Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer von Kamran, Sophia C, Lennerz, Jochen K, Margolis, Claire A, Liu, David, Reardon, Brendan, Wankowicz, Stephanie A, Van Seventer, Emily E, Tracy, Adam, Wo, Jennifer Y, Carter, Scott L, Willers, Henning, Corcoran, Ryan B, Hong, Theodore S, Van Allen, Eliezer M

Volltext

Percentile‐based averaging and skeletal muscle gauge improve body composition analysis: validation at multiple vertebral levels von Marquardt, J. Peter, Roeland, Eric J., Van Seventer, Emily E., Best, Till D., Horick, Nora K., Nipp, Ryan D., Fintelmann, Florian J.

Volltext

Mycobacteria induce TPL-2 mediated IL-10 in IL-4-generated alternatively activated macrophages von Chatterjee, Soumya, Talaat, Kawsar R, van Seventer, Emily E, Feng, Carl G, Scott, Alan L, Jedlicka, Anne, Dziedzic, Amanda, Nutman, Thomas B

Volltext

Resistance to checkpoint blockade therapy through inactivation of antigen presentation von Sade-Feldman, Moshe, Jiao, Yunxin J., Chen, Jonathan H., Rooney, Michael S., Barzily-Rokni, Michal, Eliane, Jean-Pierre, Bjorgaard, Stacey L., Hammond, Marc R., Vitzthum, Hans, Blackmon, Shauna M., Frederick, Dennie T., Hazar-Rethinam, Mehlika, Nadres, Brandon A., Van Seventer, Emily E., Shukla, Sachet A., Yizhak, Keren, Ray, John P., Rosebrock, Daniel, Livitz, Dimitri, Adalsteinsson, Viktor, Getz, Gad, Duncan, Lyn M., Li, Bo, Corcoran, Ryan B., Lawrence, Donald P., Stemmer-Rachamimov, Anat, Boland, Genevieve M., Landau, Dan A., Flaherty, Keith T., Sullivan, Ryan J., Hacohen, Nir

Volltext

Response to Anti-EGFR Therapy in Patients with BRAF non-V600-Mutant Metastatic Colorectal Cancer von Yaeger, Rona, Kotani, Daisuke, Mondaca, Sebastián, Parikh, Aparna R, Bando, Hideaki, Van Seventer, Emily E, Taniguchi, Hiroya, Zhao, HuiYong, Thant, Claire N, de Stanchina, Elisa, Rosen, Neal, Corcoran, Ryan B, Yoshino, Takayuki, Yao, Zhan, Ebi, Hiromichi

Volltext

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine von Aguirre, Andrew J, Nowak, Jonathan A, Camarda, Nicholas D, Moffitt, Richard A, Ghazani, Arezou A, Hazar-Rethinam, Mehlika, Raghavan, Srivatsan, Kim, Jaegil, Brais, Lauren K, Ragon, Dorisanne, Welch, Marisa W, Reilly, Emma, McCabe, Devin, Marini, Lori, Anderka, Kristin, Helvie, Karla, Oliver, Nelly, Babic, Ana, Da Silva, Annacarolina, Nadres, Brandon, Van Seventer, Emily E, Shahzade, Heather A, St Pierre, Joseph P, Burke, Kelly P, Clancy, Thomas, Cleary, James M, Doyle, Leona A, Jajoo, Kunal, McCleary, Nadine J, Meyerhardt, Jeffrey A, Murphy, Janet E, Ng, Kimmie, Patel, Anuj K, Perez, Kimberly, Rosenthal, Michael H, Rubinson, Douglas A, Ryou, Marvin, Shapiro, Geoffrey I, Sicinska, Ewa, Silverman, Stuart G, Nagy, Rebecca J, Lanman, Richard B, Knoerzer, Deborah, Welsch, Dean J, Yurgelun, Matthew B, Fuchs, Charles S, Garraway, Levi A, Getz, Gad, Hornick, Jason L, Johnson, Bruce E, Kulke, Matthew H, Mayer, Robert J, Miller, Jeffrey W, Shyn, Paul B, Tuveson, David A, Wagle, Nikhil, Yeh, Jen Jen, Hahn, William C, Corcoran, Ryan B, Carter, Scott L, Wolpin, Brian M

Volltext

Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer von Parikh, Aparna R, Van Seventer, Emily E, Siravegna, Giulia, Hartwig, Anna V, Jaimovich, Ariel, He, Yupeng, Kanter, Katie, Fish, Madeleine G, Fosbenner, Kathryn D, Miao, Benchun, Phillips, Susannah, Carmichael, John H, Sharma, Nihaarika, Jarnagin, Joy, Baiev, Islam, Shah, Yojan S, Fetter, Isobel J, Shahzade, Heather A, Allen, Jill N, Blaszkowsky, Lawrence S, Clark, Jeffrey W, Dubois, Jon S, Franses, Joseph W, Giantonio, Bruce J, Goyal, Lipika, Klempner, Samuel J, Nipp, Ryan D, Roeland, Eric J, Ryan, David P, Weekes, Colin D, Wo, Jennifer Y, Hong, Theodore S, Bordeianou, Liliana, Ferrone, Cristina R, Qadan, Motaz, Kunitake, Hiroko, Berger, David, Ricciardi, Rocco, Cusack, James C, Raymond, Victoria M, Talasaz, AmirAli, Boland, Genevieve M, Corcoran, Ryan B

