Mechanism of β2AR regulation by an intracellular positive allosteric modulator von Liu, Xiangyu, Masoudi, Ali, Kahsai, Alem W, Li-Yin, Huang, Pani Biswaranjan, Staus, Dean P, Shim, Paul J, Hirata Kunio, Simhal, Rishabh K, Schwalb, Allison M, Rambarat, Paula K, Ahn Seungkirl, Lefkowitz, Robert J, Kobilka, Brian

Volltext

Multiple ligand-specific conformations of the β2-adrenergic receptor von Kahsai, Alem W, Xiao, Kunhong, Rajagopal, Sudarshan, Ahn, Seungkirl, Shukla, Arun K, Sun, Jinpeng, Oas, Terrence G, Lefkowitz, Robert J

Volltext

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems von Li, Angus, Liu, Samuel, Huang, Rennica, Ahn, Seungkirl, Lefkowitz, Robert J

Volltext

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation von Staus, Dean P., Strachan, Ryan T., Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W., Kim, Tae Hun, Wingler, Laura M., Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C., Pardon, Els, Steyaert, Jan, Weis, William I., Prosser, R. Scott, Kobilka, Brian K., Costa, Tommaso, Lefkowitz, Robert J.

Volltext

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 von Luttrell, Louis M, Wang, Jialu, Plouffe, Bianca, Smith, Jeffrey S, Yamani, Lama, Kaur, Suneet, Jean-Charles, Pierre-Yves, Gauthier, Christophe, Lee, Mi-Hye, Pani, Biswaranjan, Kim, Jihee, Ahn, Seungkirl, Rajagopal, Sudarshan, Reiter, Eric, Bouvier, Michel, Shenoy, Sudha K, Laporte, Stéphane A, Rockman, Howard A, Lefkowitz, Robert J

Volltext

β-Arrestin- but Not G Protein-Mediated Signaling by the "Decoy" Receptor CXCR7 von Rajagopal, Sudarshan, Kim, Jihee, Ahn, Seungkirl, Craig, Stewart, Lam, Christopher M., Gerard, Norma P., Gerard, Craig, Lefkowitz, Robert J.

Volltext

G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor von Choi, Minjung, Staus, Dean P, Wingler, Laura M, Ahn Seungkirl, Pani Biswaranjan, Capel, William D, Lefkowitz, Robert J

Volltext

unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling von Wisler, James W, DeWire, Scott M, Whalen, Erin J, Violin, Jonathan D, Drake, Matthew T, Ahn, Seungkirl, Shenoy, Sudha K, Lefkowitz, Robert J

Volltext

Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library von Ahn, Seungkirl, Kahsai, Alem W., Pani, Biswaranjan, Wang, Qin-Ting, Zhao, Shuai, Wall, Alissa L., Strachan, Ryan T., Staus, Dean P., Wingler, Laura M., Sun, Lillian D., Sinnaeve, Justine, Choi, Minjung, Cho, Ted, Xu, Thomas T., Hansen, Gwenn M., Burnett, Michael B., Lamerdin, Jane E., Bassoni, Daniel L., Gavino, Bryant J., Husemoen, Gitte, Olsen, Eva K., Franch, Thomas, Costanzi, Stefano, Chen, Xin, Lefkowitz, Robert J.

Volltext

Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models von Ahn, Seungkirl, Maarsingh, Harm, Walker, Julia Kl, Liu, Samuel W, Hegde, Akhil, Sumajit, Hyeje C, Kahsai, Alem W, Lefkowitz, Robert J

Volltext

How carvedilol does not activate β2-adrenoceptors von Lefkowitz, Robert J., Rockman, Howard A., Shim, Paul J., Liu, Samuel, Ahn, Seungkirl, Pani, Biswaranjan, Rajagopal, Sudarshan, Shenoy, Sudha K., Bouvier, Michel, Benovic, Jeffrey L., Liggett, Stephen B., Ruffolo, Robert R., Bristow, Michael R., Packer, Milton

Volltext

β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2 von Shenoy, Sudha K, Modi, Aalok S, Shukla, Arun K, Xiao, Kunhong, Berthouze, Magali, Ahn, Seungkirl, Wilkinson, Keith D, Miller, William E, Lefkowitz, Robert J

Volltext

Different G Protein-Coupled Receptor Kinases Govern G Protein and β-Arrestin-Mediated Signaling of V2 Vasopressin Receptor von Ren, Xiu-Rong, Reiter, Eric, Ahn, Seungkirl, Kim, Jihee, Chen, Wei, Lefkowitz, Robert J.

Volltext

Functional Antagonism of Different G Protein-Coupled Receptor Kinases for β-Arrestin-Mediated Angiotensin II Receptor Signaling von Kim, Jihee, Ahn, Seungkirl, Ren, Xiu-Rong, Whalen, Erin J., Reiter, Eric, Wei, Huijun, Lefkowitz, Robert J.

Volltext

Independent β-Arrestin 2 and G Protein-Mediated Pathways for Angiotensin II Activation of Extracellular Signal-Regulated Kinases 1 and 2 von Wei, Huijun, Ahn, Seungkirl, Shenoy, Sudha K., Karnik, Sadashiva S., Hunyady, László, Luttrell, Louis M., Lefkowitz, Robert J.

Volltext

Competing G protein‐coupled receptor kinases balance G protein and β‐arrestin signaling von Heitzler, Domitille, Durand, Guillaume, Gallay, Nathalie, Rizk, Aurélien, Ahn, Seungkirl, Kim, Jihee, Violin, Jonathan D, Dupuy, Laurence, Gauthier, Christophe, Piketty, Vincent, Crépieux, Pascale, Poupon, Anne, Clément, Frédérique, Fages, François, Lefkowitz, Robert J, Reiter, Eric

Volltext

Src-mediated Tyrosine Phosphorylation of Dynamin Is Required for β2-Adrenergic Receptor Internalization and Mitogen-activated Protein Kinase Signaling von Ahn, Seungkirl, Maudsley, Stuart, Luttrell, Louis M., Lefkowitz, Robert J., Daaka, Yehia

Volltext

Desensitization, Internalization, and Signaling Functions of β-Arrestins Demonstrated by RNA Interference von Ahn, Seungkirl, Nelson, Christopher D., Garrison, Tiffany Runyan, Miller, William E., Lefkowitz, Robert J.

Volltext

Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure von Liu, Xiangyu, Ahn, Seungkirl, Kahsai, Alem W., Meng, Kai-Cheng, Latorraca, Naomi R., Pani, Biswaranjan, Venkatakrishnan, A. J., Masoudi, Ali, Weis, William I., Dror, Ron O., Chen, Xin, Lefkowitz, Robert J., Kobilka, Brian K.

Volltext

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor von Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K, Gawron, Sylwia, Sassano, Maria F, Kahsai, Alem W, Wingler, Laura M, Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D, Roth, Bryan L, Gilbert, Ian H, Hopkins, Andrew L, Lefkowitz, Robert J, Navratilova, Iva

Volltext