Lynch Syndrome Genetics and Clinical Implications von Peltomäki, Päivi, Nyström, Minna, Mecklin, Jukka-Pekka, Seppälä, Toni T.

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Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus von Pyykkö, Okko T, Lumela, Miikka, Rummukainen, Jaana, Nerg, Ossi, Seppälä, Toni T, Herukka, Sanna-Kaisa, Koivisto, Anne M, Alafuzoff, Irina, Puli, Lakshman, Savolainen, Sakari, Soininen, Hilkka, Jääskeläinen, Juha E, Hiltunen, Mikko, Zetterberg, Henrik, Leinonen, Ville

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Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer von Rajamäki, Kristiina, Taira, Aurora, Katainen, Riku, Välimäki, Niko, Kuosmanen, Anna, Plaketti, Roosa-Maria, Seppälä, Toni T., Ahtiainen, Maarit, Wirta, Erkki-Ville, Vartiainen, Emilia, Sulo, Päivi, Ravantti, Janne, Lehtipuro, Suvi, Granberg, Kirsi J., Nykter, Matti, Tanskanen, Tomas, Ristimäki, Ari, Koskensalo, Selja, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Taipale, Jussi, Mecklin, Jukka-Pekka, Aavikko, Mervi, Palin, Kimmo, Aaltonen, Lauri A.

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Editorial: Identification, risk stratification, and optimized management for Lynch Syndrome von Bernstein, Inge, Therkildsen, Christina, Seppälä, Toni T

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Epidemiological, clinical and molecular characterization of Lynch‐like syndrome: A population‐based study von Porkka, Noora, Lahtinen, Laura, Ahtiainen, Maarit, Böhm, Jan P., Kuopio, Teijo, Eldfors, Samuli, Mecklin, Jukka‐Pekka, Seppälä, Toni T., Peltomäki, Päivi

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Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome von Renkonen-Sinisalo, Laura, Seppälä, Toni T, Järvinen, Heikki J, Mecklin, Jukka-Pekka

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Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer von Seppälä, Toni T., Zimmerman, Jacquelyn W., Sereni, Elisabetta, Plenker, Dennis, Suri, Reecha, Rozich, Noah, Blair, Alex, Thomas, Dwayne L., Teinor, Jonathan, Javed, Ammar, Patel, Hardik, Cameron, John L., Burns, William R., He, Jin, Tuveson, David A., Jaffee, Elizabeth M., Eshleman, James, Szabolcs, Annamaria, Ryan, David P., Ting, David T., Wolfgang, Christopher L., Burkhart, Richard A.

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Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry von Zalevskaja, Kristina, Mecklin, Jukka-Pekka, Seppälä, Toni T

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Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response von Seppälä, Toni T, Zimmerman, Jacquelyn W, Suri, Reecha, Zlomke, Haley, Ivey, Gabriel D, Szabolcs, Annamaria, Shubert, Christopher R, Cameron, John L, Burns, William R, Lafaro, Kelly J, He, Jin, Wolfgang, Christopher L, Zou, Ying S, Zheng, Lei, Tuveson, David A, Eshlemann, James R, Ryan, David P, Kimmelman, Alec C, Hong, Theodore S, Ting, David T, Jaffee, Elizabeth M, Burkhart, Richard A

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The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance von Ahadova, Aysel, Seppälä, Toni T., Engel, Christoph, Gallon, Richard, Burn, John, Holinski‐Feder, Elke, Steinke‐Lange, Verena, Möslein, Gabriela, Nielsen, Maartje, Broeke, Sanne W., Laghi, Luigi, Dominguez‐Valentin, Mev, Capella, Gabriel, Macrae, Finlay, Scott, Rodney, Hüneburg, Robert, Nattermann, Jacob, Hoffmeister, Michael, Brenner, Hermann, Bläker, Hendrik, Knebel Doeberitz, Magnus, Sampson, Julian R., Vasen, Hans, Mecklin, Jukka‐Pekka, Møller, Pål, Kloor, Matthias

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Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer von Elomaa, Hanna, Ahtiainen, Maarit, Väyrynen, Sara A., Ogino, Shuji, Nowak, Jonathan A., Friman, Marjukka, Helminen, Olli, Wirta, Erkki-Ville, Seppälä, Toni T., Böhm, Jan, Mäkinen, Markus J., Mecklin, Jukka-Pekka, Kuopio, Teijo, Väyrynen, Juha P.

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Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome von Engel, Christoph, Ahadova, Aysel, Seppälä, Toni T., Aretz, Stefan, Bigirwamungu-Bargeman, Marloes, Bläker, Hendrik, Bucksch, Karolin, Büttner, Reinhard, de Vos tot Nederveen Cappel, Wouter T., Endris, Volker, Holinski-Feder, Elke, Holzapfel, Stefanie, Hüneburg, Robert, Jacobs, Maarten A.J.M., Koornstra, Jan J., Langers, Alexandra M., Lepistö, Anna, Morak, Monika, Möslein, Gabriela, Peltomäki, Päivi, Pylvänäinen, Kirsi, Rahner, Nils, Renkonen-Sinisalo, Laura, Schulmann, Karsten, Steinke-Lange, Verena, Stenzinger, Albrecht, Strassburg, Christian P., van de Meeberg, Paul C., van Kouwen, Mariette, van Leerdam, Monique, Vangala, Deepak B., Vecht, Juda, Verhulst, Marie-Louise, von Knebel Doeberitz, Magnus, Weitz, Jürgen, Zachariae, Silke, Loeffler, Markus, Mecklin, Jukka-Pekka, Kloor, Matthias, Vasen, Hans F.

