baki, Kian, Malone, Jordan C., Chowdhury, Anni, Butt, Edward, Ameri, Moe, Shofner, Daniel, Lee, Marissa, Patel, Milee, Bhakta, Pooja, Antony, Michael, McCaffrey, Peter, Yates, Sean

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Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood-Derived NK Cells Facilitates CAR-like Responses Against CD30(+) Malignancies von Kerbauy, Lucila N., Marin, Nancy D., Kaplan, Mecit, Banerjee, Pinaki P., Berrien-Elliott, Melissa M., Becker-Hapak, Michelle, Basar, Rafet, Foster, Mark, Melo, Luciana Garcia, Neal, Carly C., McClain, Ethan, Daher, May, Cortes, Ana Karen Nunez, Desai, Sweta, Lim, Francesca Wei Inng, Mendt, Mayela Carolina, Schappe, Timothy, Li, Li, Shaim, Hila, Shanley, Mayra, Ensley, Emily L., Uprety, Nadima, Wong, Pamela, Liu, Enli, Ang, Sonny O., Cai, Rong, Nandivada, Vandana, Mohanty, Vakul, Miao, Qi, Shen, Yifei, Baran, Natalia, Fowlkes, Natalie W., Chen, Ken, Muniz-Feliciano, Luis, Champlin, Richard E., Nieto, Yago L., Koch, Joachim, Treder, Martin, Fischer, Wolfgang, Okamoto, Oswaldo Keith, Shpall, Elizabeth J., Fehniger, Todd A., Rezvani, Katayoun

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