Volltext

Serial ctDNA Monitoring to Predict Response to Systemic Therapy in Metastatic Gastrointestinal Cancers von Parikh, Aparna R, Mojtahed, Amikasra, Schneider, Jaime L, Kanter, Katie, Van Seventer, Emily E, Fetter, Isobel J, Thabet, Ashraf, Fish, Madeleine G, Teshome, Bezaye, Fosbenner, Kathryn, Nadres, Brandon, Shahzade, Heather A, Allen, Jill N, Blaszkowsky, Lawrence S, Ryan, David P, Giantonio, Bruce, Goyal, Lipika, Nipp, Ryan D, Roeland, Eric, Weekes, Colin D, Wo, Jennifer Y, Zhu, Andrew X, Dias-Santagata, Dora, Iafrate, A John, Lennerz, Jochen K, Hong, Theodore S, Siravegna, Giulia, Horick, Nora, Clark, Jeffrey W, Corcoran, Ryan B

Volltext

TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma von Goyal, Lipika, Shi, Lei, Liu, Leah Y, Fece de la Cruz, Ferran, Lennerz, Jochen K, Raghavan, Srivatsan, Leschiner, Ignaty, Elagina, Liudmila, Siravegna, Giulia, Ng, Raymond W S, Vu, Phuong, Patra, Krushna C, Saha, Supriya K, Uppot, Raul N, Arellano, Ron, Reyes, Stephanie, Sagara, Takeshi, Otsuki, Sachie, Nadres, Brandon, Shahzade, Heather A, Dey-Guha, Ipsita, Fetter, Isobel J, Baiev, Islam, Van Seventer, Emily E, Murphy, Janet E, Ferrone, Cristina R, Tanabe, Kenneth K, Deshpande, Vikram, Harding, James J, Yaeger, Rona, Kelley, Robin K, Bardelli, Alberto, Iafrate, A John, Hahn, William C, Benes, Cyril H, Ting, David T, Hirai, Hiroshi, Getz, Gad, Juric, Dejan, Zhu, Andrew X, Corcoran, Ryan B, Bardeesy, Nabeel

Volltext

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma von Goyal, Lipika, Saha, Supriya K, Liu, Leah Y, Siravegna, Giulia, Leshchiner, Ignaty, Ahronian, Leanne G, Lennerz, Jochen K, Vu, Phuong, Deshpande, Vikram, Kambadakone, Avinash, Mussolin, Benedetta, Reyes, Stephanie, Henderson, Laura, Sun, Jiaoyuan Elisabeth, Van Seventer, Emily E, Gurski, Jr, Joseph M, Baltschukat, Sabrina, Schacher-Engstler, Barbara, Barys, Louise, Stamm, Christelle, Furet, Pascal, Ryan, David P, Stone, James R, Iafrate, A John, Getz, Gad, Porta, Diana Graus, Tiedt, Ralph, Bardelli, Alberto, Juric, Dejan, Corcoran, Ryan B, Bardeesy, Nabeel, Zhu, Andrew X

Volltext

Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAFV600E Colorectal Cancer von Hazar-Rethinam, Mehlika, Kleyman, Marianna, Han, G Celine, Liu, David, Ahronian, Leanne G, Shahzade, Heather A, Chen, Lifeng, Parikh, Aparna R, Allen, Jill N, Clark, Jeffrey W, Kwak, Eunice L, Faris, Jason E, Murphy, Janet E, Hong, Theodore S, Van Seventer, Emily E, Nadres, Brandon, Hong, Catriona B, Gurski, Joseph M, Jessop, Nicholas A, Dias-Santagata, Dora, Iafrate, A John, Van Allen, Eliezer M, Corcoran, Ryan B

Volltext

Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial von Tian, Jun, Chen, Jonathan H., Chao, Sherry X., Pelka, Karin, Giannakis, Marios, Hess, Julian, Burke, Kelly, Jorgji, Vjola, Sindurakar, Princy, Braverman, Jonathan, Mehta, Arnav, Oka, Tomonori, Huang, Mei, Lieb, David, Spurrell, Maxwell, Allen, Jill N., Abrams, Thomas A., Clark, Jeffrey W., Enzinger, Andrea C., Enzinger, Peter C., Klempner, Samuel J., McCleary, Nadine J., Meyerhardt, Jeffrey A., Ryan, David P., Yurgelun, Matthew B., Kanter, Katie, Van Seventer, Emily E., Baiev, Islam, Chi, Gary, Jarnagin, Joy, Bradford, William B., Wong, Edmond, Michel, Alexa G., Fetter, Isobel J., Siravegna, Giulia, Gemma, Angelo J., Sharpe, Arlene, Demehri, Shadmehr, Leary, Rebecca, Campbell, Catarina D., Yilmaz, Omer, Getz, Gad A., Parikh, Aparna R., Hacohen, Nir, Corcoran, Ryan B.

