Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity von Collier, Jenna L., Weiss, Sarah A., Pauken, Kristen E., Sen, Debattama R., Sharpe, Arlene H.

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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade von Miller, Brian C., Sen, Debattama R., Al Abosy, Rose, Bi, Kevin, Virkud, Yamini V., LaFleur, Martin W., Yates, Kathleen B., Lako, Ana, Felt, Kristen, Naik, Girish S., Manos, Michael, Gjini, Evisa, Kuchroo, Juhi R., Ishizuka, Jeffrey J., Collier, Jenna L., Griffin, Gabriel K., Maleri, Seth, Comstock, Dawn E., Weiss, Sarah A., Brown, Flavian D., Panda, Arpit, Zimmer, Margaret D., Manguso, Robert T., Hodi, F. Stephen, Rodig, Scott J., Sharpe, Arlene H., Haining, W. Nicholas

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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade von Pauken, Kristen E., Sammons, Morgan A., Odorizzi, Pamela M., Manne, Sasikanth, Godec, Jernej, Khan, Omar, Drake, Adam M., Chen, Zeyu, Sen, Debattama R., Kurachi, Makoto, Barnitz, R. Anthony, Bartman, Caroline, Bengsch, Bertram, Huang, Alexander C., Schenkel, Jason M., Vahedi, Golnaz, Haining, W. Nicholas, Berger, Shelley L., Wherry, E. John

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The epigenetic landscape of T cell exhaustion von Sen, Debattama R., Kaminski, James, Barnitz, R. Anthony, Kurachi, Makoto, Gerdemann, Ulrike, Yates, Kathleen B., Tsao, Hsiao-Wei, Godec, Jernej, LaFleur, Martin W., Brown, Flavian D., Tonnerre, Pierre, Chung, Raymond T., Tully, Damien C., Allen, Todd M., Frahm, Nicole, Lauer, Georg M., Wherry, E. John, Yosef, Nir, Haining, W. Nicholas

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Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade von Ishizuka, Jeffrey J., Manguso, Robert T., Cheruiyot, Collins K., Bi, Kevin, Panda, Arpit, Iracheta-Vellve, Arvin, Miller, Brian C., Du, Peter P., Yates, Kathleen B., Dubrot, Juan, Buchumenski, Ilana, Comstock, Dawn E., Brown, Flavian D., Ayer, Austin, Kohnle, Ian C., Pope, Hans W., Zimmer, Margaret D., Sen, Debattama R., Lane-Reticker, Sarah K., Robitschek, Emily J., Griffin, Gabriel K., Collins, Natalie B., Long, Adrienne H., Doench, John G., Kozono, David, Levanon, Erez Y., Haining, W. Nicholas

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PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity von LaFleur, Martin W., Nguyen, Thao H., Coxe, Matthew A., Miller, Brian C., Yates, Kathleen B., Gillis, Jacob E., Sen, Debattama R., Gaudiano, Emily F., Al Abosy, Rose, Freeman, Gordon J., Haining, W. Nicholas, Sharpe, Arlene H.

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Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans von Yates, Kathleen B., Tonnerre, Pierre, Martin, Genevieve E., Gerdemann, Ulrike, Al Abosy, Rose, Comstock, Dawn E., Weiss, Sarah A., Wolski, David, Tully, Damien C., Chung, Raymond T., Allen, Todd M., Kim, Arthur Y., Fidler, Sarah, Fox, Julie, Frater, John, Lauer, Georg M., Haining, W. Nicholas, Sen, Debattama R.

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Suppression by T FR cells leads to durable and selective inhibition of B cell effector function von Sage, Peter T, Ron-Harel, Noga, Juneja, Vikram R, Sen, Debattama R, Maleri, Seth, Sungnak, Waradon, Kuchroo, Vijay K, Haining, W Nicholas, Chevrier, Nicolas, Haigis, Marcia, Sharpe, Arlene H

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Migratory DCs activate TGF-β to precondition naïve CD8 + T cells for tissue-resident memory fate von Mani, Vinidhra, Bromley, Shannon K, Äijö, Tarmo, Mora-Buch, Rut, Carrizosa, Esteban, Warner, Ross D, Hamze, Moustafa, Sen, Debattama R, Chasse, Alexandra Y, Lorant, Alina, Griffith, Jason W, Rahimi, Rod A, McEntee, Craig P, Jeffrey, Kate L, Marangoni, Francesco, Travis, Mark A, Lacy-Hulbert, Adam, Luster, Andrew D, Mempel, Thorsten R

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Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states von Podestà, Manuel A., Cavazzoni, Cecilia B., Hanson, Benjamin L., Bechu, Elsa D., Ralli, Garyfallia, Clement, Rachel L., Zhang, Hengcheng, Chandrakar, Pragya, Lee, Jeong-Mi, Reyes-Robles, Tamara, Abdi, Reza, Diallo, Alos, Sen, Debattama R., Sage, Peter T.