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The Different Immune Profiles of Normal Colonic Mucosa in Cancer-Free Lynch Syndrome Carriers and Lynch Syndrome Colorectal Cancer Patients von Bohaumilitzky, Lena, Kluck, Klaus, Hüneburg, Robert, Gallon, Richard, Nattermann, Jacob, Kirchner, Martina, Kristiansen, Glen, Hommerding, Oliver, Pfuderer, Pauline L., Wagner, Lelia, Echterdiek, Fabian, Kösegi, Svenja, Müller, Nico, Fischer, Konstantin, Nelius, Nina, Hartog, Ben, Borthwick, Gillian, Busch, Elena, Haag, Georg Martin, Bläker, Hendrik, Möslein, Gabriela, von Knebel Doeberitz, Magnus, Seppälä, Toni T., Ahtiainen, Maarit, Mecklin, Jukka-Pekka, Bishop, D. Timothy, Burn, John, Stenzinger, Albrecht, Budczies, Jan, Kloor, Matthias, Ahadova, Aysel

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Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines von Cavestro, Giulia Martina, Mannucci, Alessandro, Balaguer, Francesc, Hampel, Heather, Kupfer, Sonia S., Repici, Alessandro, Sartore-Bianchi, Andrea, Seppälä, Toni T., Valentini, Vincenzo, Boland, Clement Richard, Brand, Randall E., Buffart, Tineke E., Burke, Carol A., Caccialanza, Riccardo, Cannizzaro, Renato, Cascinu, Stefano, Cercek, Andrea, Crosbie, Emma J., Danese, Silvio, Dekker, Evelien, Daca-Alvarez, Maria, Deni, Francesco, Dominguez-Valentin, Mev, Eng, Cathy, Goel, Ajay, Guillem, Josè G., Houwen, Britt B.S.L., Kahi, Charles, Kalady, Matthew F., Kastrinos, Fay, Kühn, Florian, Laghi, Luigi, Latchford, Andrew, Liska, David, Lynch, Patrick, Malesci, Alberto, Mauri, Gianluca, Meldolesi, Elisa, Møller, Pål, Monahan, Kevin J., Möslein, Gabriela, Murphy, Caitlin C., Nass, Karlijn, Ng, Kimmie, Oliani, Cristina, Papaleo, Enrico, Patel, Swati G., Puzzono, Marta, Remo, Andrea, Ricciardiello, Luigi, Ripamonti, Carla Ida, Siena, Salvatore, Singh, Satish K., Stadler, Zsofia K., Stanich, Peter P., Syngal, Sapna, Turi, Stefano, Urso, Emanuele Damiano, Valle, Laura, Vanni, Valeria Stella, Vilar, Eduardo, Vitellaro, Marco, You, Yi-Qian Nancy, Yurgelun, Matthew B., Zuppardo, Raffaella Alessia, Stoffel, Elena M.

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Towards evidence-based personalised precision medicine for Lynch syndrome von Møller, Pål, Sampson, Julian R, Dominguez-Valentin, Mev, Seppälä, Toni T

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Systemic circulating microRNA landscape in Lynch syndrome von Sievänen, Tero, Korhonen, Tia-Marje, Jokela, Tiina, Ahtiainen, Maarit, Lahtinen, Laura, Kuopio, Teijo, Lepistö, Anna, Sillanpää, Elina, Mecklin, Jukka-Pekka, Seppälä, Toni T, Laakkonen, Eija K

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Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer von Elomaa, Hanna, Härkönen, Jouni, Väyrynen, Sara A., Ahtiainen, Maarit, Ogino, Shuji, Nowak, Jonathan A., Lau, Mai Chan, Helminen, Olli, Wirta, Erkki-Ville, Seppälä, Toni T., Böhm, Jan, Mecklin, Jukka-Pekka, Kuopio, Teijo, Väyrynen, Juha P.

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Prospective observational data informs understanding and future management of Lynch syndrome: insights from the Prospective Lynch Syndrome Database (PLSD) von Seppälä, Toni T., Dominguez-Valentin, Mev, Sampson, Julian R., Møller, Pål

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Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations von Seppälä, Toni T, Pylvänäinen, Kirsi, Mecklin, Jukka-Pekka

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High immune cell infiltration predicts improved survival in cholangiocarcinoma von Wirta, Erkki-Ville, Szeto, Säde, Koppatz, Hanna, Nordin, Arno, Mäkisalo, Heikki, Arola, Johanna, Sirén, Jukka, Ahtiainen, Maarit, Böhm, Jan, Mecklin, Jukka-Pekka, Sallinen, Ville, Seppälä, Toni T

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