Volltext

Serial assessment of cell-free circulating tumor DNA (ctDNA) to assess treatment effect and minimal residual disease during neoadjuvant and adjuvant therapy in colorectal cancer von Parikh, A., Van Seventer, E., Boland, G., Hartwig, A., Jaimovich, A., Raymond, V., Talasaz, A., Corcoran, R.

Volltext

Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial von Parikh, Aparna R, Szabolcs, Annamaria, Allen, Jill N, Clark, Jeffrey W, Wo, Jennifer Y, Raabe, Michael, Thel, Hannah, Hoyos, David, Mehta, Arnav, Arshad, Sanya, Lieb, David J, Drapek, Lorraine C, Blaszkowsky, Lawrence S, Giantonio, Bruce J, Weekes, Colin D, Zhu, Andrew X, Goyal, Lipika, Nipp, Ryan D, Dubois, Jon S, Van Seventer, Emily E, Foreman, Bronwen E, Matlack, Lauren E, Ly, Leilana, Meurer, Jessica A, Hacohen, Nir, Ryan, David P, Yeap, Beow Y, Corcoran, Ryan B, Greenbaum, Benjamin D, Ting, David T, Hong, Theodore S

Volltext

Leveraging the Potential Synergy Between Patient‐Reported Outcomes and Body Composition Analysis in Patients with Cancer von Seventer, Emily E., Fintelmann, Florian J., Roeland, Eric J., Nipp, Ryan D.

Volltext

SO-26 Clinical efficacy of combined BRAF, MEK, and PD-1 inhibition in BRAFV600E colorectal cancer patients von Corcoran, R., Giannakis, M., Allen, J., Chen, J., Pelka, K., Chao, S., Meyerhardt, J., Enzinger, A., Enzinger, P., McCleary, N., Yugelun, M., Abrams, T., Kanter, K., Van Seventer, E., Bradford, W., Fetter, I., Siravegna, G., Tian, J., Clark, J., Ryan, D., Hacohen, N., Parikh, A.

Volltext

Proof of concept of the abscopal effect in MSS GI cancers: A phase 2 study of ipilimumab and nivolumab with radiation in metastatic pancreatic and colorectal adenocarcinoma von Parikh, A., Clark, J., Wo, J., Yeap, B., Allen, J., Blaszkowsky, L., Ryan, D., Giantonio, B., Weekes, C., Zhu, A., Van Seventer, E., Ly, L., Matlack, L., Foreman, B., Drapek, L., Ting, D., Corcoran, R., Hong, T.

Volltext

Serial circulating tumor DNA (ctDNA) monitoring to predict response to treatment in metastatic gastrointestinal cancers von Parikh, A., Kanter, K., Mojtahed, A., Schneider, J., Van Seventer, E., Fish, M., Allen, J., Blaszkowsky, L., Wo, J., Clark, J., Giantonio, B., Goyal, L., Hong, T., Nipp, R., Roeland, E., Weekes, C., Zhu, A., Ryan, D., Fetter, I., Horick, N., Corcoran, R.

Volltext

PARP-ness in metastatic colorectal cancer von Mauri, G., Kanter, K., Fish, M., Horick, N., Allen, J., Blaszkowsky, L., Clark, J., Ryan, D., Nipp, R., Giantonio, B., Goyal, L., Dubois, J., Murphy, J., Roeland, E., Weekes, C., Wo, J., Hong, T., Zhu, A., Van Seventer, E., Corcoran, R., Parikh, A.

Volltext

Associations of baseline patient‐reported outcomes with treatment outcomes in advanced gastrointestinal cancer von Seventer, Emily E., Fish, Madeleine G., Fosbenner, Kathryn, Kanter, Katie, Mojtahed, Amirkasra, Allen, Jill N., Blaszkowsky, Lawrence, Clark, Jeffrey W., Dubois, Jon, Franses, Joseph W., Giantonio, Bruce J., Goyal, Lipika, Klempner, Samuel J., Roeland, Eric J., Ryan, David P., Weekes, Colin D., Mulvey, Therese, El‐Jawahri, Areej, Horick, Nora, Corcoran, Ryan B., Parikh, Aparna R., Nipp, Ryan D.

Volltext