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Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory von Tonnerre, Pierre, Wolski, David, Subudhi, Sonu, Aljabban, Jihad, Hoogeveen, Ruben C., Damasio, Marcos, Drescher, Hannah K., Bartsch, Lea M., Tully, Damien C., Sen, Debattama R., Bean, David J., Brown, Joelle, Torres-Cornejo, Almudena, Robidoux, Maxwell, Kvistad, Daniel, Alatrakchi, Nadia, Cui, Ang, Lieb, David, Cheney, James A., Gustafson, Jenna, Lewis-Ximenez, Lia L., Massenet-Regad, Lucile, Eisenhaure, Thomas, Aneja, Jasneet, Haining, W. Nicholas, Chung, Raymond T., Hacohen, Nir, Allen, Todd M., Kim, Arthur Y., Lauer, Georg M.

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A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade von Chen, Ivy X., Newcomer, Kathleen, Pauken, Kristen E., Juneja, Vikram R., Naxerova, Kamila, Wu, Michelle W., Pinter, Matthias, Sen, Debattama R., Singer, Meromit, Sharpe, Arlene H., Jain, Rakesh K.

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The aged tumor microenvironment limits T cell control of cancer von Chen, Alex C. Y., Jaiswal, Sneha, Martinez, Daniela, Yerinde, Cansu, Ji, Keely, Miranda, Velita, Fung, Megan E., Weiss, Sarah A., Zschummel, Maria, Taguchi, Kazuhiro, Garris, Christopher S., Mempel, Thorsten R., Hacohen, Nir, Sen, Debattama R.

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Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling von Brown, Flavian D., Sen, Debattama R., LaFleur, Martin W., Godec, Jernej, Lukacs-Kornek, Veronika, Schildberg, Frank A., Kim, Hye-Jung, Yates, Kathleen B., Ricoult, Stéphane J. H., Bi, Kevin, Trombley, Justin D., Kapoor, Varun N., Stanley, Illana A., Cremasco, Viviana, Danial, Nika N., Manning, Brendan D., Sharpe, Arlene H., Haining, W. Nicholas, Turley, Shannon J.

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Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses von Cañadas, Israel, Thummalapalli, Rohit, Kim, Jong Wook, Kitajima, Shunsuke, Jenkins, Russell William, Christensen, Camilla Laulund, Campisi, Marco, Kuang, Yanan, Zhang, Yanxi, Gjini, Evisa, Zhang, Gao, Tian, Tian, Sen, Debattama Rai, Miao, Diana, Imamura, Yu, Thai, Tran, Piel, Brandon, Terai, Hideki, Aref, Amir Reza, Hagan, Timothy, Koyama, Shohei, Watanabe, Masayuki, Baba, Hideo, Adeni, Anika Elise, Lydon, Christine Anne, Tamayo, Pablo, Wei, Zhi, Herlyn, Meenhard, Barbie, Thanh Uyen, Uppaluri, Ravindra, Sholl, Lynnette Marie, Sicinska, Ewa, Sands, Jacob, Rodig, Scott, Wong, Kwok Kin, Paweletz, Cloud Peter, Watanabe, Hideo, Barbie, David Allen

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Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy von Martin, Genevieve E., Sen, Debattama R., Pace, Matthew, Robinson, Nicola, Meyerowitz, Jodi, Adland, Emily, Thornhill, John P., Jones, Mathew, Ogbe, Ane, Parolini, Lucia, Olejniczak, Natalia, Zacharopoulou, Panagiota, Brown, Helen, Willberg, Christian B., Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Haining, W. Nicholas, Frater, John

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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control von Weiss, Sarah A., Huang, Amy Y., Fung, Megan E., Martinez, Daniela, Chen, Alex C. Y., LaSalle, Thomas J., Miller, Brian C., Scharer, Christopher D., Hegde, Mudra, Nguyen, Thao H., Rowe, Jared H., Osborn, Jossef F., Patterson, Dillon G., Sifnugel, Natalia, Mei-An Nolan, C., Davidson, Richard A., Schwartz, Marc A., Bally, Alexander P. R., Neeld, Dennis K., LaFleur, Martin W., Boss, Jeremy M., Doench, John G., Nicholas Haining, W., Sharpe, Arlene H., Sen, Debattama R.

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Abstract 654: The epigenetic landscape of T cell exhaustion von Sen, Debattama

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Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade von Fox, Douglas B., Ebright, Richard Y., Hong, Xin, Russell, Hunter C., Guo, Hongshan, LaSalle, Thomas J., Wittner, Ben S., Poux, Nicolas, Vuille, Joanna A., Toner, Mehmet, Hacohen, Nir, Boland, Genevieve M., Sen, Debattama R., Sullivan, Ryan J., Maheswaran, Shyamala, Haber, Daniel A.

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Author Correction: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade von Miller, Brian C., Sen, Debattama R., Al Abosy, Rose, Bi, Kevin, Virkud, Yamini V., LaFleur, Martin W., Yates, Kathleen B., Lako, Ana, Felt, Kristen, Naik, Girish S., Manos, Michael, Gjini, Evisa, Kuchroo, Juhi R., Ishizuka, Jeffrey J., Collier, Jenna L., Griffin, Gabriel K., Maleri, Seth, Comstock, Dawn E., Weiss, Sarah A., Brown, Flavian D., Panda, Arpit, Zimmer, Margaret D., Manguso, Robert T., Hodi, F. Stephen, Rodig, Scott J., Sharpe, Arlene H., Haining, W. Nicholas

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